Strategic targeting: the effect of institutions and interests on distributive transfers

Virtually every government provides distributive transfers for electoral purposes. However, the level and form of such transfers vary dramatically across countries. Although transfers take many forms, they can generally be characterized as being either broad (providing benefits to large segments of the electorate) or narrow (targeting benefits only to select groups of voters). Variation in the form of distributive transfers across countries can be explained by voters' economic interests and domestic institutions. Voters' preferences over transfer form, shaped in part by the mobility of their assets, together with a country's electoral rules determine the benefits politicians gain from providing either broad or narrow transfers. Using new measures of transfer form, the author finds that although majoritarian systems are more prone to narrow transfers, proportional systems are more responsive to increases in voter demand for narrow transfers, all else equal

TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection

10.1038/s41598-020-60761-5Scientific Reports101381

Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens

Clostridium perfringens is a Gram-positive, anaerobic spore-forming bacterium commonly found in soil, sediments, and the human gastrointestinal tract. C. perfringens is responsible for a wide spectrum of disease, including food poisoning, gas gangrene (clostridial myonecrosis), enteritis necroticans, and non-foodborne gastrointestinal infections. The complete genome sequences of Clostridium perfringens strain ATCC 13124, a gas gangrene isolate and the species type strain, and the enterotoxin-producing food poisoning strain SM101, were determined and compared with the published C. perfringens strain 13 genome. Comparison of the three genomes revealed considerable genomic diversity with >300 unique “genomic islands” identified, with the majority of these islands unusually clustered on one replichore. PCR-based analysis indicated that the large genomic islands are widely variable across a large collection of C. perfringens strains. These islands encode genes that correlate to differences in virulence and phenotypic characteristics of these strains. Significant differences between the strains include numerous novel mobile elements and genes encoding metabolic capabilities, strain-specific extracellular polysaccharide capsule, sporulation factors, toxins, and other secreted enzymes, providing substantial insight into this medically important bacterial pathogen