An Interesting Case of Type A Wolff-Parkinson-White Syndrome

A case of Wolff-Parkinson-White syndrome who presented with a tachycardia showing an unusual QRS morphology closely resembling that of a ventricular tachycardia was reported. It showed type A or type B conduction of the Wolff-Parkinson-White syndrome in electrocardiogram in different time, but vectorcardiogram showed always type A conduction. After combinated administration of Quinidine and Reserpine, ECG reversed constantly to normal sinus rhythm

Effect of Methotrexate Plus Adalimumab on the Achievement of Rheumatoid Arthritis Therapeutic Goals : Post Hoc Analysis of Japanese Patients (MELODY Study)

Introduction: There is insufficient evidence regarding the appropriate dose of methotrexate (MTX) required to achieve specific treatment goals in patients with rheumatoid arthritis (RA) receiving biologic drugs in Japan. The present study aimed to assess the dose-response effect of MTX in combination with adalimumab (ADA) to achieve low disease activity (LDA) and/or remission at 24 weeks in RA patients. Methods: This analysis used data of the ADA all-case survey in Japan (n = 7740), and 5494 patients who received ADA and MTX were classified into five groups by weighted average MTX dose (>0-3.2 were analyzed for effectiveness by MTX dose. Results: In biologic-naive patients (n = 1996/3097), LDA/remission rates increased with MTX up to 6-<8 mg/week and then plateaued at higher doses (LDA, p = 0.0440; remission, p = 0.0422). In biologic-exposed patients (n = 1101/3097), LDA/remission rates increased with MTX dose (LDA, p = 0.0009; remission p = 0.0143). The incidences of serious adverse drug reactions (ADRs) and serious infections did not differ by MTX dose, but total ADRs and infections were significantly higher (p < 0.05) with increased MTX doses. Conclusion: The appropriate MTX doses in combination with ADA to achieve LDA and/or remission at week 24 were different between biologic-naive and biologic-exposed patients with RA, suggesting that 8 mg/week of MTX would be enough for biologic-naive patients

Experimental Study on Lead Systems of Vectorcardiogram with Canine Homogenious Torso Model

The transfer impedance determined on Frank's lead system and McFee, Parungao's lead system using canine torso model was studied and following results were obtained. A simplyfied canine torso model was made, which was a cylinderic type imitated faithfully the transverse section in the fifth intercostal space of the canine. The canine which was used as a model has a body weight of 16.2kg. Its torso dimensions were left to right of 14.0cm, front to back of 19.0cm and height of 55.0cm. Its form was an oval on the whole shape with more gently curved surface on the front. Heart center on the dog determined by the X-ray located on the position which was 0.75cm to the left, 2.9cm to the front from the body center in the fifth intercostal soace. The definite dipole was placed on the heart center of the torso filled with 0.1% NaCl solution. Electrode position on the torso surface is defined by two quantities; levels (number 1 throngh 10) and angles in the transverse plane. The levels were separated each other at a distance of 3cm. Thus determined level 6 correspond to heart center level of the canine. The angles were taken each 5 or 10 around the cylinder whose plane passed precisely through the center of the body. Thus, potentials were determined and image surface was drawned on the loops. Image loops were oval and located on left anteriorly and slightly inferiorly from the heart center. As a result, canine image loop was found to be clearly different from the shape of the human's one which has a shape of a pear projecting slightly to the back. Then, normality and orthogonality were examined on the torso with the Frank's orthogonal lead system for human and with the McFee, Parungao's axial lead system for dog resulting the latter to be better than the former

Experimental Study on Lead Systems of Vectorcardiogram with Canine Homogenious Torso Model

The transfer impedance determined on Frank's lead system and McFee, Parungao's lead system using canine torso model was studied and following results were obtained. A simplyfied canine torso model was made, which was a cylinderic type imitated faithfully the transverse section in the fifth intercostal space of the canine. The canine which was used as a model has a body weight of 16.2kg. Its torso dimensions were left to right of 14.0cm, front to back of 19.0cm and height of 55.0cm. Its form was an oval on the whole shape with more gently curved surface on the front. Heart center on the dog determined by the X-ray located on the position which was 0.75cm to the left, 2.9cm to the front from the body center in the fifth intercostal soace. The definite dipole was placed on the heart center of the torso filled with 0.1% NaCl solution. Electrode position on the torso surface is defined by two quantities; levels (number 1 throngh 10) and angles in the transverse plane. The levels were separated each other at a distance of 3cm. Thus determined level 6 correspond to heart center level of the canine. The angles were taken each 5 or 10 around the cylinder whose plane passed precisely through the center of the body. Thus, potentials were determined and image surface was drawned on the loops. Image loops were oval and located on left anteriorly and slightly inferiorly from the heart center. As a result, canine image loop was found to be clearly different from the shape of the human's one which has a shape of a pear projecting slightly to the back. Then, normality and orthogonality were examined on the torso with the Frank's orthogonal lead system for human and with the McFee, Parungao's axial lead system for dog resulting the latter to be better than the former