DIFFERENCES IN LOWER LEG KINETIC OF SOCCER INSTEP KICKING BETWEEN FEMALE AND MALE PLAYERS

We aimed to clarify the difference in lower leg segment kinetics of soccer instep kicking between female and male players. Instep kicking of seven female and seven male university soccer players were captured at 500Hz. There was no significant difference between female and male groups for peak forward lower leg angular velocity while female players exhibited significantly smaller angular impulse due to knee joint moment than that of male players. On the other hand, female players showed comparable angular impulse due to the interaction moment acting on the lower leg to that of male players. It can be considered that the interaction moment acting on the lower leg of female players may compensate their reduced exertion of knee joint moment during kicking, thereby achieving comparable lower leg angular velocity to that of male players

The Practice of Basic Informatics 2020

Version 2020/04/02Kyoto University provides courses on 'The Practice of Basic Informatics' as part of its Liberal Arts and Sciences Program. The course is taught at many schools and departments, and course contents vary to meet the requirements of these schools and departments. This textbook is made open to the students of all schools that teach these courses. As stated in Chapter 1, this book is written with the aim of building ICT skills for study at university, that is, ICT skills for academic activities. Some topics may not be taught in class. However, the book is written for self-study by students. We include many exercises in this textbook so that instructors can select some of them for their classes, to accompany their teaching plans. The courses are given at the computer laboratories of the university, and the contents of this textbook assume that Windows 10 and Microsoft Office 2016 are available in these laboratories. In Chapter 13, we include an introduction to computer programming; we chose Python as the programming language because on the one hand it is easy for beginners to learn, and on the other, it is widely used in academic research. To check the progress of students' self-study, we have attached assessment criteria (a 'rubric') of this course as an Appendix. Current ICT is a product of the endeavors of many people. The "Great Idea" columns are included to show appreciation for such work. Dr. Yumi Kitamura and Dr. Hirohisa Hioki wrote Chapters 4 and 13, respectively. The remaining chapters were written by Dr. Hajime Kita. In revision for 2018 edition and after, Dr. Hiroyuki Sakai has participated in the author group, and Dr. Donghui Lin has also joined for English edition 2019. The authors hope that this textbook helps you to improve your academic ICT skill set. The content included in this book is selected based on the reference course plan discussed in the course development team for informatics at the Institute for Liberal Arts and Sciences. In writing this textbook, we obtained advice and suggestions from staffs of the Network Section, Information Infrastructure Division, Department of Planning and Information Management Department, Kyoto University on Chapters 2 and 3, from Mr. Sosuke Suzuki, NTT Communications Corporation also on Chapter 3, Rumi Haratake, Machiko Sakurai and Taku Sakamoto of the User Support Division, Kyoto University Library on Chapter 4. Dr. Masako Okamoto of Center for the Promotion of Excellence in Higher Education, Kyoto University helped us in revision of 2018 Japanese Edition. The authors would like to express their sincere gratitude to the people who supported them

GABA-containing sympathetic preganglionic neurons in rat thoracic spinal cord send their axons to the superior cervical ganglion.

GABA-containing fibers have been observed in the rat superior cervical ganglion (SCG) and, to a lesser extent, in the stellate ganglion (STG). The aim of present study is to clarify the source of these fibers. No cell body showed mRNAs for glutamic acid decarboxylases (GADs) or immunoreactivity for GAD of 67 kDa (GAD67) in the cervical sympathetic chain. Thus, GABA-containing fibers in the ganglia are suggested to be of extraganglionic origin. Since GAD67-immunoreactive fibers were found not in the dorsal roots or ganglia, but in the ventral roots, GABA-containing fibers in the sympathetic ganglia were considered to originate from the spinal cord. Furthermore, almost all GAD67-immunoreactive fibers in the sympathetic ganglia showed immunoreactivity for vesicular acetylcholine transporter, suggesting that GABA was utilized by some cholinergic preganglionic neurons. This was confirmed by the following results: 1) after injection of Sindbis/palGFP virus into the intermediolateral nucleus, some anterogradely labeled fibers in the SCG were immunopositive for GAD67, and 2) after injection of fluorogold into the SCG, some retrogradely labeled neurons in the thoracic spinal cord were positive for GAD67 mRNA. Finally, when the ventral roots of the eighth cervical to the fourth thoracic segments were cut, almost all GAD67- and GABA-immunoreactive fibers disappeared from the ipsilateral SCG and STG, suggesting that the vast majority of GABA-containing fibers in those ganglia were of spinal origin. Thus, the present findings strongly indicate that some sympathetic preganglionic neurons are not only cholinergic, but also GABAegi

