On Level p

We give a simple formula for the Fourier coefficients of some degree-two Siegel cusp form with level p

miRNA-based rapid differentiation of purified neurons from hPSCs advancestowards quick screening for neuronal disease phenotypes in vitro

Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs). Currently, methods involving the transient expression of one or a couple of transcription factors have been established as techniques for inducing neuronal differentiation in a rapid, single step. It has also been reported that microRNAs can function as reprogramming effectors for directly reprogramming human dermal fibroblasts to neurons. In this study, we tested the effect of adding neuronal microRNAs, miRNA-9/9*, and miR-124 (miR-9/9*-124), for the neuronal induction method of hPSCs using Tet-On-driven expression of the Neurogenin2 gene

Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model

SummaryBipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) cyclic activity levels in αCaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes. We report that gene-expression patterns in the hippocampal dentate gyrus could retrospectively predict whether the mice were in a state of high or low locomotor activity (LA). Expression of a subset of circadian genes, as well as levels of cAMP and pCREB, possible upstream regulators of circadian genes, were correlated with LA states, suggesting that the intrinsic molecular circuitry changes concomitant with infradian oscillatory LA. Taken together, these findings shed light onto the molecular basis of how irregular biological rhythms and behavior are controlled by the brain

Magnetic Instability of Pr3Ru4Sn13

We report on the quantum criticality of Pr$_3$Ru$_4$Sn$_{13}$ revealed by our new material research. Pr$_3$Ru$_4$Sn$_{13}$ has been synthesized by flux growth and characterized by single X-ray, powder X-ray, and powder neutron diffraction measurements. The compound adopts a Yb$_3$Rh$_4$Sn$_{13}$-type structure with a cubic Pm$\bar{3}$n. From the magnetization at 1 T, the effective magnetic moment was estimated to be 3.58 $\mu _B$ per Pr$^{3+}$, suggesting that the magnetism is mainly contributed by Pr$^{3+}$ ions. The specific heat and magnetization show an anomaly at $T_{N} = 7.5$ ~ K owing to the phase transition. The muon spin rotation and relaxation ($\mu$SR) time spectra exhibit clear oscillations below $T_N$. This suggests that the phase is magnetically ordered. The volume fraction of the magnetic phase estimated from the initial asymmetry is around ten percent. In addition, spin fluctuations were observed at low temperatures. These results provide microscopic evidence that the material is closest to the antiferromagnetically quantum critical point with a partial order among Pr$_3$$T_4$Sn$_{13}$ ($T=$ Co, Ru, Rh).Comment: 14 pages, 4 figures, accepted for publication in J. Phys. Soc. Jp