808 research outputs found
De spiegel van Straatsburg
Criminal Justice: Legitimacy, accountability, and effectivit
Simulating `Complex' Problems with Quantum Monte Carlo
We present a new quantum Monte Carlo algorithm suitable for generically
complex problems, such as systems coupled to external magnetic fields or anyons
in two spatial dimensions. We find that the choice of gauge plays a nontrivial
role, and can be used to reduce statistical noise in the simulation.
Furthermore, it is found that noise can be greatly reduced by approximate
cancellations between the phases of the (gauge dependent) statistical flux and
the external magnetic flux.Comment: Revtex, 11 pages. 3 postscript files for figures attache
Small Fermi energy and phonon anharmonicity in MgB_2 and related compounds
The remarkable anharmonicity of the E_{2g} phonon in MgB_2 has been suggested
in literature to play a primary role in its superconducting pairing. We
investigate, by means of LDA calculations, the microscopic origin of such an
anharmonicity in MgB_2, AlB_2, and in hole-doped graphite. We find that the
anharmonic character of the E_{2g} phonon is essentially driven by the small
Fermi energy of the sigma holes. We present a simple analytic model which
allows us to understand in microscopic terms the role of the small Fermi energy
and of the electronic structure. The relation between anharmonicity and
nonadiabaticity is pointed out and discussed in relation to various materials.Comment: 5 pages, 2 figures replaced with final version, accepted on Physical
Review
Competition between spin and charge polarized states in nanographene ribbons with zigzag edges
Effects of the nearest neighbor Coulomb interaction on nanographene ribbons
with zigzag edges are investigated using the extended Hubbard model within the
unrestricted Hartree-Fock approximation. The nearest Coulomb interaction
stabilizes a novel electronic state with the opposite electric charges
separated and localized along both edges, resulting in a finite electric dipole
moment pointing from one edge to the other. This charge-polarized state
competes with the peculiar spin-polarized state caused by the on-site Coulomb
interaction and is stabilized by an external electric field.Comment: 4 pages; 4 figures; accepted for publication in Phys. Rev. B; related
Web site: http://staff.aist.go.jp/k.harigaya/index_E.htm
Triplet superconductivity in quasi one-dimensional systems
We study a Hubbard hamiltonian, including a quite general nearest-neighbor
interaction, parametrized by repulsion V, exchange interactions Jz, Jperp,
bond-charge interaction X and hopping of pairs W. The case of correlated
hopping, in which the hopping between nearest neighbors depends upon the
occupation of the two sites involved, is also described by the model for
sufficiently weak interactions. We study the model in one dimension with usual
continuum-limit field theory techniques, and determine the phase diagram. For
arbitrary filling, we find a very simple necessary condition for the existence
of dominant triplet superconducting correlations at large distance in the spin
SU(2) symmetric case: 4V+J<0. In the correlated hopping model, the three-body
interaction should be negative for positive V. We also compare the predictions
of this weak-coupling treatment with numerical exact results for the
correlated-hopping model obtained by diagonalizing small chains, and using
novel techniques to determine the opening of the spin gap.Comment: 8 pages, 3 figure
Bosonic representation of one-dimensional Heisenberg ferrimagnets
The energy structure and the thermodynamics of ferrimagnetic Heisenberg
chains of alternating spins S and s are described in terms of the Schwinger
bosons and modified spin waves. In the Schwinger representation, we average the
local constraints on the bosons and diagonalize the Hamiltonian at the
Hartree-Fock level. In the Holstein-Primakoff representation, we optimize the
free energy in two different ways introducing an additional constraint on the
staggered magnetization. A new modified spin-wave scheme, which employs a
Lagrange multiplier keeping the native energy structure free from temperature
and thus differs from the original Takahashi Scheme, is particularly stressed
as an excellent language to interpret one-dimensional quantum ferrimagnetism.
