Zero--Temperature Quantum Phase Transition of a Two--Dimensional Ising Spin--Glass

We study the quantum transition at $T=0$ in the spin-$\frac12$ Ising spin--glass in a transverse field in two dimensions. The world line path integral representation of this model corresponds to an effective classical system in (2+1) dimensions, which we study by Monte Carlo simulations. Values of the critical exponents are estimated by a finite-size scaling analysis. We find that the dynamical exponent, $z$, and the correlation length exponent, $\nu$, are given by $z = 1.5 \pm 0.05$ and $\nu = 1.0 \pm 0.1$. Both the linear and non-linear susceptibility are found to diverge at the critical point.Comment: RevTeX 10 pages + 4 figures (appended as uuencoded, compressed tar-file), THP21-9

Random bond Ising chain in a transverse magnetic field: A finite-size scaling analysis

We investigate the zero-temperature quantum phase transition of the random bond Ising chain in a transverse magnetic field. Its critical properties are identical to those of the McCoy-Wu model, which is a classical Ising model in two dimensions with layered disorder. The latter is studied via Monte Carlo simulations and transfer matrix calculations and the critical exponents are determined with a finite-size scaling analysis. The magnetization and susceptibility obey conventional rather than activated scaling. We observe that the order parameter-- and correlation function--probability distribution show a nontrivial scaling near the critical point which implies a hierarchy of critical exponents associated with the critical behavior of the generalized correlation lengths.Comment: RevTeX 13 pages + 4 figures (appended as uuencoded compressed tar-file), THP61-9

Common trends in the critical behavior of the Ising and directed walk models

We consider layered two-dimensional Ising and directed walk models and show that the two problems are inherently related. The information about the zero-field thermodynamical properties of the Ising model is contained into the transfer matrix of the directed walk. For several hierarchical and aperiodic distributions of the couplings, critical exponents for the two problems are obtained exactly through renormalization.Comment: 4 pages, RevTeX file + 1 figure, epsf needed. To be published in PR

Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial

Peer reviewe

Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression

Glycyrrhizin is known to exert antiviral and anti-inflammatory effects. Here, the effects of an approved parenteral glycyrrhizin preparation (Stronger Neo-Minophafen C) were investigated on highly pathogenic influenza A H5N1 virus replication, H5N1-induced apoptosis, and H5N1-induced pro-inflammatory responses in lung epithelial (A549) cells. Therapeutic glycyrrhizin concentrations substantially inhibited H5N1-induced expression of the pro-inflammatory molecules CXCL10, interleukin 6, CCL2, and CCL5 (effective glycyrrhizin concentrations 25 to 50 µg/ml) but interfered with H5N1 replication and H5N1-induced apoptosis to a lesser extent (effective glycyrrhizin concentrations 100 µg/ml or higher). Glycyrrhizin also diminished monocyte migration towards supernatants of H5N1-infected A549 cells. The mechanism by which glycyrrhizin interferes with H5N1 replication and H5N1-induced pro-inflammatory gene expression includes inhibition of H5N1-induced formation of reactive oxygen species and (in turn) reduced activation of NFκB, JNK, and p38, redox-sensitive signalling events known to be relevant for influenza A virus replication. Therefore, glycyrrhizin may complement the arsenal of potential drugs for the treatment of H5N1 disease

Investigating generation mechanisms of tyre/road noise by speed exponent analysis

The purpose of this study is to clarify the influence of air-pumping related noise sources on typical tyre/road noise. The aim is to increase the understanding of noise generation mechanisms and catalyse the development of existing tyre/road noise simulation tools. The speed dependency of measured and simulated tyre/road noise is analysed and the results show that a large part of the noise can be explained by a high speed exponent traditionally connected with air-pumping mechanisms. Surprisingly, this is also the case for rough road surfaces which are expected to mainly generate noise by tyre vibrations. It is also found that vehicle wind noise may have a strong influence on the pass-by noise and care must be taken when analysing measurement data of quiet tyre/road combinations. Even simulated tyre/road noise shows higher speed exponents than what is anticipated without the inclusion of any type of air-pumping mechanism in the model. It is concluded that it is unfeasible to separate noise created by tyre vibrations from noise created by air-pumping with a speed exponent analysis due to the overlap in the speed exponents connected with the different generation mechanisms

Influence of the tyre impedance on CPX level used to evaluate tyre/road noise

For traffic noise studies CPX measurements are used to evaluate the noise-reduction of a road surface.CPX measurements as described in ISO/DIS 11819-2 are carried out at microphone positions close to predefined tyres at constant speed. The dominant CPX sound source is the tyre’s rolling noise as a result of tyre/road interaction, which - apart from the acoustic properties of the road surface - is mainly determined by the properties of the tyre.To ensure continuous quality and comparability of CPX measurements, the variation of acoustically relevant properties of the reference tyres must be taken into account to reduce measurement uncertainties. Thus, to ensure comparability, the standard ISO/TS 11819-3 specifies Shore hardness values to be checked at regular intervals and compared with normative values. According to our experience in CPX-measurements, determining the Shore hardness of the tyres is not sufficient to describe the reference tyres’ acoustically relevant properties. So, as an additional parameter the mechanical impedance of different reference tyres was measured and compared to their Shore hardness and CPX levels on different road surfaces.Based on these results, conclusions are drawn about the usability of the tyre impedance to increase the quality and comparability of CPX measurements