Experimental Investigation of the Application of Microramp Flow Control to an Oblique Shock Interaction

The effectiveness of microramp flow control devices in controlling an oblique shock interaction was tested in the 15- by 15-Centimeter Supersonic Wind Tunnel at NASA Glenn Research Center. Fifteen microramp geometries were tested varying the height, chord length, and spacing between ramps. Measurements of the boundary layer properties downstream of the shock reflection were analyzed using design of experiments methods. Results from main effects, D-optimal, full factorial, and central composite designs were compared. The designs provided consistent results for a single variable optimization

Experimental Investigation of Normal Shock Boundary-Layer Interaction with Hybrid Flow Control

Hybrid flow control, a combination of micro-ramps and micro-jets, was experimentally investigated in the 15x15 cm Supersonic Wind Tunnel (SWT) at the NASA Glenn Research Center. Full factorial, a design of experiments (DOE) method, was used to develop a test matrix with variables such as inter-ramp spacing, ramp height and chord length, and micro-jet injection flow ratio. A total of 17 configurations were tested with various parameters to meet the DOE criteria. In addition to boundary-layer measurements, oil flow visualization was used to qualitatively understand shock induced flow separation characteristics. The flow visualization showed the normal shock location, size of the separation, path of the downstream moving counter-rotating vortices, and corner flow effects. The results show that hybrid flow control demonstrates promise in reducing the size of shock boundary-layer interactions and resulting flow separation by means of energizing the boundary layer

Politik-sensible CSR-Forschung am Beispiel der Auseinandersetzung um ein europäisches Rahmenwerk

"Der Beitrag beabsichtigt, die politische Dimension von CSR zu beleuchten, indem der Wandel der Position der Europäischen Kommission hinsichtlich CSR zwischen 2001 und 2006 als Ergebnis politischer Prozesse innerhalb einer 'issue arena' analysiert und interpretiert wird. Dabei wird auf schriftliche Dokumente der wichtigsten Akteure (EU-Kommission, EU-Parlament, EU-Rat, Interessensverbände der Wirtschaft und zivilgesellschaftliche CSR-Plattformen) sowie auf Interviews mit hochrangigen VertreterInnen dieser Institutionen (durchgeführt im Frühling 2008) zurückgegriffen." (Autorenreferat)"This contribution intends to shed light on the political dimension of CSR. We will analyze the change of the European Commission's position on CSR between 2001 and 2006 and interpret the outcome as a political process within an 'issue arena'. The analysis is based on written documents from the most important players (European Commission, European Parliament, the European Council, advocacy groups and Lobbies for industry and civil society CSR platforms) as well as interviews with high ranking representatives of these institutions (conducted in the spring of 2008)." (author's abstract

Application of Micro-ramp Flow Control Devices to an Oblique Shock Interaction

Tests are planned in the 15cm x 15cm supersonic wind tunnel at NASA Glenn to demonstrate the applicability of micro-ramp flow control to the management of shock wave boundary layer interactions. These tests will be used as a database for computational fluid dynamics (CFD) validation and Design of Experiments (DoE) design information. Micro-ramps show potential for mechanically simple and fail-safe boundary layer control

Performance of a Supersonic Over-Wing Inlet with Application to a Low-Sonic-Boom Aircraft

