Path-Integral Formulation of Casimir Effects in Supersymmetric Quantum Electrodynamics

The Casimir effect is an interesting phenomenon in the sense that it provides us with one of the primitive means of extracting the energy out of the vacuum. Since the original work of Casimir a number of works have appeared in extending the result to the case of more general topological and dynamical configurations of the boundary condition and to the circumstances at finite temperature and gravity. In the studies of the Casimir effects it is common to assume the free electromagnetic field in the bounded region. It may be interesting to extend our arguments for fields other than the electromagnetic field. The Casimir effect due to the free fermionic fields has been investigated by several authors and has been found to result in an attractive force under the suitable physical boundary conditions.Comment: 12 pages, 6 figures, REVTe

Reaction Heat Effects on Initial Linear Shrinkage and Deformation in Stereolithography

In the industrial use of stereolithography, precision is always a problem. The basic phenomenon of solidification shrinkage has not been sufficiently investigated. This study aims at clarifying the initial linear shrinkage of cured resin in a minute volume. Experimental equipment has been developed which measures the time history of the single strand in situ in a stereolithography machine. An analysis model of the time history of a minute volume linear shrinkage was shown using the measured shrinkage of a cured line segment. The relation between the time history of the linear shrinkage and temperature was measured and the shrinkage in the minute volume after irradiation was found to result due to temperature variation. Deformation and linear shrinkage were measured with two scanning orders to control the thermal distribution in layer forming. The effects of thermal distribution were also observed in one layer forming

Reaction Heat Effect On Initial Linear Shrinkage of Sterelothigraphy Resins

In the industrial use ofthe Stereolithography, the precision is always a problem. Basic phenomenon of the solidification shrink has not suffiCiently investigated This study aims at clarifying the initial linear shrinkage ofcured resin in a minute volume. Experimental equipment has been developed which measures the time history of the single strand in situ in a stereolithography machine. Analysis model about the time history of a minute volume linear shrinkage has been shown using with the measured shrinkage of a cured line segment. The relation between the time history ofthe linear shrinkage and the temperature was measured and the shrinkage in the minute volume after irradiation has been caused by the temperature variationMechanical Engineerin

Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs

Abstractα-Tocopherol transfer protein (αTTP), a product of the gene which causes familial isolated vitamin E deficiency, plays an important role in determining the plasma vitamin E level. We examined the structural characteristics of vitamin E analogs required for recognition by αTTP. Ligand specificity was assessed by evaluating the competition of non-labeled vitamin E analogs and α-[3H]tocopherol for transfer between membranes in vitro. Relative affinities (RRR-α-tocopherol=100%) calculated from the degree of competition were as follows: β-tocopherol, 38%; γ-tocopherol, 9%; δ-tocopherol, 2%; α-tocopherol acetate, 2%; α-tocopherol quinone, 2%; SRR-α-tocopherol, 11%; α-tocotrienol, 12%; trolox, 9%. Interestingly, there was a linear relationship between the relative affinity and the known biological activity obtained from the rat resorption-gestation assay. From these observations, we conclude that the affinity of vitamin E analogs for αTTP is one of the critical determinants of their biological activity

Risk factors of recurrent lumbar disk herniation: A single center study and review of the literature

Background: The recurrence of lumbar disk herniation (LDH) is a major problem in the treatment of LDH. The purpose of this study was to investigate the risk factors for recurrent LDH. Methods: Between April 2005 and March 2008, 298 patients with LDH, who underwent surgical treatment, were enrolled in this study. The patients were divided into a nonrecurrent group (N group) and a recurrent group (R group). We compared their clinical parameters including age, sex, body mass index, smoking, alcohol, sports activity, occupational lifting, and occupational driving. The relationships between the variables and recurrent LDH were evaluated by univariate analysis and multiple logistic regression analysis. Results: The N group had 266 patients (89.3%) and the R group had 32 patients (10.7%). Univariate analysis showed that current smoking (P<0.001) and occupational lifting (P=0.02) significantly correlated with recurrent LDH. Multivariate analysis showed that current smoking significantly related with recurrent LDH (OR, 3.47; 95% CI, 1.55-7.80; P=0.003). Conclusions: Our study suggests that smoking cessation and restraining from lifting may significantly decrease the incidence of recurrent LDH. © 2013 Wolters Kluwer Health, Inc. All rights reserved

Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.

Adult pleomorphic rhabdomyosarcoma (RMS) is a rare and recalcitrant, highly-malignant mesenchymal tumor in need of improved therapeutic strategies. Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude mouse model with the technique of surgical orthotopic implantation (SOI). We previously described the development of a PDOX model of adult pleomorphic RMS where the tumor behaved similar to the patient donor. A high-grade pleomorphic rhabdomyosarcoma from a striated muscle was previously grown orthotopically in the right biceps-femoris muscle of nude mice to establish the PDOX model. In the present study, the PDOX models were randomized into the following treatment groups when tumor volume reached 100 mm3: G1, control without treatment; G2, cyclophosphamide (CPA) 140 mg/kg, intraperitoneal (i.p.) injection, weekly, for 3 weeks; G3, temozolomide (TEM), 25 mg/kg, per oral (p.o.), daily, for 21 days; G4, temozolomide (TEM) 25 mg/kg, p.o., daily, for 21 days combined with irinotecan (IRN), 4 mg/kg, i.p., daily for 21 days. After 3 weeks, treatment of PDOX with TEM combined with IRN was so powerful that it resulted in tumor regression and the smallest tumor volume compared to other groups. The RMS PDOX model should be of use to design the treatment program for the patient and for drug discovery and evaluation for this recalcitrant tumor type

Organelle Optogenetics: Direct Manipulation of Intracellular Ca2+ Dynamics by Light

As one of the ubiquitous second messengers, the intracellular Ca2+, has been revealed to be a pivotal regulator of various cellular functions. Two major sources are involved in the initiation of Ca2+-dependent signals: influx from the extracellular space and release from the intracellular Ca2+ stores such as the endoplasmic/sarcoplasmic reticulum (ER/SR). To manipulate the Ca2+ release from the stores under high spatiotemporal precision, we established a new method termed “organelle optogenetics.” That is, one of the light-sensitive cation channels (channelrhodopsin-green receiver, ChRGR), which is Ca2+-permeable, was specifically targeted to the ER/SR. The expression specificity as well as the functional operation of the ER/SR-targeted ChRGR (ChRGRER) was evaluated using mouse skeletal myoblasts (C2C12): (1) the ChRGRER co-localized with the ER-marker KDEL; (2) no membrane current was generated by light under whole-cell clamp of cells expressing ChRGRER; (3) an increase of fluorometric Ca2+ was evoked by the optical stimulation (OS) in the cells expressing ChRGRER in a manner independent on the extracellular Ca2+ concentration ([Ca2+]o); (4) the ΔF/F0 was sensitive to the inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and (5) the store-operated Ca2+ entry (SOCE) was induced by the OS in the ChRGRER-expressing cells. Our organelle optogenetics effectively manipulated the ER/SR to release Ca2+ from intracellular stores. The use of organelle optogenetics would reveal the neuroscientific significance of intracellular Ca2+ dynamics under spatiotemporal precision