Copper(II)- and gold(III)-mediated cyclization of a thiourea to a substituted 2-aminobenzothiazole

Benzothiazole derivatives are a class of privileged molecules due to their biological activity and pharmaceutical applications. One route to these molecules is via intramolecular cyclization of thioureas to form substituted 2-aminobenzothiazoles, but this often requires harsh conditions or employs expensive metal catalysts. Herein, the copper(II)- and gold(III)-mediated cyclizations of thioureas to substituted 2-aminobenzothiazoles are reported. The single-crystal X-ray structures of the thiourea N-(3-methoxyphenyl)-N\u27- (pyridin-2-yl)thiourea, C13H13N3OS, and the intermediate metal complexes aquabis[5-methoxy-N-(pyridin-2-yl-κN)-1,3-benzothiazol-2-amine-κN3]copper(II) dinitrate, [Cu(C13H11N3OS)2(H2O)](NO3)2, and bis{2-[(5-methoxy-1,3-benzothiazol- 2-yl)amino]pyridin-1-ium} dichloridogold(I) chloride monohydrate, (C13H12N3OS)2[AuCl2]Cl⋅H2O, are reported. The copper complex exhibits a distorted trigonal–bipyramidal geometry, with direct metal-to-benzothiazoleligand coordination, while the gold complex is a salt containing the protonated uncoordinated benzothiazole, and offers evidence that metal reduction (in this case, AuIII to AuI) is required for the cyclization to proceed. As such, this study provides further mechanistic insight into the role of the metal cations in these transformations

Astrophysical Bounds on Global Strings

Global topological defects produce nonzero stress-energy throughout spacetime, and as a result can have observable gravitational influence on surrounding matter. Gravitational effects of global strings are used to place bounds on their cosmic abundance. The minimum separation between global strings is estimated by considering the defects' contribution to the cosmological energy density. More rigorous constraints on the abundance of global strings are constructed by examining the tidal forces such defects will have on observable astrophysical systems. The small number of observed tidally disrupted systems indicates there can be very few of these objects in the observable universe.Comment: 14 pages, REVTe

Baryon inhomogeneity generation via cosmic strings at QCD scale and its effects on nucleosynthesis

We have earlier shown that cosmic strings moving through the plasma at the time of a first order quark-hadron transition in the early universe can generate large scale baryon inhomogeneities. In this paper, we calculate detailed structure of these inhomogeneities at the quark-hadron transition. Our calculations show that the inhomogeneities generated by cosmic string wakes can strongly affect nucleosynthesis calculations. A comparison with observational data suggests that such baryon inhomogeneities should not have existed at the nucleosynthesis epoch. If this disagreement holds with more accurate observations, then it will lead to the conclusions that cosmic string formation scales above $10^{14} - 10^{15}$ GeV may not be consistent with nucleosynthesis and CMBR observations. Alternatively, some other input in our calculation should be constrained, for example, if the average string velocity remains sufficiently small so that significant density perturbations are never produced at the QCD scale, or if strings move ultra-relativistically so that string wakes are very thin, trapping negligible amount of baryons. Finally, if quark-hadron transition is not of first order then our calculations do not apply.Comment: 24 pages, 5 figures, minor changes, version to appear in Phys. Rev.

Renormalization Group Approach to Causal Viscous Cosmological Models

The renormalization group method is applied to the study of homogeneous and flat Friedmann-Robertson-Walker type Universes, filled with a causal bulk viscous cosmological fluid. The starting point of the study is the consideration of the scaling properties of the gravitational field equations, of the causal evolution equation of the bulk viscous pressure and of the equations of state. The requirement of scale invariance imposes strong constraints on the temporal evolution of the bulk viscosity coefficient, temperature and relaxation time, thus leading to the possibility of obtaining the bulk viscosity coefficient-energy density dependence. For a cosmological model with bulk viscosity coefficient proportional to the Hubble parameter, we perform the analysis of the renormalization group flow around the scale invariant fixed point, therefore obtaining the long time behavior of the scale factor.Comment: 19 pages. RevTeX4. Revised version. Accepted in Classical and Quantum Gravit

Cosmic string induced sheet like baryon inhomogeneities at quark-hadron transition

Cosmic strings moving through matter produce wakes where density is higher than the background density. We investigate the effects of such wakes occurring at the time of a first order quark-hadron transition in the early universe and show that they can lead to separation of quark-gluon plasma phase in the wake region, while the region outside the wake converts to the hadronic phase. Moving interfaces then trap large baryon densities in sheet like regions which can extend across the entire horizon. Typical separation between such sheets, at formation, is of the order of a km. Regions of baryon inhomogeneity of this nature, i.e. having a planar geometry, and separated by such large distance scales, appear to be well suited for the recent models of inhomogeneous nucleosynthesis to reconcile with the large baryon to photon ratio implied by the recent measurements of the cosmic microwave background power spectrum.Comment: 8 pages, 3 figure

