Treatment Outcomes of Pulmonary Metastases from Head and Neck Squamous Cell Carcinoma

Although the lung is the most common site of distant metastases from head and neck squamous cell carcinoma (HNSCC), the number of reports about the effects of pulmonary metastasectomy for the treatment of lung metastasis from HNSCC is limited. Metachronous pulmonary metastases were detected in 45 HNSCC patients at Kumamoto University Hospital from 1998 to 2018. Twenty-two patients underwent an operative resection (Ope group) and 23 underwent chemotherapy (Chemo group). The 3-year overall survival (OS) rate and median OS were evaluated. The effects of adjuvant chemotherapy after pulmonary metastasectomy and of new drugs (cetuximab and nivolumab), in the chemo group were also assessed. The 3-year OS rates and median OS were: Ope, 66.1% and 31.5 months; Chemo, 39.7% and 18 months, respectively. In the Ope group, addi-tional recurrences were significantly fewer in the patients who underwent adjuvant chemotherapy post-surgery versus the patients who underwent surgery alone (p = 0.013). In the Chemo group, the 3-year OS rate of the patients who received new drugs was significantly better than that of the patients who did not (p = 0.021). Adjuvant chemotherapy after pulmonary metastasectomy may be a preferable treatment option for preventing recurrences. Cetuximab and nivolumab have a potential to improve OS

Survivable virtual network mapping with content connectivity against multiple link failures in optical metro networks

Network connectivity, i.e., the reachability of any network node from all other nodes, is often considered as the default network survivability metric against failures. However, in the case of a large-scale disaster disconnecting multiple network components, network connectivity may not be achievable. On the other hand, with the shifting service paradigm towards the cloud in today's networks, most services can still be provided as long as at least a content replica is available in all disconnected network partitions. As a result, the concept of content connectivity has been introduced as a new network survivability metric under a large-scale disaster. Content connectivity is defined as the reachability of content from every node in a network under a specific failure scenario. In this work, we investigate how to ensure content connectivity in optical metro networks. We derive necessary and sufficient conditions and develop what we believe to be a novel mathematical formulation to map a virtual network over a physical network such that content connectivity for the virtual network is ensured against multiple link failures in the physical network. In our numerical results, obtained under various network settings, we compare the performance of mapping with content connectivity and network connectivity and show that mapping with content connectivity can guarantee higher survivability, lower network bandwidth utilization, and significant improvement of service availability