Development of commercial supersonic aircraft has been hindered by many related factors including fuel-efficiency, economics, and sonic-boom signatures that have prevented over-land flight. Materials, propulsion, and flight control technologies have developed to the point where, if over-land flight were made possible, a commercial supersonic transport could be economically viable. Computational fluid dynamics, and modern optimization techniques enable designers to reduce the boom signature of candidate aircraft configurations to acceptable levels. However, propulsion systems must be carefully integrated with these low-boom configurations in order that the signatures remain acceptable. One technique to minimize the downward propagation of waves is to mount the propulsion systems above the wing, such that the wing provides shielding from shock waves generated by the inlet and nacelle. This topmounted approach introduces a number of issues with inlet design and performance especially with the highly-swept wing configurations common to low-boom designs. A 1.79%-scale aircraft model was built and tested at the NASA Glenn Research Center's 8-by 6-Foot Supersonic Wind Tunnel (8x6 SWT) to validate the configuration's sonic boom signature. In order to evaluate performance of the top-mounted inlets, the starboard flow-through nacelle on the aerodynamic model was replaced by a 2.3%-scale operational inlet model. This integrated configuration was tested at the 8x6 SWT from Mach 0.25 to 1.8 over a wide range of angles-of-attack and yaw. The inlet was also tested in an isolated configuration over a smaller range of angles-of-attack and yaw. A number of boundary-layer bleed configurations were investigated and found to provide a substantial positive impact on pressure recovery and distortion. Installed inlet performance in terms of mass capture, pressure recovery, and distortion over the Mach number range at the design angle-of-attack of 4-degrees is presented herein and compared to that at 0- degrees, as well as the isolated inlet configuration to highlight installation effects. Performance of the installed inlet fell below that of the isolated inlet at Mach numbers of 1.4 and greater. The installed inlet demonstrated adequate operability over the expected range of angles-of-attack and yaw, but did exhibit definite angle-ofattack and yaw limits at supersonic conditions. At each supersonic flight Mach number, performance parameters near zero yaw angle were relatively insensitive to yaw, but in general the yaw angle yielding best performance was non-zero and varied with angle-of-attack. Performance of the installed inlet is also presented as functions of angle-of-attack and yaw to highlight these effects. Distortion at the aerodynamic interface plane ranged between 10 and 25% at the inlet critical points over the range of flight Mach numbers tested and did not decrease significantly for the isolated inlet. Although these distortion levels would be considered high for operation with a turbine engine, the over-wing installation is likely not as significant a contributor as the low test Reynolds number. This is demonstrated by comparing CFD analysis of the isolated inlet at test scale with that at intermediate and full scales

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss

The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells. BK channels have been shown to be composed of the pore-forming alpha-subunit coexpressed with the auxiliary beta-1-subunit. Analyzing the hearing function and cochlear phenotype of BK channel alpha-(BKalpha–/–) and beta-1-subunit (BKbeta-1–/–) knockout mice, we demonstrate normal hearing function and cochlear structure of BKbeta-1–/– mice. During the first 4 postnatal weeks also, BKalpha–/– mice most surprisingly did not show any obvious hearing deficits. High-frequency hearing loss developed in BKalpha–/– mice only from ca. 8 weeks postnatally onward and was accompanied by a lack of distortion product otoacoustic emissions, suggesting outer hair cell (OHC) dysfunction. Hearing loss was linked to a loss of the KCNQ4 potassium channel in membranes of OHCs in the basal and midbasal cochlear turn, preceding hair cell degeneration and leading to a similar phenotype as elicited by pharmacologic blockade of KCNQ4 channels. Although the actual link between BK gene deletion, loss of KCNQ4 in OHCs, and OHC degeneration requires further investigation, data already suggest human BK-coding slo1 gene mutation as a susceptibility factor for progressive deafness, similar to KCNQ4 potassium channel mutations. © 2004, The National Academy of Sciences. Freely available online through the PNAS open access option

Left ventricular support adjustment to aortic valve opening with analysis of exercise capacity