Viscous Bianchi type I universes in brane cosmology

We consider the dynamics of a viscous cosmological fluid in the generalized Randall-Sundrum model for an anisotropic, Bianchi type I brane. To describe the dissipative effects we use the Israel-Hiscock-Stewart full causal thermodynamic theory. By assuming that the matter on the brane obeys a linear barotropic equation of state, and the bulk viscous pressure has a power law dependence on the energy density, the general solution of the field equations can be obtained in an exact parametric form. The obtained solutions describe generally a non-inflationary brane world. In the large time limit the brane Universe isotropizes, ending in an isotropic and homogeneous state. The evolution of the temperature and of the comoving entropy of the Universe is also considered, and it is shown that due to the viscous dissipative processes a large amount of entropy is created in the early stages of evolution of the brane world.Comment: 13 pages, 5 figures, to appear in Class. Quantum Gra

The perilous state of seagrass in the British Isles

Seagrass ecosystems face widespread threat from reduced water quality, coastal development and poor land use. In recent decades, their distribution has declined rapidly, and in the British Isles, this loss is thought to have been extensive. Given increasing knowledge of how these ecosystems support fisheries production, the understanding of their potential rapid loss, and the difficulty in restoring them, it is vital we develop an understanding of the risks they are under, so that management actions can be developed accordingly. Developing an understanding of their environmental status and condition is therefore critical to their long-term management. This study provided, to our knowledge, the first examination of the environmental health of seagrass meadows around the British Isles. This study used a bioindicator approach and involved collecting data on seagrass density and morphology alongside analysis of leaf biochemistry. Our study provides, to the best of our knowledge, the first strong quantitative evidence that seagrass meadows of the British Isles are mostly in poor condition in comparison with global averages, with tissue nitrogen levels 75% higher than global values. Such poor status places their long-term resilience in doubt. Elemental nutrient concentrations and morphological change suggest conditions of excess nitrogen and probable low light, placing many of the meadows sampled in a perilous state, although others, situated away from human populations were perceived to be healthy. Although some sites were of a high environmental health, all sites were considered at risk from anthropogenic impacts, particularly poor water quality and boating-based disturbances. The findings of this study provide a warning of the need to take action, with respect to water quality and disturbance, to prevent the further loss and degradation of these systems across the British Isles

High-frequency monitoring of nitrogen and phosphorus response in three rural catchments to the end of the 2011–2012 drought in England

This paper uses high-frequency bankside measurements from three catchments selected as part of the UK government-funded Demonstration Test Catchments (DTC) project. We compare the hydrological and hydrochemical patterns during the water year 2011–2012 from the Wylye tributary of the River Avon with mixed land use, the Blackwater tributary of the River Wensum with arable land use and the Newby Beck tributary of the River Eden with grassland land use. The beginning of the hydrological year was unusually dry and all three catchments were in states of drought. A sudden change to a wet summer occurred in April 2012 when a heavy rainfall event affected all three catchments. The year-long time series and the individual storm responses captured by in situ nutrient measurements of nitrate and phosphorus (total phosphorus and total reactive phosphorus) concentrations at each site reveal different pollutant sources and pathways operating in each catchment. Large storm-induced nutrient transfers of nitrogen and or phosphorus to each stream were recorded at all three sites during the late April rainfall event. Hysteresis loops suggested transport-limited delivery of nitrate in the Blackwater and of total phosphorus in the Wylye and Newby Beck, which was thought to be exacerbated by the dry antecedent conditions prior to the storm. The high rate of nutrient transport in each system highlights the scale of the challenges faced by environmental managers when designing mitigation measures to reduce the flux of nutrients to rivers from diffuse agricultural sources. It also highlights the scale of the challenge in adapting to future extreme weather events under a changing climate

Bianchi Type I Universes with Causal Bulk Viscous Cosmological Fluid

We consider the dynamics of a causal bulk viscous cosmological fluid filled constantly decelerating Bianchi type I space-time. The matter component of the Universe is assumed to satisfy a linear barotropic equation of state and the state equation of the small temperature Boltzmann gas. The resulting cosmological models satisfy the condition of smallness of the viscous stress. The time evolution of the relaxation time, temperature, bulk viscosity coefficient and comoving entropy of the dissipative fluid is also obtained.Comment: 11 pages, 5 figures, accepted for publication in International Journal of Modern Physics