Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. A large proportion of associations comprised missense variants, half of which lie within known familial hearing loss loci. We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and basal cells from the stria vascularis, a structure in the cochlea necessary for normal hearing. Our findings indicate the importance of the stria vascularis in the mechanism of hearing impairment, providing future paths for developing targets for therapeutic intervention in hearing loss

On Stability of C*-algebras

Let A be a oe-unital C -algebra, i.e. A admits a countable approximate unit. It is proved that A is stable, i.e. A is isomorphic to A\Omega K where K is the algebra of compact operators on a separable Hilbert space, if and only if for each positive element a 2 A and each " ? 0 there exists a positive element b 2 A such that kabk ! " and x x = a, xx = b for some x in A. Using this characterization it is proved among other things that the inductive limit of any sequence of oe-unital stable C -algebras is stable, and that the crossed product of a oe-unital stable C -algebra by a discrete group is again stable. 1 Introduction One can characterize stable AF-algebras as being precisely those AF-algebras that do not admit a bounded densely defined trace. This can be seen by using the classification of AF-algebras by their ordered K 0 -group (see also Section 5). One motivation for this paper is if a similar strong characterization of stable C -algebras might hold in g..

On Stability of C*-algebras

Let A be a oe-unital C*-algebra, i.e. A admits a countable approximate unit. It is proved that A is stable, i.e. A is isomorphic to A\Omega K where K is the algebra of compact operators on a separable Hilbert space, if and only if for each positive element a 2 A and each " ? 0 there exists a positive element b 2 A such that kabk ! " and x x = a, xx = b for some x in A. Using this characterization it is proved among other things that the inductive limit of any sequence of oe-unital stable C -algebras is stable, and that the crossed product of a oe-unital stable C -algebra by a discrete group is again stable

Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort

Genet Med advance online publication 23 March 2017Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR).C.R.C. has received funding from Vetenskapsrådet, Lars Hiertas Minne, Magnus Bergvalls Stiftelserna, Tysta Skolan, and Karolinska Institutet. B.C. has received funding from the Swedish Medical Council, Tysta Skolan, and Karolinska Institutet. The work was supported by an independent research program funded under the Biomedicine and Molecular Biosciences European Cooperation in Science and Technology (COST) Action framework (TINNET, BM1306).Ye

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. A large proportion of associations comprised missense variants, half of which lie within known familial hearing loss loci. We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and basal cells from the stria vascularis, a structure in the cochlea necessary for normal hearing. Our findings indicate the importance of the stria vascularis in the mechanism of hearing impairment, providing future paths for developing targets for therapeutic intervention in hearing loss.publishedVersionPeer reviewe