Background LVAD speed adjustment according to a functioning aortic valve has hypothetic advantages but could lead to submaximal support. The consequences of an open aortic valve policy on exercise capacity and hemodynamics have not yet been investigated systematically. Methods Ambulatory patients under LVAD support (INCOR®, Berlin Heart, mean support time 465 ± 257 days, average flow 4.0 ± 0.3 L/min) adjusted to maintain a near normal aortic valve function underwent maximal cardiopulmonary exercise testing (CPET) and right heart catheterization (RHC) at rest and during constant work rate exercise (20 Watt). Results Although patients (n = 8, mean age 45 ± 13 years) were in NYHA class 2, maximum work-load and peak oxygen uptake on CPET were markedly reduced with 69 ± 13 Watts (35% predicted) and 12 ± 2 mL/min/kg (38% predicted), respectively. All patients showed a typical cardiac limitation pattern and severe ventilatory inefficiency with a slope of ventilation to carbon dioxide output of 42 ± 12. On RHC, patients showed an exercise-induced increase of mean pulmonary artery pressure (from 16 ± 2.4 to 27 ± 2.8 mmHg, p < 0.001), pulmonary artery wedge pressure (from 9 ± 3.3 to 17 ± 5.3 mmHg, p = 0.01), and cardiac output (from 4.7 ± 0.5 to 6.2 ± 1.0 L/min, p = 0.008) with a corresponding slight increase of pulmonary vascular resistance (from 117 ± 35.4 to 125 ± 35.1 dyn*sec*cm−5, p = 0.58) and a decrease of mixed venous oxygen saturation (from 58 ± 6 to 32 ± 9%, p < 0.001). Conclusion An open aortic valve strategy leads to impaired exercise capacity and hemodynamics, which is not reflected by NYHA-class. Unknown compensatory mechanisms can be suspected. Further studies comparing higher vs. lower support are needed for optimization of LVAD adjustment strategies

Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data

OBJECTIVE: To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups of patients. DESIGN: Prospectively designed meta-analysis of individual patient data from prospective diagnostic accuracy studies. DATA SOURCES: Medline, Embase, and Web of Science for published studies. Unpublished studies were identified via direct contact with participating investigators. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Prospective diagnostic accuracy studies that compared coronary CTA with coronary angiography as the reference standard, using at least a 50% diameter reduction as a cutoff value for obstructive CAD. All patients needed to have a clinical indication for coronary angiography due to suspected CAD, and both tests had to be performed in all patients. Results had to be provided using 2×2 or 3×2 cross tabulations for the comparison of CTA with coronary angiography. Primary outcomes were the positive and negative predictive values of CTA as a function of clinical pretest probability of obstructive CAD, analysed by a generalised linear mixed model; calculations were performed including and excluding non-diagnostic CTA results. The no-treat/treat threshold model was used to determine the range of appropriate pretest probabilities for CTA. The threshold model was based on obtained post-test probabilities of less than 15% in case of negative CTA and above 50% in case of positive CTA. Sex, angina pectoris type, age, and number of computed tomography detector rows were used as clinical variables to analyse the diagnostic performance in relevant subgroups. RESULTS: Individual patient data from 5332 patients from 65 prospective diagnostic accuracy studies were retrieved. For a pretest probability range of 7-67%, the treat threshold of more than 50% and the no-treat threshold of less than 15% post-test probability were obtained using CTA. At a pretest probability of 7%, the positive predictive value of CTA was 50.9% (95% confidence interval 43.3% to 57.7%) and the negative predictive value of CTA was 97.8% (96.4% to 98.7%); corresponding values at a pretest probability of 67% were 82.7% (78.3% to 86.2%) and 85.0% (80.2% to 88.9%), respectively. The overall sensitivity of CTA was 95.2% (92.6% to 96.9%) and the specificity was 79.2% (74.9% to 82.9%). CTA using more than 64 detector rows was associated with a higher empirical sensitivity than CTA using up to 64 rows (93.4% v 86.5%, P=0.002) and specificity (84.4% v 72.6%, P<0.001). The area under the receiver-operating-characteristic curve for CTA was 0.897 (0.889 to 0.906), and the diagnostic performance of CTA was slightly lower in women than in with men (area under the curve 0.874 (0.858 to 0.890) v 0.907 (0.897 to 0.916), P<0.001). The diagnostic performance of CTA was slightly lower in patients older than 75 (0.864 (0.834 to 0.894), P=0.018 v all other age groups) and was not significantly influenced by angina pectoris type (typical angina 0.895 (0.873 to 0.917), atypical angina 0.898 (0.884 to 0.913), non-anginal chest pain 0.884 (0.870 to 0.899), other chest discomfort 0.915 (0.897 to 0.934)). CONCLUSIONS: In a no-treat/treat threshold model, the diagnosis of obstructive CAD using coronary CTA in patients with stable chest pain was most accurate when the clinical pretest probability was between 7% and 67%. Performance of CTA was not influenced by the angina pectoris type and was slightly higher in men and lower in older patients. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42012002780