Nitrite reduction in paracoccus halodenitrificans: Evidence for the role of a cd-type cytochrome in ammonia formation

Cell-free extracts prepared from Paracoccus halodenitrificans catalyzed the reduction of nitrate to ammonia in the presence of dithionite and methyl viologen. Enzyme activity was located in the soluble fraction and was associated with a cytochrome whose spectral properties resembled those of a cd-type cytochrome. Unlike the sissimilatory cd-cytochrome nitrate reductase associated with the membrane fraction of P. halodenitrificans, this soluble cd-cytochrome did not reduce nitrite to nitrous oxide

Evaluation of a Conversation Management Toolkit for Multi Agent Programming

The Agent Conversation Reasoning Engine (ACRE) is intended to aid agent developers to improve the management and reliability of agent communication. To evaluate its effectiveness, a problem scenario was created that could be used to compare code written with and without the use of ACRE by groups of test subjects. This paper describes the requirements that the evaluation scenario was intended to meet and how these motivated the design of the problem. Two experiments were conducted with two separate sets of students and their solutions were analysed using a combination of simple objective metrics and subjective analysis. The analysis suggested that ACRE by default prevents some common problems arising that would limit the reliability and extensibility of conversation-handling code. As ACRE has to date been integrated only with the Agent Factory multi agent framework, it was necessary to verify that the problems identified are not unique to that platform. Thus a comparison was made with best practice communication code written for the Jason platform, in order to demonstrate the wider applicability of a system such as ACRE.Comment: appears as Programming Multi-Agent Systems - 10th International Workshop, ProMAS 2012, Valencia, Spain, June 5, 2012, Revised Selected Paper

Clinical Efficacy of TroVax in the Treatment of Progressive Castration-resistant Prostate Cancer

With approximately 240,890 new cases expected in 2011, prostate cancer remains the leading cause of non-melanoma cancer deaths in men. Immunotherapies using viral vector-based delivery systems targeting tumor-specific antigens are being studied. Viral vector-based delivery systems present tumor-targeted antigens (TAAs) to the immune system while breaking self-tolerance. Modified vaccinia ankara has been combined with the oncofetal antigen 5T4 to create TroVax for the treatment of castration-resistant prostate cancer (CRPC). The 5T4 antigen is highly expressed in a large number of carcinomas, including prostate cancer, but is rarely expressed in healthy tissue. TroVax has been demonstrated to be safe and highly immunogenic, both as monotherapy and in combination with other standard of care therapies in colorectal, renal cell, and prostate cancer. With minimal side effects and the ability to produce a strong immunogenic response, TroVax (MVA-5T4) is a viable addition to the treatment of prostate cancer

TOSCA-based orchestration of complex clusters at the IaaS level

[EN] This paper describes the adoption and extension of the TOSCA standard by the INDIGO-DataCloud project for the definition and deployment of complex computing clusters together with the required support in both OpenStack and OpenNebula, carried out in close collaboration with industry partners such as IBM. Two examples of these clusters are described in this paper, the definition of an elastic computing cluster to support the Galaxy bioinformatics application where the nodes are dynamically added and removed from the cluster to adapt to the workload, and the definition of an scalable Apache Mesos cluster for the execution of batch jobs and support for long-running services. The coupling of TOSCA with Ansible Roles to perform automated installation has resulted in the definition of high-level, deterministic templates to provision complex computing clusters across different Cloud sites.The authors would like to thank the European Commission for the financial support for project INDIGO-DataCloud (RIA 653549)Caballer Fernández, M.; Donvito, G.; Moltó, G.; Rocha, R.; Velten, M. (2017). TOSCA-based orchestration of complex clusters at the IaaS level. Journal of Physics: Conference Series (Online). 898:1-8. https://doi.org/10.1088/1742-6596/898/8/082036S1889

Parallel, Adaptive Grid Computing of Multiphase Flows in Spacecraft Fuel Tanks

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97138/1/AIAA2012-761.pd