103 research outputs found
Computational modelling of a multifield single-crystal gradient plasticity formulation
A model of higher-order single crystal plasticity is presented and reviewed in order to develop a corresponding finite-element framework. Contrary to the underlying model of Gurtin [Int. J. Plast. 24:702-725, 2008], here rather than the slip rate, the slip and its gradient constitute primary micro state variables. The resulting rate-dependent formulation accounts for size effects through the free energy depending on density of geometrically necessary dislocations. The relationship to multifield theories of continua with microstructure is pointed out. With the presented finite-element approach, the corresponding fully coupled initial-boundary value problem is solved monolithically, and features of the model are illustrated in two preliminary numerical example
Computational and theoretical aspects of a grain-boundary model that accounts for grain misorientation and grain-boundary orientation
A detailed theoretical and numerical investigation of the infinitesimal
single-crystal gradient plasticity and grain-boundary theory of Gurtin (2008)
"A theory of grain boundaries that accounts automatically for grain
misorientation and grain-boundary orientation". Journal of the Mechanics and
Physics of Solids 56 (2), 640-662, is performed. The governing equations and
flow laws are recast in variational form. The associated incremental problem is
formulated in minimization form and provides the basis for the subsequent
finite element formulation. Various choices of the kinematic measure used to
characterize the ability of the grain boundary to impede the flow of
dislocations are compared. An alternative measure is also suggested. A series
of three-dimensional numerical examples serve to elucidate the theory
Symmetry and topology in antiferromagnetic spintronics
Antiferromagnetic spintronics focuses on investigating and using
antiferromagnets as active elements in spintronics structures. Last decade
advances in relativistic spintronics led to the discovery of the staggered,
current-induced field in antiferromagnets. The corresponding N\'{e}el
spin-orbit torque allowed for efficient electrical switching of
antiferromagnetic moments and, in combination with electrical readout, for the
demonstration of experimental antiferromagnetic memory devices. In parallel,
the anomalous Hall effect was predicted and subsequently observed in
antiferromagnets. A new field of spintronics based on antiferromagnets has
emerged. We will focus here on the introduction into the most significant
discoveries which shaped the field together with a more recent spin-off
focusing on combining antiferromagnetic spintronics with topological effects,
such as antiferromagnetic topological semimetals and insulators, and the
interplay of antiferromagnetism, topology, and superconductivity in
heterostructures.Comment: Book chapte
The significance of consciousness studies and quantum physics for creating a spiritual research paradigm
Dynamic Diagnosis of Familial Prion Diseases Supports the β2-α2 Loop as a Universal Interference Target
[Background]
Mutations in the cellular prion protein associated to familial prion disorders severely increase the likelihood of its misfolding into pathogenic conformers. Despite their postulation as incompatible elements with the native fold, these mutations rarely modify the native state structure. However they variably have impact on the thermodynamic stability and metabolism of PrPC and on the properties of PrPSc aggregates. To investigate whether the pathogenic mutations affect the dynamic properties of the HuPrP(125-229) α-fold and find possible common patterns of effects that could help in prophylaxis we performed a dynamic diagnosis of ten point substitutions.[Methodology/Principal Findings]
Using all-atom molecular dynamics simulations and novel analytical tools we have explored the effect of D178N, V180I, T183A, T188K, E196K, F198S, E200K, R208H, V210I and E211Q mutations on the dynamics of HuPrP(125-228) α-fold. We have found that while preserving the native state, all mutations produce dynamic changes which perturb the coordination of the α2-α3 hairpin to the rest of the molecule and cause the reorganization of the patches for intermolecular recognition, as the disappearance of those for conversion inhibitors and the emergence of an interaction site at the β2-α2 loop region.[Conclusions/Significance]
Our results suggest that pathogenic mutations share a common pattern of dynamical alterations that converge to the conversion of the β2-α2 loop into an interacting region that can be used as target for interference treatments in genetic diseases.This work was supported in parts by grants BFU2009-07971 from the MICINN (MG), FundaciÃ3n Cien (MG); Fondazione Cariplo (GC) and AIRC (GC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding received for this study.Peer reviewe
Conceiving “personality”: Psychologist’s challenges and basic fundamentals of the Transdisciplinary Philosophy-of-Science Paradigm for Research on Individuals
Scientists exploring individuals, as such scientists are individuals themselves and thus not independent from their objects of research, encounter profound challenges; in particular, high risks for anthropo-, ethno- and ego-centric biases and various fallacies in reasoning. The Transdisciplinary Philosophy-of-Science Paradigm for Research on Individuals (TPS-Paradigm) aims to tackle these challenges by exploring and making explicit the philosophical presuppositions that are being made and the metatheories and methodologies that are used in the field. This article introduces basic fundamentals of the TPS-Paradigm including the epistemological principle of complementarity and metatheoretical concepts for exploring individuals as living organisms. Centrally, the TPS-Paradigm considers three metatheoretical properties (spatial location in relation to individuals’ bodies, temporal extension, and physicality versus “non-physicality”) that can be conceived in different forms for various kinds of phenomena explored in individuals (morphology, physiology, behaviour, the psyche, semiotic representations, artificially modified outer appearances and contexts). These properties, as they determine the phenomena’s accessibility in everyday life and research, are used to elaborate philosophy-of-science foundations and to derive general methodological implications for the elementary problem of phenomenon-methodology matching and for scientific quantification of the various kinds of phenomena studied. On the basis of these foundations, the article explores the metatheories and methodologies that are used or needed to empirically study each given kind of phenomenon in individuals in general. Building on these general implications, the article derives special implications for exploring individuals’ “personality”, which the TPS-Paradigm conceives of as individual-specificity in all of the various kinds of phenomena studied in individuals
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
Computational modelling of a multifield single-crystal gradient plasticity formulation
A model of higher-order single crystal plasticity is presented and reviewed in order to develop a corresponding finite-element framework. Contrary to the underlying model of Gurtin [Int. J. Plast. 24:702-725, 2008], here rather than the slip rate, the slip and its gradient constitute primary micro state variables. The resulting rate-dependent formulation accounts for size effects through the free energy depending on density of geometrically necessary dislocations. The relationship to multifield theories of continua with microstructure is pointed out. With the presented finite-element approach, the corresponding fully coupled initial-boundary value problem is solved monolithically, and features of the model are illustrated in two preliminary numerical example
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