Belief Semantics of Authorization Logic

Authorization logics have been used in the theory of computer security to reason about access control decisions. In this work, a formal belief semantics for authorization logics is given. The belief semantics is proved to subsume a standard Kripke semantics. The belief semantics yields a direct representation of principals' beliefs, without resorting to the technical machinery used in Kripke semantics. A proof system is given for the logic; that system is proved sound with respect to the belief and Kripke semantics. The soundness proof for the belief semantics, and for a variant of the Kripke semantics, is mechanized in Coq

Nexus Authorization Logic (NAL): Logical Results

Nexus Authorization Logic (NAL) [Schneider et al. 2011] is a logic for reasoning about authorization in distributed systems. A revised version of NAL is given here, including revised syntax, a revised proof theory using localized hypotheses, and a new Kripke semantics. The proof theory is proved sound with respect to the semantics, and that proof is formalized in Coq

Semantics for Noninterference with Interaction Trees

Noninterference is the strong information-security property that a program does not leak secrets through publicly-visible behavior. In the presence of effects such as nontermination, state, and exceptions, reasoning about noninterference quickly becomes subtle. We advocate using interaction trees (ITrees) to provide compositional mechanized proofs of noninterference for multi-language, effectful, nonterminating programs, while retaining executability of the semantics. We develop important foundations for security analysis with ITrees: two indistinguishability relations, leading to two standard notions of noninterference with adversaries of different strength, along with metatheory libraries for reasoning about each. We demonstrate the utility of our results using a simple imperative language with embedded assembly, along with a compiler into that assembly language

Semantics for Noninterference with Interaction Trees (Artifact)

Noninterference is the strong information-security property that a program does not leak secrets through publicly-visible behavior. In the presence of effects such as nontermination, state, and exceptions, reasoning about noninterference quickly becomes subtle. We advocate using interaction trees (ITrees) to provide compositional mechanized proofs of noninterference for multi-language, effectful, nonterminating programs, while retaining executability of the semantics. We develop important foundations for security analysis with ITrees: two indistinguishability relations, leading to two standard notions of noninterference with adversaries of different strength, along with metatheory libraries for reasoning about each. We demonstrate the utility of our results using a simple imperative language with embedded assembly, along with a compiler into that assembly language

The Interrelations Between Spiritual Well-Being, Pain Interference and Depressive Symptoms in Patients with Multiple Sclerosis

Depressive symptoms are common in individuals with multiple sclerosis (MS), and are frequently exacerbated by pain; however, spiritual well-being may allow persons with MS to more effectively cope with pain-related deficits in physical and role functioning. We explored the associations between spiritual well-being, pain interference and depressive symptoms, assessing each as a potential mediator, in eighty-one patients being treated for MS, who completed self-report measures: Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale, Pain Effects Scale, and Center for Epidemiologic Studies Depression Scale Revised. At the bivariate level, spiritual well-being and its subscale of meaning and peace were negatively associated with depression and pain interference. In mediation models, depression was not related to pain interference via spiritual well-being, or to spiritual well-being via pain interference. Pain interference was related to depression via spiritual well-being and meaning/peace, and to spiritual well-being and meaning/peace via depressive symptoms. Finally, spiritual well-being and meaning/peace were related to depression via pain interference, and to pain interference via depressive symptoms. For patients with MS, a multi-faceted approach to treatment that includes pain reduction and promotion of spiritual well-being may be beneficial, although amelioration of depression remains a critical task

First-Order Logic for Flow-Limited Authorization

We present the Flow-Limited Authorization First-Order Logic (FLAFOL), a logic for reasoning about authorization decisions in the presence of information-flow policies. We formalize the FLAFOL proof system, characterize its proof-theoretic properties, and develop its security guarantees. In particular, FLAFOL is the first logic to provide a non-interference guarantee while supporting all connectives of first-order logic. Furthermore, this guarantee is the first to combine the notions of non-interference from both authorization logic and information-flow systems. All theorems in this paper are proven in Coq.Comment: Coq code can be found at https://github.com/FLAFOL/flafol-co

Synthesis of a fullerene-based one-dimensional nanopolymer through topochemical transformation of the parent nanowire

Large-scale practical applications of fullerene (C60) in nanodevices could be significantly facilitated if the commercially-available micrometer-scale raw C60 powder were further processed into a one-dimensional (1D) nanowire-related polymer displaying covalent bonding as molecular interlinks and resembling traditional important conjugated polymers. However, there has been little study thus far in this area despite the abundant literature on fullerene. Here we report the synthesis and characterization of such a C60-based nanowire polymer, (-C60TMB-)n, where TMB=1,2,4-trimethylbenzene, which displays a well-defined crystalline structure, exceptionally large length-to-width ratio and excellent thermal stability. The material is prepared by first growing the corresponding nanowire through a solution phase of C60 followed by a topochemical polymerization reaction in the solid state. Gas chromatography, mass spectrometry and 13C nuclear magnetic resonance evidence is provided for the nature of the covalent bonding mode adopted by the polymeric chains. Theoretical analysis based on detailed calculations of the reaction energetics and structural analysis provides an in-depth understanding of the polymerization pathway. The nanopolymer promises important applications in biological fields and in the development of optical, electrical, and magnetic nanodevices.Comment: 30 pages, 12 figures, 2 table

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation

Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with the MHC class I antigen processing pathway during the lytic replication cycle. We have now identified a novel role for the lytic cycle gene, BILF1, which encodes a glycoprotein with the properties of a constitutive signaling G-protein-coupled receptor (GPCR). BILF1 reduced the levels of MHC class I at the cell surface and inhibited CD8+ T cell recognition of endogenous target antigens. The underlying mechanism involves physical association of BILF1 with MHC class I molecules, an increased turnover from the cell surface, and enhanced degradation via lysosomal proteases. The BILF1 protein of the closely related CeHV15 c1-herpesvirus of the Rhesus Old World primate (80% amino acid sequence identity) downregulated surface MHC class I similarly to EBV BILF1. Amongst the human herpesviruses, the GPCR encoded by the ORF74 of the KSHV c2-herpesvirus is most closely related to EBV BILF1 (15% amino acid sequence identity) but did not affect levels of surface MHC class I. An engineered mutant of BILF1 that was unable to activate G protein signaling pathways retained the ability to downregulate MHC class I, indicating that the immune-modulating and GPCR-signaling properties are two distinct functions of BILF1. These findings extend our understanding of the normal biology of an important human pathogen. The discovery of a third EBV lytic cycle gene that cooperates to interfere with MHC class I antigen processing underscores the importance of the need for EBV to be able to evade CD8+ T cell responses during the lytic replication cycle, at a time when such a large number of potential viral targets are expressed