37 research outputs found
Soft Tissue Sarcoma: The Predominant Primary Malignancy in the Retroperitoneum
Purpose. In the clinical work-up of a retroperitoneal mass, the diagnosis of soft tissue sarcoma is often not considered. Incidence
rates of various malignant and benign retroperitoneal tumours were studied to determine the incidence of soft tissue
sarcoma in comparison with other neoplasms in the retroperitoneal space
Supine MRI for regional breast radiotherapy: Imaging axillary lymph nodes before and after sentinel-node biopsy
Regional radiotherapy (RT) is increasingly used in breast cancer treatment.
Conventionally, computed tomography (CT) is performed for RT planning.
Lymph node (LN) target levels are delineated according to anatomical
boundaries. Magnetic resonance imaging (MRI) could enable individual LN
delineation. The purpose was to evaluate the applicability of MRI for LN
detection in supine treatment position, before and after sentinel-node biopsy
(SNB). Twenty-three female breast cancer patients (cTis-3N0M0) underwent
1.5 T MRI, before and after SNB, in addition to CT. Endurance for MRI was
monitored. Axillary levels were delineated. LNs were identified and delineated
on MRI from before and after SNB, and on CT, and compared by Wilcoxon
signed-rank tests. LN locations and LN-based volumes were related to axillary
delineations and associated volumes. Although postoperative effects were
visible, LN numbers on postoperative MRI (median 26 LNs) were highly
reproducible compared to preoperative MRI when adding excised sentinel
nodes, and higher than on CT (median 11, p < 0.001). LN-based volumes
were considerably smaller than respective axillary levels. Supine MRI of LNs
is feasible and reproducible before and after SNB. This may lead to more
accurate RT target definition compared to CT, with potentially lower toxicity.
With the MRI techniques described here, initiation of novel MRI-guided RT
strategies aiming at individual LNs could be possible
Dynamics of Flux Creep in Underdoped Single Crystals of Y_1-xPr_xBa_2Cu_3O_7-d
Transport as well as magnetic relaxation properties of the mixed state were
studied on strongly underdoped Y_1-xPr_xBa_2Cu_3O_7-d crystals. We observed two
correlated phenomena - a coupling transition and a transition to quantum creep.
The distribution of transport current below the coupling transition is highly
nonuniform, which facilitates quantum creep. We speculate that in the mixed
state below the coupling transition, where dissipation is nonohmic, the current
distribution may be unstable with respect to self-channeling resulting in the
formation of very thin current-carrying layers.Comment: 11 pages, 9 figures, Submitted to Phys. Rev.
FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0
The aim of this guideline is to provide a minimum standard for the acquisition and interpretation of PET and PET/CT scans with [18F]-fluorodeoxyglucose (FDG). This guideline will therefore address general information about [18F]-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) and is provided to help the physician and physicist to assist to carrying out, interpret, and document quantitative FDG PET/CT examinations, but will concentrate on the optimisation of diagnostic quality and quantitative information
Impact of [(18)F]FDG PET imaging parameters on automatic tumour delineation: need for improved tumour delineation methodology
Het loopt niet zo’n vaart – Een economische beschouwing over Nieuwe Economie, versnelling en onthaasting
Locoregional recurrence of retroperitoneal soft tissue sarcoma:second chance of cure for selected patients
Background: Locoregional recurrence of a retroperitoneal soft tissue sarcoma (RSTS) may offer a second chance of curative surgical treatment. In a population-based study the proportion of patients developing isolated locoregional recurrences (LR) was determined and the outcome of these patients was analysed. Method: In a retrospective nationwide study, data were collected on 142 patients treated between I January 1989 and I January 1994 for primary RSTS. In patients who had been treated radically for their primary sarcoma (77/142, 54%), the pattern of recurrence was evaluated. Factors predictive of survival for patients with LR were studied. Results: After a median follow-up of 86 (range 60-101) months, 32 patients (42%) had developed LR, and distant metastasis (DM) had been diagnosed in 17 patients (22%). Median disease-free interval between the initial operation and the establishment of LR or DM was 22 and 19 months, respectively. Five-year cumulative survival of patients with established LR was 37% in comparison with 11% for patients with DM (P=0.062). Factors predictive of favourable outcome in patients with LR were the absence of multifocal recurrence (n = 13; P = 0.01), lipomatous histomorphology (n = 20; P = 0.02), and a complete resection of recurrent sarcoma (n = 17; P = 0.04). Conclusion: After a median follow-up of 7 years following radical treatment of a primary RSTS, 42% of the patients had developed isolated locoregional recurrences. A complete resection of recurrent disease, lipomatous histomorphology and the absence of multifocal growth influenced prognosis favourably. (C) 2001 Harcourt Publishers Ltd