The Hidden Side of Transparency among Government Agency Bloggers

This paper shows and discusses blogs as social action in a corporate context by investigating and seeking to understand organizational bloggers’ motivations and discursive behaviors in the contextual and cultural diversity of a\ud blog-setting. Providing empirical findings on the possibilities and limitations that are embedded in an organizational blog in a government agency context, traced\ud through focus group interviews of the organizational bloggers, the paper shows that culturally bound limitations exist and are exposed when implementing an open-source social technology like the weblog. People, even within the same organization, have different goals in relation to the same technology, and the transparency of the blog and the blog comments is managed differently by the internal bloggers. Through the discussion of the different cultural discourses at work in the blog, diverging roles and dilemmas that the blogging employees meet when engaging in corporate blogging are exposed and discussed. The aim of the paper is to discuss the social implications of these different cultural discourses in a corporate blog and how corporate cultural tensions emerge because of the blog. The paper pinpoints the problematic of transparency through pointing out conflicting goals, roles and the resulting self-censorship by bloggers as they operate in an environment that is increasingly transparent, and shows examples of\ud how the group of bloggers with the shared narrative tradition is able to mobilize its members and create subgroups for appropriate blog behaviors and changing\ud behavior due to self-censorship, as well as identification with the key actors in the group

The Enterprise Social Media Relations Strategy: The Case of Maersk Line

The purpose of this article is to show and discuss how corporate social media usage is driven by people, not technology, and how the creation of a culture of participation on the part of a company, in this case the world’s largest container shipping company with 25,000 employees worldwide, Maersk Line (www.maerskline.com), requires a systematic, user-driven listen-and-learn strategy with a clear selection of purpose and social platform according to audience and topics. This effort needs to be continuously dedicated and aligned, focusing on which relationships the company wants to form

Fra Vitskøl Kloster til herregården Bjørnsholm, 1536-1590

Vitskøl Kloster var et stort munkekloster af cisterciensernes orden. Det blev stiftet i 1158 af kong Valdemar den Store, som af sin fædrene arv skænkede landsbyen Vitskøl med alt tilliggende til opførelse af abbediet. Rejsningen af det centrale klosteranlæg, en stor klosterkirke og dertil tre fløje, blev påbegyndt ved 1200-tallets indgang og først afsluttet i det tidlige 1500-tal. Det fortsatte formelt som kloster efter Reformationen, men blev sekulariseret i 1563, hvor det blev et len, inden det i 1573 overgik til privat besiddelse. Vitskøl Kloster var blevet til herregården Bjørnsholm. Under en stor restaurering af Vitskøl Kloster (1982- 1996) blev der indsamlet væsentlige iagttagelser om både det middelalderlige kloster og de eftermiddelalderlige ændringer. Det arkæologiske materiale er suppleret med et stort skriftligt kildemateriale, hvilket giver mulighed for en rimelig detaljeret bygningshistorisk redegørelse ved transformationen fra et kloster til en herregård, der skete gennem nedrivning og ombygning af klosterfløje samt nybygning. Til udredning af de økonomiske forhold i denne overgangstid umiddelbart efter Reformationen præsenteres en transskription af mageskiftet mellem kongen og adelsmanden Bjørn Andersen i 1573. Mageskiftet sammenholdes med abbed Anders’ jordebog fra 1552, og der redegøres for klosterets sammensatte økonomi, der i hvert fald delvis må have forudsætninger i den senmiddelalderlige godsdrift

Induced pluripotent stem cells (iPSCs) derived from af pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia

AbstractSkin fibroblasts were obtained from a 28-year-old pre-symptomatic woman carrying a R406W mutation in microtubule-associated protein tau (MAPT), known to cause frontotemporal dementia. Induced pluripotent stem cell (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.1216C>T substitution in exon 13 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT)

AbstractSkin fibroblasts were obtained from a 57-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a P301L mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.902C>T substitution in exon 10 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT)

AbstractSkin fibroblasts were obtained from a 59-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a R406W mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.1216C>T substitution in exon 13 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro

Combining Literature Review With a Ground Truth Approach for Diagnosing Huntington's Disease Phenocopy.

One percent of patients with a Huntington's disease (HD) phenotype do not have the Huntington (HTT) gene mutation. These are known as HD phenocopies. Their diagnosis is still a challenge. Our objective is to provide a diagnostic approach to HD phenocopies based on medical expertise and a review of the literature. We employed two complementary approaches sequentially: a review of the literature and two surveys analyzing the daily clinical practice of physicians who are experts in movement disorders. The review of the literature was conducted from 1993 to 2020, by extracting articles about chorea or HD-like disorders from the database Pubmed, yielding 51 articles, and analyzing 20 articles in depth to establish the surveys. Twenty-eight physicians responded to the first survey exploring the red flags suggestive of specific disease entities. Thirty-three physicians completed the second survey which asked for the classification of paraclinical tests according to their diagnostic significance. The analysis of the results of the second survey used four different clustering algorithms and the density-based clustering algorithm DBSCAN to classify the paraclinical tests into 1st, 2nd, and 3rd-line recommendations. In addition, we included suggestions from members of the European Reference Network-Rare Neurological Diseases (ERN-RND Chorea & Huntington disease group). Finally, we propose guidance that integrate the detection of clinical red flags with a classification of paraclinical testing options to improve the diagnosis of HD phenocopies

Corrigendum: Combining Literature Review With a Ground Truth Approach for Diagnosing Huntington's Disease Phenocopy.

[This corrects the article DOI: 10.3389/fneur.2022.817753.]

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in <em>PSEN-1</em>

AbstractInduced pluripotent stem cells (iPSCs) were generated from skin fibroblasts isolated from a 58-year old male with a L150P mutation in the presenilin 1 (PSEN-1) gene, which is responsible for the majority of familial cases of Alzheimer's disease (AD). The iPSCs were established by co-electroporation with episomal plasmids containing hOCT4, hSOX2, hL-MYC, hKLF4, hNANOG, hLIN28, and short hairpin RNA against TP53. The iPSCs contained the specific heterozygous mutation c.449C>T, had normal karyotype, expressed the expected pluripotency genes and displayed in vitro differentiation potential to the three germ layers. The iPSCs may be useful for studying familial AD pathology in vitro