393 research outputs found

    “You're Really Gonna Kick Us All Out?” Sustaining Safe Spaces for Community-Based HIV Prevention and Control among Black Men Who Have Sex with Men

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    Black men who have sex with men (BMSM) experience among the highest rates of HIV infection in the United States. We conducted a community-based ethnography in New York City to identify the structural and environmental factors that influence BMSMs vulnerability to HIV and their engagement with HIV prevention services. Methods included participant observation at community-based organizations (CBOs) in New York City, in-depth interviews with 31 BMSM, and 17 key informant interviews. Our conceptual framework shows how creating and sustaining safe spaces could be a critical environmental approach to reduce vulnerability to HIV among BMSM. Participant observation, in-depth and key informant interviews revealed that fear and mistrust characterized men’s relation to social and public institutions, such as churches, schools, and the police. This fear and mistrust created HIV vulnerability among the BMSM in our sample by challenging engagement with services. Our findings suggest that to be successful, HIV prevention efforts must address these structural and environmental vulnerabilities. Among the CBOs that we studied, “safe spaces” emerged as an important tool for addressing these environmental vulnerabilities. CBOs used safe spaces to provide social support, to address stigma, to prepare men for the workforce, and to foster a sense of community among BMSM. In addition, safe spaces were used for HIV and STI testing and treatment campaigns. Our ethnographic findings suggest that safe spaces represent a promising but so far under-utilized part of HIV prevention infrastructure. Safe spaces seem integral to high impact comprehensive HIV prevention efforts, and may be considered more appropriately as part of HIV capacity-building rather than being nested within program-specific funding structures

    Structural barriers to HIV prevention among men who have sex with men (MSM) in Vietnam: Diversity, stigma, and healthcare access

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    Men who have sex with men (MSM) in Vietnam experience disproportionate rates of HIV infection. To advance understanding of how structural barriers may shape their engagement with HIV prevention services, we draw on 32 in-depth interviews and four focus groups (n = 31) conducted with MSM in Hanoi between October 2015- March 2016. Three primary factors emerged: (1) Diversity, both in relation to identity and income; Vietnamese MSM described themselves as segregated into BĂłng kĂ­n (hidden, often heterosexually-identified MSM) and BĂłng lộ (‘out,’ transgender, or effeminate MSM). Lower-income, ‘hidden’ MSM from rural areas were reluctant to access MSM-targeted services; (2) Stigma: MSM reported being stigmatized by the healthcare system, family, and other MSM; and (3) Healthcare access: this was limited due to economic barriers and lack of MSM-friendly services. Our research suggests the need for multiple strategies to reach diverse types of MSM as well as to address barriers in access to health services such as stigma and costs. While a great deal has been written about the diversity of MSM in relation to gender performance and sexual identities, our research points to the substantial structural-level barriers that must be addressed in order to achieve meaningful and effective HIV prevention for MSM worldwide

    A low cost high flux solar simulator

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    A low cost, high flux, large area solar simulator has been designed, built and characterized for the purpose of studying optical melting and light absorption behavior of molten salts. Seven 1500 W metal halide outdoor stadium lights are used as the light source to simulate concentrating solar power (CSP) heliostat output. Metal halide bulbs and ballasts are far less costly per-watt than typical xenon arc lamp solar simulator light sources. They provide a satisfactory match to natural sunlight; although ‘unfiltered’ metal halide lights have irradiance peaks between 800 and 1000 nm representing an additional 5% of measured energy output as compared to terrestrial solar irradiance over the same range. With the use of a secondary conical concentrator, output fluxes of approximately 60 kW/m[superscript 2] (60 suns) peak and 45 kW/m[superscript 2] (45 suns) average are achieved across a 38 cm diameter output aperture. Unique to the design of this simulator, the tilt angle and distance between the output aperture and the ground are adjustable to accommodate test receivers of varying geometry. Use of off-the-shelf structural, lighting and electrical components keeps the fabrication cost below $10,000

    "I Didn't Want To Be 'That Girl'": The Social Risks of Labeling, Telling, and Reporting Sexual Assault

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    This article deploys ethnographic data to explain why some students do not label experiences as sexual assault or report those experiences. Using ideas of social risks and productive ambiguities, it argues that not labeling or reporting assault can help students (1) sustain their current identities and allow for several future ones, (2) retain their social relationships and group affiliations while maintaining the possibility of developing a wider range of future ones, or (3) avoid derailing their current or future goals within the higher educational setting, or what we call "college projects." Conceptually, this work advances two areas of sociological research. First, it expands the framework of social risks, or culturally specific rationales for seemingly illogical behavior, by highlighting the interpersonal and institutional dimensions of such risks. Second, it urges researchers to be more attentive to contexts in which categorical ambiguity or denial is socially productive and to take categorical avoidance seriously as a subject of inquiry. Substantively, this work advances knowledge of why underreporting of campus sexual assault occurs, with implications for institutional policies to support students who have experienced unwanted nonconsensual sex regardless of how those students may label what happened

    Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1

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    SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr (Vpx/Vpr), which target SAMHD1 for proteasome-mediated degradation. However, the precise determinants within SAMHD1 for recognition by Vpx/Vpr remain unclear. Here we show that evolution of Vpx/Vpr in primate lentiviruses has caused the interface between SAMHD1 and Vpx/Vpr to alter during primate lentiviral evolution. Using multiple HIV-2 and SIV Vpx proteins, we show that Vpx from the HIV-2 and SIVmac lineage, but not Vpx from the SIVmnd2 and SIVrcm lineage, require the C-terminus of SAMHD1 for interaction, ubiquitylation, and degradation. On the other hand, the N-terminus of SAMHD1 governs interactions with Vpx from SIVmnd2 and SIVrcm, but has little effect on Vpx from HIV-2 and SIVmac. Furthermore, we show here that this difference in SAMHD1 recognition is evolutionarily dynamic, with the importance of the N- and C-terminus for interaction of SAMHD1 with Vpx and Vpr toggling during lentiviral evolution. We present a model to explain how the head-to-tail conformation of SAMHD1 proteins favors toggling of the interaction sites by Vpx/Vpr during this virus-host arms race. Such drastic functional divergence within a lentiviral protein highlights a novel plasticity in the evolutionary dynamics of viral antagonists for restriction factors during lentiviral adaptation to its hosts. © 2013 Fregoso et al
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