An autopsy study of a fouled reverse osmosis membrane element used in a brackish water treatment plant

The fouling of a spiral wound reverse osmosis (RO) membrane after nearly 1 year of service in a brackish water treatment plant was investigated using optical and electron microscopic methods, Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma atomic emission spectrometry (ICP-AES). Both the top surface and the cross-section of the fouled membrane were analysed to monitor the development of the fouling layer. It has been found that the extent of fouling was uneven across the membrane surface with regions underneath or in the vicinity of the strands of the feed spacer being more severely affected. Fouling appeared to have developed through different stages. In particular, it consisted of an initial thin fouling layer of an amorphous matrix with embedded particulate matter. The amorphous matrix comprised organic–Al–P complexes and the particulate matter was mostly aluminium silicates. Subsequently, as the fouling layer reached a thickness of about 5–7 μm, further amorphous material, which is suggested to include extracellular polymeric substances such as polysaccharides, started to deposit on top of the existing fouling layer. This secondary amorphous material did not seem to contain any particulate matter nor any inorganic elements within it, but acted as a substrate upon which aluminium silicate crystals grew exclusively in the absence of other foulants, including natural organic matter (NOM

Separation of aqueous salt solution by pervaporation through hybrid organic-inorganic membrane: effect of operating conditions

Hybrid polymer-inorganic membranes were prepared by crosslinking poly(vinyl alcohol) (PVA), maleic acid (MA) and silica via an aqueous sol–gel route. Membrane characterisation results revealed silica nanoparticles (b10 nm) were well dispersed in the polymer matrix and significantly reduced swelling of the membrane. The membranes were tested for pervaporation separation of aqueous salt solution with NaCl concentrations of 0.2–5.0 wt% at temperatures 20–65 °C, feed flowrates 30–150 mL/min and permeate pressures 2–40 Torr. The salt rejection remained high (up to 99.9%) under all operating conditions. A high water flux of 11.7 kg/m2 h could be achieved at a feed temperature of 65 °C and a vacuum of 6 Torr. The effect of operating conditions on water flux is discussed in relation to diffusion coefficients of water and fundamental transport mechanism through the membrane. The activation energy for water permeation was found to vary from 23.8 to 20.1 kJ/kmol when the salt concentration in the feed was increased from 0.2 to 5.0 wt%

Piloted simulation study of a balloon-assisted deployment of an aircraft at high altitude

A piloted simulation was used to study the feasibility of a balloon assisted deployment of a research aircraft at high altitude. In the simulation study, an unmanned, modified sailplane was carried to 110,000 ft with a high altitude balloon and released in a nose down attitude. A remote pilot controlled the aircraft through a pullout and then executed a zoom climb to a trimmed, 1 g flight condition. A small parachute was used to limit the Mach number during the pullout to avoid adverse transonic effects. The use of small rocket motor was studied for increasing the maximum attainable altitude. Aerodynamic modifications to the basic sailplane included applying supercritical airfoil gloves over the existing wing and tail surfaces. The aerodynamic model of the simulated aircraft was based on low Reynolds number wind tunnel tests and computational techniques, and included large Mach number and Reynolds number effects at high altitude. Parametric variations were performed to study the effects of launch altitude, gross weight, Mach number limit, and parachute size on the maximum attainable stabilized altitude. A test altitude of approx. 95,000 ft was attained, and altitudes in excess of 100,000 ft was attained

Precision constraints on radiative neutrino decay with CMB spectral distortion

We investigate the radiative decay of the cosmic neutrino background, and its impact on the spectrum of the cosmic microwave background (CMB) that is known to be a nearly perfect black body. We derive exact formulae for the decay of a heavier neutrino into a lighter neutrino and a photon, $\nu_j \to \nu_i + \gamma$, and of absorption as its inverse, $\nu_i + \gamma \to \nu_j$, by accounting for the precise form of the neutrino momentum distribution. Our calculations show that if the neutrinos are heavier than $\mathcal O(0.1)$ eV, the exact formulae give results that differ by $\sim$50%, compared with approximate ones where neutrinos are assumed to be at rest. We also find that spectral distortion due to absorption is more important for heavy neutrino masses (by a factor of $\sim$10 going from a neutrino mass of 0.01 eV to 0.1 eV). By analyzing the CMB spectral data measured with COBE-FIRAS, we obtain lower limits on the neutrino lifetime of $\tau_{12} \gtrsim 4 \times 10^{21}$ s (95% C.L.) for the smaller mass splitting and $\tau_{13} \sim \tau_{23} \gtrsim 10^{19}$ s for the larger mass splitting. These represent up to one order of magnitude improvement over previous CMB constraints. With future CMB experiments such as PIXIE, these limits will improve by roughly 4 orders of magnitude. This translates to a projected upper limit on the neutrino magnetic moment (for certain neutrino masses and decay modes) of $\mu_\nu < 3 \times 10^{-11}\, \mu_B$, where $\mu_B$ is the Bohr magneton. Such constraints would make future precision CMB measurements competitive with lab-based constraints on neutrino magnetic moments.Comment: 14 pages, 9 figures. v2: Added a number of references and clarifications. Matches version published in PR

Biphasic pattern in the effect of severe measles infection; the difference between additive and multiplicative scale.

