On variability and reliability of poly-Si thin-film transistors

In contrast to conventional bulk-silicon technology, polysilicon (poly-Si) thin-film transistors (TFTs) can be implanted in flexible substrate and can have low process temperature. These attributes make poly-Si TFT technology more attractive for new applications, such as flexible displays, biosensors, and smart clothing. However, due to the random nature of grain boundaries (GBs) in poly-Si film and self-heating enhanced negative bias temperature instability (NBTI), the variability and reliability of poly-Si TFTs are the main obstacles that impede the application of poly-Si TFTs in high-performance circuits. The primary focus of this dissertation is to develop new design methodologies and modeling techniques for facilitating new applications of poly-Si TFT technology. In order to do that, a physical model is first presented to characterize the GB-induced transistor threshold voltage (V th)variations considering not only the number but also the position and orientation of each GB in 3-D space. The fast computation time of the proposed model makes it suitable for evaluation of GB-induced transistor Vthvariation in the early design phase. Furthermore, a self-consistent electro-thermal model that considers the effects of device geometry, substrate material, and stress conditions on NBTI is proposed. With the proposed modeling methodology, the significant impacts of device geometry, substrate, and supply voltage on NBTI in poly-Si TFTs are shown. From a circuit design perspective, a voltage programming pixel circuit is developed for active-matrix organic light emitting diode (AMOLED) displays for compensating the shift of Vth and mobility in driver TFTs as well as compensating the supply voltage degradation. In addition, a self-repair design methodology is proposed to compensate the GB-induced variations for liquid crystal displays (LCDs) and AMOLED displays. Based on the simulation results, the proposed circuit can decrease the required supply voltage by 20% without performance and yield degradation. In the final section of this dissertation, an optimization methodology for circuit-level reliability tests is explored. To effectively predict circuit lifetime, accelerated aging (i.e. elevated voltage and temperature) is commonly applied in circuit-level reliability tests, such as constant voltage stress (CVS) and ramp voltage stress (RVS) tests. However, due to the accelerated aging, shifting of dominant degradation mechanism might occur leading to the wrong lifetime prediction. To get around this issue, we proposed a technique to determine the proper stress range for accelerated aging tests

A compound power-law model for volcanic eruptions: Implications for risk assessment of volcanism at the proposed nuclear waste repository at Yucca Mountain, Nevada

Much of the ongoing debate on the use of nuclear power plants in U.S.A. centers on the safe disposal of the radioactive waste. Congress, aware of the importance of the waste issue, passed the Nuclear Waste Policy Act of 1982, requiring the federal government to develop a geologic repository for the permanent disposal of high level radioactive wastes from civilian nuclear power plants. The Department of Energy (DOE) established the Office of Civilian Radioactive Waste Management (OCRWM) in 1983 to identify potential sites. When OCRWM had selected three potential sites to study, Congress enacted the Nuclear Waste Policy Amendments Act of 1987, which directed the DOE to characterize only one of those sites, Yucca Mountain, in southern Nevada. For a site to be acceptable, theses studies must demonstrate that the site could comply with regulations and guidelines established by the federal agencies that will be responsible for licensing, regulating, and managing the waste facility. Advocates and critics disagree on the significance and interpretation of critical geological features which bear on the safety and suitability of Yucca Mountain as a site for the construction of a high-level radioactive waste repository. Recent volcanism in the vicinity of Yucca Mountain is readily recognized as an important factor in determining future public and environmental safety because of the possibility of direct disruption of a repository site by volcanism. In particular, basaltic volcanism is regarded as direct and unequivocal evidence of deep-seated geologic instability. In this paper, statistical analysis of volcanic hazard assessment at the Yucca Mountain site is discussed, taking into account some significant geological factors raised by experts. Three types of models are considered in the data analysis. The first model assumes that both past and future volcanic activities follow a homogeneous Poisson process (HPP)

One-Sided Group Sequential Procedures for Clinical Trials

1 online resource (PDF, 17 pages

Addiction and Substance Abuse among Nevada Youths

Adolescence is a critical stage for substance abuse initiation, as well as for substance abuse prevention, intervention, and treatment. This report presents tobacco product use, alcohol use, and illicit drug use rates of Nevada’s youths (aged 12-17) compared with youths nationwide as a whole. Most data were retrieved from the Substance Abuse and Mental Health Services Administration (SAMHSA), including the 2008--2009 National Survey on Drug Use and Health (NSDUH) data and Treatment Episode Data Set (TEDS), supplemented with the Centers for Disease Control and Prevention (CDC)’s 2009 Youth Risk Behavior Survey (YRBS) data. Substate data were taken from SAMHSA’s 2006-2008 NSDUH data, the most updated substate data available so far. The 2010 NSDUH state-level data won’t be released by SAMHSA until 2012

All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation

All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells. It has been indicated that cyclin-dependent kinase 5 (Cdk5) activity can be affected by ATRA treatment. Our previous results demonstrate the involvement of Cdk5 in the fate of prostate cancer cells. The purpose of this study is to examine whether Cdk5 is involved in ATRA-induced growth arrest of the castration-resistant cancer cell line DU145 through up-regulating Cdk inhibitor protein, p27