Convenient modular method for affinity labeling (MoAL method) based on a catalytic amidation

金沢大学医薬保健研究域薬学系A modular methodology for affinity labeling, in which three essential elements generally constituting affinity probes are prepared separately as individual molecules, has been developed based on a catalytic amidation. © 2009 The Royal Society of Chemistry

Direct fast heating efficiency of a counter-imploded core plasma employing a laser for fast ignition experiments (LFEX)

Fast heating efficiency when a pre-imploded core is directly heated with an ultraintense laser (heating laser) was investigated. \u27Direct heating\u27 means that a heating laser hits a pre-imploded core without applying either a laser guiding cone or an external field. The efficiency, η, is defined as the increase in the internal core energy divided by the energy of the heating laser. Six beams (output of 1.6 kJ) from the GEKKO XII (GXII) green laser system at the Institute of Laser Engineering (ILE), Osaka University were applied to implode a spherical deuterated polystyrene (CD) shell target to form a dense core. The DD-reacted protons and the core x-ray emissions showed a core density of 2.8 ± 0.7 g cm−3, or 2.6 times the solid density. Furthermore, DD-reacted thermal neutrons were utilized to estimate the core temperature between 600 and 750 eV. Thereafter, the core was directly heated by a laser for fast-ignition experiments (LFEX, an extremely energetic ultrashort pulse laser) at ILE with its axis lying along or perpendicular to the GXII bundle axis, respectively. The former and latter laser configurations were termed \u27axial\u27 and \u27transverse modes\u27, respectively. The η was estimated from three independent methods: (1) the core x-ray emission, (2) the thermal neutron yield, and (3) the runaway hot electron spectra. For the axial mode, 0.8%< η <2.1% at low power (low LFEX energy) and 0.4%< η <2.5% at high power (high LFEX energy). For the transverse mode, 2.6%< η <7% at low power and 1.5%< η <7.7% at high power. Their efficiencies were compared with that in the uniform implosion mode using 12 GXII beams, 6% < η <12%, which appeared near to the η for the transverse mode, except that the error bar is very large

Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

Background:Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ), which is produced from amyloid precursor protein by β- and γ-secretase (presenilin complex)-mediated sequential cleavage. Induced pluripotent stem (iPS) cells potentially provide an opportunity to generate a human cell-based model of AD that would be crucial for drug discovery as well as for investigating mechanisms of the disease. Methodology/Principal Findings:We differentiated human iPS (hiPS) cells into neuronal cells expressing the forebrain marker, Foxg1, and the neocortical markers, Cux1, Satb2, Ctip2, and Tbr1. The iPS cell-derived neuronal cells also expressed amyloid precursor protein, β-secretase, and γ-secretase components, and were capable of secreting Aβ into the conditioned media. Aβ production was inhibited by β-secretase inhibitor, γ-secretase inhibitor (GSI), and an NSAID; however, there were different susceptibilities to all three drugs between early and late differentiation stages. At the early differentiation stage, GSI treatment caused a fast increase at lower dose (Aβ surge) and drastic decline of Aβ production. Conclusions/Significance:These results indicate that the hiPS cell-derived neuronal cells express functional β- and γ-secretases involved in Aβ production; however, anti-Aβ drug screening using these hiPS cell-derived neuronal cells requires sufficient neuronal differentiation

Vesicular Glutamate Transporter 3 ト Preprotachykinin B オ サンセイスル ダイノウ シンヒシツ カイザイ シンケイ サイボウ ガ コウセイスル トクイテキ シンケイ カイロモウ

京都大学0048新制・論文博士博士(医学)乙第12263号論医博第1965号新制||医||971(附属図書館)UT51-2008-N527京都大学大学院医学研究科脳統御医科学系専攻(主査)教授 渡邉 大, 教授 河野 憲二, 教授 林 拓二学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDA