An Examination of the Effects of Feedback Accuracy on Academic Task Acquisition in Analogue Settings

Performance feedback is a common procedure used in a variety of settings to change behavior. Although reviews of the literature have identified a number of dimensions of performance feedback that are predictive of effectiveness, little research has examined the influence of inaccurate feedback on behavior. The purpose of the present study was to examine both the short- and long-term effects of inaccurate feedback on the acquisition of match-to-sample tasks. The first study adopted a translational, human operant paradigm to evaluate the effects under highly-controlled conditions. Undergraduate students were presented an arbitrary match-to-sample task on a computer. Feedback accuracy was manipulated in an initial phase followed by a condition where only accurate feedback was provided. The second study extended these findings to a more applied setting and population. The results of both studies demonstrated that exposure to inaccurate feedback resulted in the failure to acquire the tasks. Furthermore, a carryover effect was obtained represented by a delay to acquisition following the improvement of feedback accuracy. The behavioral processes behind the results obtained are interpreted through a synthesis of literatures on performance feedback, fidelity, and instructional control. Implications for educational and organizational settings are suggested

Effects of Probabilistic Arrangements of Incentives and Disincentives on Work Task Performance in an Analogue Setting

The current study seeks to synthesize concepts from organizational behavior management and behavioral economics through an exploratory, translational paradigm. The degree to which workplace contingencies are subject to variables common to the behavioral economic literature was assessed in three experiments. The first experiment was a hypothetical discounting task that extended the cross-commodity discounting literature by comparing monetary outcomes with access to mobile devices, a potential competing reward in organizational settings. The second experiment was a systematic replication of Experiment 1 in the context of the workplace. The third experiment examined the effects of probability on the efficacy of an incentive system in an analogue work environment. The applicability of behavioral economics, specifically discounting, for organizations are discussed

Making It Easier To Be Green: A Single Case Demonstration of the Effects of Computer Defaults To Conserve Energy in a University Computer Lab

This is the publisher's version, also available electronically from http://online.liebertpub.com/doi/abs/10.1089/SUS.2013.9827Educational buildings and university campuses represent some of the most computer-dense settings in the United States. Unfortunately, the administrators and users in these settings often lack proper energy saving strategies, resulting in excessive energy waste. Research in behavioral economics has reliably shown that effort is an inhibitory factor in changing a variety of behaviors. That is, humans have a tendency to choose the option that requires the least amount of effort, regardless of whether that option is the best one. Thus, it might be inferred that interventions requiring greater effort for computer users to conserve energy are unlikely to be effective. This study highlights a successful cost-cutting application of default energy savings settings in a campus computer-testing laboratory. Default settings applied by the research team did not require effort on the part of users and resulted in computers powering-down after a relatively short period of inactivity. A cost analysis revealed modest fiscal and electricity savings among the small number of computers included in the study. However, extrapolating these modest savings across the many hundreds of work stations typically found on university campuses suggests a substantial savings would result from the adoption of the intervention described herein. Implications for practice and future research are discussed

Pathways between Primary Production and Fisheries Yields of Large Marine Ecosystems

The shift in marine resource management from a compartmentalized approach of dealing with resources on a species basis to an approach based on management of spatially defined ecosystems requires an accurate accounting of energy flow. The flow of energy from primary production through the food web will ultimately limit upper trophic-level fishery yields. In this work, we examine the relationship between yield and several metrics including net primary production, chlorophyll concentration, particle-export ratio, and the ratio of secondary to primary production. We also evaluate the relationship between yield and two additional rate measures that describe the export of energy from the pelagic food web, particle export flux and mesozooplankton productivity. We found primary production is a poor predictor of global fishery yields for a sample of 52 large marine ecosystems. However, chlorophyll concentration, particle-export ratio, and the ratio of secondary to primary production were positively associated with yields. The latter two measures provide greater mechanistic insight into factors controlling fishery production than chlorophyll concentration alone. Particle export flux and mesozooplankton productivity were also significantly related to yield on a global basis. Collectively, our analyses suggest that factors related to the export of energy from pelagic food webs are critical to defining patterns of fishery yields. Such trophic patterns are associated with temperature and latitude and hence greater yields are associated with colder, high latitude ecosystems

Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis

Current therapies for myeloproliferative neoplasms (MPNs) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem/progenitor cells (HSPCs). TAMARIN Phase-II, multicenter, single-arm clinical trial assessed tamoxifen’s safety and activity in patients with stable MPNs, no prior thrombotic events and mutated JAK2V617F, CALRins5 or CALRdel52 peripheral blood allele burden ≥20% (EudraCT 2015-005497-38). 38 patients were recruited over 112w and 32 completed 24w-treatment. The study’s A’herns success criteria were met as the primary outcome ( ≥ 50% reduction in mutant allele burden at 24w) was observed in 3/38 patients. Secondary outcomes included ≥25% reduction at 24w (5/38), ≥50% reduction at 12w (0/38), thrombotic events (2/38), toxicities, hematological response, proportion of patients in each IWG-MRT response category and ELN response criteria. As exploratory outcomes, baseline analysis of HSPC transcriptome segregates responders and non-responders, suggesting a predictive signature. In responder HSPCs, longitudinal analysis shows high baseline expression of JAK-STAT signaling and oxidative phosphorylation genes, which are downregulated by tamoxifen. We further demonstrate in preclinical studies that in JAK2V617F+ cells, 4-hydroxytamoxifen inhibits mitochondrial complex-I, activates integrated stress response and decreases pathogenic JAK2-signaling. These results warrant further investigation of tamoxifen in MPN, with careful consideration of thrombotic risk

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies

Psychological and Psychiatric Aspects of Palliative and End-of-Life Care

This chapter provides an overview of broad areas of overlap and potential synergy between the fields of psycho-oncology and palliative care. Content is aimed primarily at psycho-oncology providers—in particular, new learners or practitioners, who may have little familiarity with the field of palliative care. The chapter provides definitions that describe the two fields, highlights conceptual and practical areas of commonality, and reviews several psychological and psychiatric considerations that are particularly pertinent to taking care of patients in palliative care settings. As palliative care integration increasingly becomes the norm in oncologic care, there will be growing opportunities for palliative care and psycho-oncology providers to explore and develop models of collaboration and partnership that enhance the care of shared patients

Cork-in-bottle mechanism of inhibitor binding to mammalian complex I.

Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a major contributor of free energy for oxidative phosphorylation, is increasingly recognized as a promising drug target for ischemia-reperfusion injury, metabolic disorders, and various cancers. Several pharmacologically relevant but structurally unrelated small molecules have been identified as specific complex I inhibitors, but their modes of action remain unclear. Here, we present a 3.0-Å resolution cryo-electron microscopy structure of mammalian complex I inhibited by a derivative of IACS-010759, which is currently in clinical development against cancers reliant on oxidative phosphorylation, revealing its unique cork-in-bottle mechanism of inhibition. We combine structural and kinetic analyses to deconvolute cross-species differences in inhibition and identify the structural motif of a "chain" of aromatic rings as a characteristic that promotes inhibition. Our findings provide insights into the importance of π-stacking residues for inhibitor binding in the long substrate-binding channel in complex I and a guide for future biorational drug design