Other types of one-dimensional ferrimagnets and the antiferromagnetic limit S=s
are also mentioned.Comment: to be published in Phys. Rev. B 69, No. 6, 0644XX (2004
Ordering and Fluctuation of Orbital and Lattice Distortion in Perovskite Manganese Oxides
Roles of orbital and lattice degrees of freedom in strongly correlated
systems are investigated to understand electronic properties of perovskite Mn
oxides such as La_{1-x}Sr_{x}MnO_{3}. An extended double-exchange model
containing Coulomb interaction, doubly degenerate orbitals and Jahn-Teller
coupling is derived under full polarization of spins with two-dimensional
anisotropy. Quantum fluctuation effects of Coulomb interaction and orbital
degrees of freedom are investigated by using the quantum Monte Carlo method. In
undoped states, it is crucial to consider both the Coulomb interaction and the
Jahn-Teller coupling in reproducing characteristic hierarchy of energy scales
among charge, orbital-lattice and spin degrees of freedom in experiments. Our
numerical results quantitatively reproduce the charge gap amplitude as well as
the stabilization energy and the amplitude of the cooperative Jahn-Teller
distortion in undoped compounds. Upon doping of carriers, in the absence of the
Jahn-Teller distortion, critical enhancement of both charge compressibility and
orbital correlation length is found with decreasing doping concentration. These
are discussed as origins of strong incoherence in charge dynamics. With the
Jahn-Teller coupling in the doped region, collapse of the Jahn-Teller
distortion and instability to phase separation are obtained and favorably
compared with experiments. These provide a possible way to understand the
complicated properties of lightly doped manganites.Comment: 22 pages RevTeX including 25 PS figures, submitted to Phys.Rev.B,
replaced version; two figures are replaced by Fig.17 with minor changes in
the tex
The (muon^-,muon^+) conversion in nuclei as a probe of new physics
A detailed study of the muonic analogue of neutrinoless double beta decay,
(muon^-,muon^+) conversion, has been carried out for the A=44 nuclear system.
We studied several lepton number violating (LNV) mechanisms potentially
triggering this process: exchange by light and heavy Majorana neutrinos as well
as exchange by supersymmetric particles participating in R-parity violating
interactions. The nuclear structure has been taken into account within the
renormalized Quasiparticle Random Phase Approximation method. To our knowledge,
this is the first realistic treatment of nuclear structure aspects of the
(muon^-,muon^+) conversion. We estimated the rate of this process utilizing the
existing experimental constraints on the parameters of the underlying LNV
interactions and conclude that the (muon^-,muon^+) conversion is hardly
detectable in the near future experiments.Comment: 23 pages, RevTex, 3 Postscript figure
Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy
Equine recurrent uveitis (ERU) is a spontaneous, painful, and vision threatening disease affecting up to 25% of equine populations worldwide. Current treatments of ERU are nonspecific and have many side effects which limits them to short-term use. In order to develop an effective therapy for ERU, we investigated the use of adeno-associated virus (AAV) gene therapy, exploiting a natural immune tolerance mechanism induced by equine interleukin-10 (Equine-IL10). The purpose of this study was to evaluate the therapeutic efficacy of a single intravitreal (IVT) dose of AAV8-Equine-IL10 gene therapy for inhibition of experimental autoimmune uveitis (EAU) in rats. Each rat was dosed intravitreally (IVT) in both eyes with either balanced salt solution (BSS) (control; n = 4), AAV8-Equine-IL10 at a low dose (2.4x109 vg; n = 5) or high dose (2.4x1010 vg; n = 5). EAU was induced in all groups of rats 7 days after IVT injections and euthanized 21 days post-injection. Ophthalmic examination and aqueous humor (AH) cell counts were recorded with the observer blinded to the treatment groups. Histopathology and qPCR were performed on selected ocular tissues. Data presented herein demonstrate that AAV8-Equine-IL10 treated rats exhibited a significant decrease in clinical inflammatory scores and AH cell counts compared to BSS-treated EAU eyes on days 10, 12 and 14 post EAU induction at both administered vector doses. Mean cellular histologic infiltrative scores were also significantly less in AAV8-Equine-IL10 dosed rats compared to the BSS group. Intravitreal injection of AAV8-Equine-IL10 resulted in Equine-IL10 cDNA expression in the ciliary body, retina, cornea, and optic nerve in a dose-dependent manner. A single IVT injection of AAV8-Equine-IL10 appeared to be well-tolerated and inhibited EAU even at the lowest administered dose. These results demonstrate safety and efficacy of AAV8-Equine-IL10 to prevent EAU and support continued exploration of AAV gene therapy for the treatment of equine and perhaps human recurrent uveitis
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