Casimir scaling hypothesis on the nonperturbative force in QCD vs. dual superconducting scenario of confinement

We discuss the Casimir scaling hypothesis on the nonperturbative force in terms of the dual superconducting picture of the QCD vacuum by calculating the string tensions of flux tubes associated with static charges in various SU(3) representations in the dual Ginzburg-Landau (DGL) theory.Comment: 4 pages, 1 figure, Talk given at XVI International Conference on Particles and Nuclei (PaNic02), Osaka, Japan, Sep.30 - Oct.4, 200

String representation of the dual Ginzburg-Landau theory beyond the London limit

The effective string action of the color-electric flux tube in the dual Ginzburg-Landau (DGL) theory is studied by performing a path-integral analysis by taking into account the finite thickness of the flux tube. A modified Yukawa interaction appears as a boundary contribution and is reduced into the ordinary Yukawa interaction in the London Limit.Comment: 3 Pages, Talk given at 5th International Conference on Quark Confinement and the Hadron Spectrum, Gargnano, Brescia, Italy, 10-14 Sep 200

Effective string action for the U(1)xU(1) dual Ginzburg-Landau theory beyond the London limit

The effective string action of the color-electric flux tube in the U(1) x U(1) dual Ginzburg-Landau (DGL) theory is studied by performing a path-integral analysis by taking into accountthe finite thickness of the flux tube. The DGL theory, corresponding to the low-energy effective theory of Abelian-projected SU(3) gluodynamics, can be expressed as s [U(1)]^{3} dual Abelian Higgs (DAH) model with a certain constraint in the Weyl symmetric formulation. This formulation allows us to adopt quite similar path-integral techniques as in the U(1) DAH model, and therefore, the resulting effective string action in the U(1) x U(1) DGL theory has also quite a similar structure except the number of color degrees of freedom. A modified Yukawa interaction appears as a boundary contribution, which is completely due to the finite thickness of the flux tube, and is reduced into the ordinary Yukawa interaction in the deep type-II (London) Limit.Comment: 17 pages, 1 eps figure, The version accepted for publication in Nucl. Phys.

Towards the String representation of the dual Abelian Higgs model beyond the London limit

We perform a path-integral analysis of the string representation of the dual Abelian Higgs (DAH) model beyond the London limit, where the string describing the vortex of a flux tube has a finite thickness. We show that besides an additional vortex core contribution to the string tension, a modified Yukawa interaction appears as a boundary contribution in the type-II dual superconducting vacuum. In the London limit, the modified Yukawa interaction is reduced to the Yukawa one.Comment: 13 pages, JHEP3.cls is used, no figures. The version accepted for publication in JHE

Weyl Invariant Formulation of Flux-Tube Solution in the Dual Ginzburg-Landau Theory

The flux-tube solution in the dual Ginzburg-Landau (DGL) theory in the Bogomol'nyi limit is studied by using the manifestly Weyl invariant form of the DGL Lagrangian. The dual gauge symmetry is extended to $[U(1)]_m^3$, and accordingly, there appear three different types of the flux-tube. The string tension for each flux-tube is calculated analytically and is found to be the same owing to the Weyl symmetry. It is suggested that the flux-tube can be treated in quite a similar way with the Abrikosov-Nielsen-Olesen vortex in the U(1) Abelian Higgs theory except for various types of flux-tube.Comment: 12 pages, revtex, no figur

Tongue Cancer Cell-Derived CCL20 Induced by Interaction With Macrophages Promotes CD163 Expression on Macrophages

BackgroundCD163-positive macrophages contribute to the aggressiveness of oral squamous cell carcinoma. We showed in a previous report that CD163-positive macrophages infiltrated not only to the cancer nest but also to its surrounding epithelium, depending on the presence of stromal invasion in tongue carcinogenesis. However, the role of intraepithelial macrophages in tongue carcinogenesis remains unclear. In this study, we assessed the biological behavior of intraepithelial macrophages on their interaction with cancer cells.Materials and MethodsWe established the indirect coculture system (intraepithelial neoplasia model) and direct coculture system (invasive cancer model) of human monocytic leukemia cell line THP-1-derived CD163-positive macrophages with SCC25, a tongue squamous cell carcinoma (TSCC) cell line. Conditioned media (CM) harvested from these systems were analyzed using cytokine array and enzyme-linked immunosorbent assay and extracted a specific upregulated cytokine in CM from the direct coculture system (direct CM). The correlation of both this cytokine and its receptor with various clinicopathological factors were evaluated based on immunohistochemistry using clinical samples from 59 patients with TSCC. Moreover, the effect of this cytokine in direct CM on the phenotypic alterations of THP-1 was confirmed by real-time polymerase chain reaction, western blotting, immunofluorescence, and transwell migration assay.ResultsIt was shown that CCL20 was induced in the direct CM specifically. Interestingly, CCL20 was produced primarily in SCC25. The expression level of CCR6, which is a sole receptor of CCL20, was higher than the expression level of SCC25. Our immunohistochemical investigation showed that CCL20 and CCR6 expression was associated with lymphatic vessel invasion and the number of CD163-positive macrophages. Recombinant human CCL20 induced the CD163 expression and promoted migration of THP-1. We also confirmed that a neutralizing anti-CCL20 antibody blocked the induction of CD163 expression by direct CM in THP-1. Moreover, ERK1/2 phosphorylation was associated with the CCL20-driven induction of CD163 expression in THP-1.ConclusionsTongue cancer cell-derived CCL20 that was induced by interaction with macrophages promotes CD163 expression on macrophages

Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models

Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment and are considered potential targets for cancer immunotherapy. To examine the antitumor effects of agents targeting human TAMs in vivo, we here established preclinical tumor xenograft models based on immunodeficient mice that express multiple human cytokines and have been reconstituted with a human immune system by transplantation of human CD34$^{+}$ hematopoietic stem and progenitor cells (HIS-MITRG mice). HIS-MITRG mice supported the growth of both human cell line (Raji)- and patient-derived B cell lymphoma as well as the infiltration of human macrophages into their tumors. We examined the potential antitumor action of an antibody to human SIRPα (SE12C3) that inhibits the interaction of CD47 on tumor cells with SIRPα on human macrophages and thereby promotes Fcγ receptor-mediated phagocytosis of the former cells by the latter. Treatment with the combination of rituximab (antibody to human CD20) and SE12C3 inhibited Raji tumor growth in HIS-MITRG mice to a markedly greater extent than did rituximab monotherapy. This enhanced antitumor effect was dependent on human macrophages and attributable to enhanced rituximab-dependent phagocytosis of lymphoma cells by human macrophages. Treatment with rituximab and SE12C3 also induced reprogramming of human TAMs toward a proinflammatory phenotype. Furthermore, the combination treatment essentially prevented the growth of patient-derived diffuse large B cell lymphoma in HIS-MITRG mice. Our findings thus support the study of HIS-MITRG mice as a model for the preclinical evaluation in vivo of potential therapeutics, such as antibodies to human SIRPα, that target human TAMs