BACKGROUND: Infection with measles virus (MeV) causes immunosuppression and increased susceptibility to other infectious diseases. Only few studies reported a duration of immunosuppression, with varying results. We investigated the effect of immunosuppression on the incidence of hospital admissions for infectious diseases in Vietnamese children. METHODS: We used retrospective data (2005 to 2015; N = 4419) from the two pediatric hospitals in Ho Chi Minh City, Vietnam. We compared the age-specific incidence of hospital admission for infectious diseases before and after hospitalization for measles. We fitted a Poisson regression model that included gender, current age, and time since measles to obtain a multiplicative effect measure. Estimates were transformed to the additive scale. RESULTS: We observed two phases in the incidence of hospital admission after measles. The first phase started with a fourfold increased rate of admissions during the first month after measles, dropping to a level quite comparable to children of the same age before measles. In the second phase, lasting until at least 6 years after measles, the admission rate decreased further, with values up to 20 times lower than in children of the same age before measles. However, on the additive scale the effect size in the second phase was much smaller than in the first phase. CONCLUSION: The first phase highlights the public health benefits of measles vaccination by preventing measles and immune amnesia. The beneficial second phase is interesting, but its strength strongly depends on the scale. It suggests a complicated interaction between MeV infection and the host immunity

The Metabolic Syndrome Is Associated With Lower Cognitive Performance and Reduced White Matter Integrity in Midlife: The CARDIA Study

BackgroundCardiovascular disease risk factors play a critical role in brain aging. The metabolic syndrome (MetS), a constellation of cardiovascular risk factors, has been associated with poorer cognition in old age; however, it is unclear if it is connected to brain health earlier in life.MethodsWe investigated the association of MetS (n = 534, 18.5%) vs. no MetS (n = 2,346, 81.5%) with cognition in midlife within the prospective study, Coronary Artery Risk Development in Young Adults (CARDIA). At midlife (mean age 50), MetS was defined using National Cholesterol Education Program guidelines. At the 5-year follow-up, a cognitive battery was administered including tests of processing speed (Digit Symbol Substitution Test, DSST), executive function (the Stroop Test), verbal memory (Rey Auditory Verbal Learning Test, RAVLT), verbal fluency (category and letter fluency), and global cognitive function (Montreal Cognitive Assessment, MoCA). A sub-sample (n = 453) underwent brain MRI.ResultsParticipants with MetS had worse performance on tests of verbal fluency, processing speed, executive function, and verbal memory (p &lt; 0.05), but not on global cognition. MetS was also associated with lower frontal, parietal, temporal, and total white matter integrity (p &lt; 0.05), as assessed with fractional anisotropy.ConclusionsMetS is associated with lower cognition and microstructural brain alterations already at midlife, suggesting that MetS should be targeted earlier in life in order to prevent adverse brain and cognitive outcomes

Thermal management of an interventional medical device with double layer encapsulation

This paper presents a thermal study of a double-layer encapsulation for an interventional medical device, which operates temporarily inside the human esophagus for cardiac imaging. The surface temperature of test samples, representing the device, was assessed by experiments and numerical simulations. The test samples consisted of a heat source, a heat sink and a double-layer encapsulation consisting of a 3D printed biocompatible polymer (thickness 0.9 mm), with an electroplated Cu inner layer (0, 10, 80 or 150 µm thick). The surface temperature of test samples was measured in a tissue-mimicking thermal phantom at 37°C, with different heat source power levels. Experimental results showed that the maximum steady-state surface temperature could be reduced significantly by a 10 µm thick Cu layer (compared to no Cu layer). Increasing the Cu layer thickness further had a rather small effect, at least for low power levels. The maximum steady-state surface temperature was an exponential function of the Cu layer thickness. Test samples with a Cu electroplated polymer encapsulation and a heat source power of 0.5 W satisfied the maximum temperature limit for thermal safety (43°C) when the Cu layer was thicker than about 80 µm. Simulated surface temperatures were in good agreement with experimental values, for a model using two different thermal contact conductance coefficients (for different materials) for the sample-phantom boundary condition. The simulation model was also used to suggest alternative materials for the outer layer of an encapsulation with a metal inner layer, for reducing the surface temperature.publishedVersio

Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam.

BACKGROUND: typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. Typhoid fever is caused by the bacterial pathogen Salmonella enterica serovar Typhi (S. Typhi), which is frequently multidrug resistant with reduced susceptibility to fluoroquinolone-based drugs, the first choice for the treatment of typhoid fever. We used a GoldenGate (Illumina) assay to type 1,500 single nucleotide polymorphisms (SNPs) and analyse the genetic variation of S. Typhi isolated from 267 typhoid fever patients in the Mekong delta region participating in a randomized trial conducted between 2004 and 2005. PRINCIPAL FINDINGS: the population of S. Typhi circulating during the study was highly clonal, with 91% of isolates belonging to a single clonal complex of the S. Typhi H58 haplogroup. The patterns of disease were consistent with the presence of an endemic haplotype H58-C and a localised outbreak of S. Typhi haplotype H58-E2 in 2004. H58-E2-associated typhoid fever cases exhibited evidence of significant geo-spatial clustering along the Sông H u branch of the Mekong River. Multidrug resistance was common in the established clone H58-C but not in the outbreak clone H58-E2, however all H58 S. Typhi were nalidixic acid resistant and carried a Ser83Phe amino acid substitution in the gyrA gene. SIGNIFICANCE: the H58 haplogroup dominates S. Typhi populations in other endemic areas, but the population described here was more homogeneous than previously examined populations, and the dominant clonal complex (H58-C, -E1, -E2) observed in this study has not been detected outside Vietnam. IncHI1 plasmid-bearing S. Typhi H58-C was endemic during the study period whilst H58-E2, which rarely carried the plasmid, was only transient, suggesting a selective advantage for the plasmid. These data add insight into the outbreak dynamics and local molecular epidemiology of S. Typhi in southern Vietnam