A note on symmetry reductions of the Lindblad equation: transport in constrained open spin chains

We study quantum transport properties of an open Heisenberg XXZ spin 1/2 chain driven by a pair of Lindblad jump operators satisfying a global `microcanonical' constraint, i.e. conserving the total magnetization. We will show that this system has an additional discrete symmetry which is particular to the Liouvillean description of the problem. Such symmetry reduces the dynamics even more than what would be expected in the standard Hilbert space formalism and establishes existence of multiple steady states. Interestingly, numerical simulations of the XXZ model suggest that a pair of distinct non-equilibrium steady states becomes indistinguishable in the thermodynamic limit, and exhibit sub-diffusive spin transport in the easy-axis regime of anisotropy Delta > 1.Comment: 14 pages with 5 pdf figures, revised version, as accepted by New Journal of Physic

Morphological Characters of the Thickbody Skate Amblyraja frerichsi (Krefft 1968) (Rajiformes: Rajidae), with Notes on Its Biology

Detailed descriptions of morphological features, morphometrics, neurocranium anatomy, clasper structure and egg case descriptions are provided for the thickbody skate Amblyraja frerichsi; a rare, deep-water species from Chile, Argentina and Falkland Islands. The species diagnosis is complemented from new observations and aspects such as colour, size and distribution are described. Geographic and bathymetric distributional ranges are discussed as relevant features of this taxońs biology. Additionally, the conservation status is assessed including bycatch records from Chilean fisheries

Syntaxin binding mechanism and disease-causing mutations in Munc18-2

Mutations in either syntaxin 11 (Stx11) or Munc18-2 abolish cytotoxic T lymphocytes (CTL) and natural killer cell (NK) cytotoxicity, and give rise to familial hemophagocytic lymphohistiocytosis (FHL4 or FHL5, respectively). Although Munc18-2 is known to interact with Stx11, little is known about the molecular mechanisms governing the specificity of this interaction or how in vitro IL-2 activation leads to compensation of CTL and NK cytotoxicity. To understand how mutations in Munc18-2 give rise to disease, we have solved the structure of human Munc18-2 at 2.6 angstrom resolution and mapped 18 point mutations. The four surface mutations identified (R39P, L130S, E132A, P334L) map exclusively to the predicted syntaxin and soluble N-ethylmaleimide-sensitive factor accessory protein receptor binding sites of Munc18-2. We find that Munc18-2 binds the N-terminal peptide of Stx11 with a similar to 20-fold higher affinity than Stx3, suggesting a potential role in selective binding. Upon IL-2 activation, levels of Stx3 are increased, favoring Munc18-2 binding when Stx11 is absent. Similarly, Munc18-1, expressed in IL-2-activated CTL, is capable of binding Stx11. These findings provide potential explanations for restoration of Munc18-Stx function and cytotoxicity in IL-2-activated cells

From sustainable community to Big Society: ten years learning with the Imagine approach

Community is a key word in the current UK political vocabulary. As part of Big Society or as a sustainable means to develop social coherence, community has been an area of focus which has attained UK political party interest since 2003. In 1999 the Imagine method was first hinted at in the Earthscan book: ‘Sustainability Indicators: measuring the immeasurable’. The approach allows citizens to learn about and self-evaluate their own sustainability by developing their own sustainability indicators in a manner which is participatory and evidence-based. Communities could make use of the approach, not in an attempt to arrive at some ‘absolute’ value of sustainability, but in striving to achieve a self-knowing sense of how sustainable they are, by their own measured indicators and to use this evaluation in discourse with other agencies such as local and national government. The tone of Imagine is to empower citizens to own their own sustainability and to plan for sustainable futures. The method, developed for spatial and temporal sustainability assessment, has been trialled by countries in the Mediterranean region within Coastal Area Management Programmes (CAMPs). Building off this engagement with geographically and culturally diverse communities, the method has been supported by the Homes and Communities Agency (HCA) in the UK and developed into a teaching module which has been subsequently tested at undergraduate, postgraduate, continuing professional development (CPD), Virtual Learning Environment (VLE) and working with practitioners, as a hands-on Masterclass . The resulting course: Creating Sustainable Communities (CSC) has now been introduced to 20 UK Universities and has seen use by 7. This paper tracks the development of the Imagine method, explores its major elements and sets out the learning impacts it has had to-date

FCHO controls AP2's initiating role in endocytosis through a Ptdlns(4,5)P-2-dependent switch

Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 requires membrane-localized Fer/Cip4 homology domain-only proteins (FCHO). Here, live-cell enhanced total internal reflection fluorescence-structured illumination microscopy shows that FCHO marks sites of clathrin-coated pit (CCP) initiation, which mature into uniform-sized CCPs comprising a central patch of AP2 and clathrin corralled by an FCHO/Epidermal growth factor potential receptor substrate number 15 (Eps15) ring. We dissect the network of interactions between the FCHO interdomain linker and AP2, which concentrates, orients, tethers, and partially destabilizes closed AP2 at the plasma membrane. AP2's subsequent membrane deposition drives its opening, which triggers FCHO displacement through steric competition with phosphatidylinositol 4,5-bisphosphate, clathrin, cargo, and CME accessory factors. FCHO can now relocate toward a CCP's outer edge to engage and activate further AP2s to drive CCP growth/maturation

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

The cytosolic appearance and propagation of bacteria cause overwhelming cellular stress responses that induce apoptosis under normal conditions. Therefore, successful bacterial colonization depends on the ability of intracellular pathogens to block apoptosis and to safeguard bacterial replicative niches. Here, we show that the cytosolic Gram-negative bacterium Shigella flexneri stalls apoptosis by inhibiting effector caspase activity. Our data identified lipopolysaccharide (LPS) as a bona fide effector caspase inhibitor that directly binds caspases by involving its O-antigen (O Ag) moiety. Bacterial strains that lacked the O Ag or failed to replicate within the cytosol were incapable of blocking apoptosis and exhibited reduced virulence in a murine model of bacterial infection. Our findings demonstrate how Shigella inhibits pro-apoptotic caspase activity, effectively delays coordinated host-cell demise and supports its intracellular propagation. Next to the recently discovered pro-inflammatory role of cytosolic LPS, our data reveal a distinct mode of LPS action that, through the disruption of the early coordinated non-lytic cell death response, ultimately supports the inflammatory breakdown of infected cells at later time points. The lipopolysaccharide of the intracellular pathogen Shigella, in particular its O antigen, interacts with caspases and blocks their activation to prevent apoptosis