Myocarditis Diagnosed in Twins

Background: Myocarditis is inflammation of the cardiac myocytes. In the first 6 months of life, myocarditis is slow-progressing and sudden death is common. It should not be forgotten that these patients can have intrauterine myocarditis. Case Presentation: A 4-month-old male patient had fast breathing and cyanosis during crying in the last month. At admission, we found tachypnea and hypoxia in his physical examination, and cardiomegaly on the chest radiogram. Subsequently, dilatation of left ventricle and left atrium, systolic dysfunction of left ventricle, and mitral valve regurgitation were found in echocardiography. The patient was diagnosed with myocarditis. We were informed that he had a twin brother, so we evaluated the second baby too. Similar but less severe findings were obtained in the echocardiographic examination of the twin brother, who had normal findings in physical examination. Infectious and metabolic scanning tests were performed on both patients. The underlying cause could not be spotted. Sizes of ventricles and atria, and left ventricle functions of the patients were found to be normal with treatment at the end of the 6th week. Conclusion: Four-month-old twins were diagnosed and recovered from myocarditis with supportive therapy in a short time. We think that the twins had intrauterine myocarditis

Giant Right Atrial Aneurysm Accompanying Intrahepatic Cholestasis

Right atrial aneurysms were first described in 1955, and subsequently, only a few cases have been reported. The etiology of this condition is unknown. Its comorbidity with cholestasis has not previously been reported in the literature. An 11-month-old baby female, who was an offspring from a first-cousin marriage, was referred to our hospital for investigation of jaundice. She underwent echocardiography because of a heart murmur, and this revealed a giant right atrial aneurysm. In addition, her liver biopsy confirmed the diagnosis of progressive familial intrahepatic cholestasis (PFIC) type 3. Although both conditions are rare, we found their comorbidity interesting and are thus reporting the case

Subclinical hypothyroidism in obese Turkish adolescents: the relationship with anthropometry and fatty liver

Aim: To evaluate whether subclinical hypothyroidism (SH) is associated with anthropometry and fatty infiltration of liver in obese adolescents

Relation of fetuin A levels with cardiac, subcutaneous lipid accumulation and insulin resistance parameters in Turkish obese children

Background: Fetuin A is an inhibitor of insulin action and have been found to be related with subcutaneous lipid accumulation and insulin resistance. The relation of cardiac lipid accumulation, fetuin A and insulin resistance parameters in obese children is not well-known. The aim of the study was to evaluate the relation of serum fetuin A levels with subcutaneous and cardiac lipid accumulation, and insulin resistance parameters in Turkish obese children

Echocardiographic Measurement of Epicardial Adipose Tissue in Obese Children

The echocardiographic measurement of epicardial adipose tissue (EAT) has been suggested as an easy method for evaluation of the visceral adipose tissue and its related cardiovascular risks in adults. However, a direct effect of obesity on cardiac function is not well established, and echocardiographic EAT thickness has not been studied in children. The aims of this study were to evaluate cardiac function and echocardiographic EAT thickness and to correlate EAT with the other echocardiographic findings in obese children. The study population included 106 obese and 62 lean children. Echocardiographic indexes of systolic and diastolic function were obtained. We measured EAT thickness on the free wall of the right ventricle from parasternal long-axis views. The septal and posterior wall thicknesses, relative wall thickness, left atrial diameter, and left ventricular mass were increased (p = 0.001) in obese children. However, systolic and diastolic functions of the left ventricle were normal in the patients. The obese children had a significantly thicker EAT (p = 0.001) compared to the lean subjects. EAT thickness correlated significantly with body mass index (r = 0.50, p = 0.001), left atrial diameter (r = 0.37, p = 0.001), and left ventricular mass (r = 0.33, p = 0.001). In conclusion, the present study demonstrates a close relationship between EAT thickness and obesity in children. Assessment of EAT thickness in routine echocardiographic examinations might be used as a feasible and reliable method for the evaluation of obesity and its related cardiovascular risks during childhood

Relation of subepicardial adipose tissue thickness and clinical and metabolic parameters in obese prepubertal children

Background: The measurement of subepicardial adipose tissue thickness (SATT) has been found to be related to insulin resistance (IR) in adults. Until now, the association between SATT and IR has not been evaluated in obese prepubertal children. We aimed to determine the relation of SATT with clinical anthropometric and metabolic parameters and to provide cutoff value of SATT associated with IR in obese prepubertal children

Chorzy trudni nietypowiWspółistnienie zespołu Eisenmengera i młodzieńczego zapalenia stawów - opis przypadku

An 8.5-year-old girl evaluated for central cyanosis, hypoxia and normocarbia was found to have aorticopulmonary window and pulmonary hypertension. The diagnosis of Eisenmenger syndrome (ES) was made and treatment with bosentan was started. Four months later she was diagnosed to have juvenile rheumatoid arthritis and naproxen treatment was started. The case was remarkable in that she showed clinical improvement with new generation treatment of ES although pulmonary arterial pressure did not decrease significantly and the diagnosis of juvenile rheumatoid arthritis was made during follow-up

Serebral kalsifikasyon tanısı alan hastalar çölyak hastalığı açısındanaraştırılmalı mı?

Amaç: Bu çalışmada Çölyak hastalığı ve serebral kalsifikasyon arasındaki ilişki ve prevalansı saptamayı amaçladık.Gereç ve Yöntemler: Serebral kalsifikasyonu olan çocuklar çölyak hastalığı yönünden anti-doku transglutaminaz IgA kullanılarak tarandı.Bulgular: Toplamda 129 serebral kalsifikasyonu olan hasta (6 ay-16 yaş arası 75 erkek ve 54 kız) tetkik edildi. Kontrol grubu 223 sağlıklı çocuktan oluşmaktaydı. Çölyak hastalığı olan hastalarda serebral kalsifikasyon anlamlı olarak yüksek bulundu (p0.01). Üç hastanın duodenal biyopsisinde total villus atrofisi saptandı. Bu hastalarda demir eksikliği anemisi ve boy kısalığı mevcuttu. Bu hastalarda oksipital lobda kalsifikasyon saptanmadı. Koroid pleksus ve pineal glandda nonspesifik kalsifikasyonlar saptandı.Sonuç: Çalışmamızın sonuçlarına göre, intrakranial kalsifikasyonun çölyak hastalarında az miktarda olması intrakranial kalsifikasyon ve çölyak hastalığı arasında güçlü bir birliktelik olmadığını gösterdi. Pineal gland ve koroid pleksusta kalsifikasyonun olması Çölyak hastalığı ile ilişkili olabilir.Objective: In this study, we aimed to examine the prevalence and relationship of celiac disease (CD) in children with cerebral calcifications (CC). Material and Methods: Children with cerebral calcifications were screened for celiac disease using the anti-tissue transglutaminase IgA antibody. Results: A total of 129 children with CC (75 boys, 54 girls; age: 6 months to 16 years) were evaluated. Control group consisted of 223 healthy children. The prevalence of CD was significantly higher in patients with CC than control subjects (p0.01). In three patients pathological examination of duodenal biopsy resulted as total villous atrophy. All three patients had both iron deficiency anemia and short stature problem. Although, no calcification in occipital lobe was detected in computed tomography of these three patients, there were nonspecific calcifications in choroid plexus and pineal gland localizations. Conclusion: According to results from our study, prevalence of celiac disease being low in patients with intracerebral calcifications suggested that there is not a strong correlation between development of calcification and celiac disease. It suggested that occurrence of calcification in choroid plexus and/or pineal gland might be related to celiac disease