Improved sensitivity of interferometric gravitational wave detectors to ultralight vector dark matter from the finite light-traveling time

Recently several studies have pointed out that gravitational-wave detectors are sensitive to ultralight vector dark matter and can improve the current best constraints given by the Equivalence Principle tests. While a gravitational-wave detector is a highly precise measuring tool of the length difference of its arms, its sensitivity is limited because the displacements of its test mass mirrors caused by vector dark matter are almost common. In this Letter we point out that the sensitivity is significantly improved if the effect of finite light-traveling time in the detector's arms is taken into account. This effect enables advanced LIGO to improve the constraints on the $U(1)_{B-L}$ gauge coupling by an order of magnitude compared with the current best constraints. It also makes the sensitivities of the future gravitational-wave detectors overwhelmingly better than the current ones. The factor by which the constraints are improved due to the new effect depends on the mass of the vector dark matter, and the maximum improvement factors are $470$, $880$, $1600$, $180$ and $1400$ for advanced LIGO, Einstein Telescope, Cosmic Explorer, DECIGO and LISA respectively. Including the new effect, we update the constraints given by the first observing run of advanced LIGO and improve the constraints on the $U(1)_B$ gauge coupling by an order of magnitude compared with the current best constraints.Comment: 6 pages, 3 figure

Ultralight vector dark matter search with auxiliary length channels of gravitational wave detectors

Recently, a considerable amount of attention has been given to the search for ultralight dark matter by measuring the oscillating length changes in the arm cavities of gravitational wave detectors. Although gravitational wave detectors are extremely sensitive for measuring the differential arm length changes, the sensitivity to dark matter is largely attenuated, as the effect of dark matter is mostly common to arm cavity test masses. Here, we propose to use auxiliary length channels, which measure the changes in the power and signal recycling cavity lengths and the differential Michelson interferometer length. The sensitivity to dark matter can be enhanced by exploiting the fact that auxiliary interferometers are more asymmetric than two arm cavities. We show that the sensitivity to $U(1)_{B-L}$ gauge boson dark matter with masses below $7\times 10^{-14}$ eV can be greatly enhanced when our method is applied to a cryogenic gravitational wave detector KAGRA, which employs sapphire test masses and fused silica auxiliary mirrors. We show that KAGRA can probe more than an order of magnitude of unexplored parameter space at masses around $1.5 \times 10^{-14}$ eV, without any modifications to the existing interferometer.Comment: 6 pages, 3 figure

Axion dark matter search using arm cavity transmitted beams of gravitational wave detectors

Axion is a promising candidate for ultralight dark matter which may cause a polarization rotation of laser light. Recently, a new idea of probing the axion dark matter by optical linear cavities used in the arms of gravitational wave detectors has been proposed [Phys. Rev. Lett. 123, 111301 (2019)]. In this article, a realistic scheme of the axion dark matter search with the arm cavity transmission ports is revisited. Since photons detected by the transmission ports travel in the cavity for odd-number of times, the effect of axion dark matter on their phases is not cancelled out and the sensitivity at low-mass range is significantly improved compared to the search using reflection ports. We also take into account the stochastic nature of the axion field and the availability of the two detection ports in the gravitational wave detectors. The sensitivity to the axion-photon coupling, $g_{a\gamma}$, of the ground-based gravitational wave detector, such as Advanced LIGO, with 1-year observation is estimated to be $g_{a\gamma} \sim 3\times10^{-12}$ GeV$^{-1}$ below the axion mass of $10^{-15}$ eV, which improves upon the limit achieved by the CERN Axion Solar Telescope.Comment: 10 pages, 4 figure

エナメル上皮腫におけるHeat Shock Protein27の発現と細胞分化

The expression of HSP27 and some CKs were examined the 40 cases of typical solid/multicystic ameloblastoma using immunohistochemical techniques. In order to examine the relevance of HSP in cell differentiation, we focused on the cytoskeletal expression of CK. CK19 is a marker of typical odontogenic epithelium widely observed in follicular and plexiform types of ameloblastomas. Since staining with CK14 is one of the measures of the differentiation potential of squamous cells and is extensively expressed in both follicular and plexiform types, it implies that squamous differentiation of each type can occur. CK8 was strongly detected in tumor nests in plexiform type but weakly detected in follicular type. It was considered that the expression of HSP27 in plexiform type correlated with the expression of CK8 suggesting that HSP27 might have regulated the expression of CK8.2013博士（歯学）松本歯科大

Pegfilgrastim-Induced Aortitis in a Patient with Small-Cell Lung Cancer Who Received Immunotherapy Combined with Chemotherapy

Introduction: Granulocyte colony-stimulating factor (G-CSF), including pegfilgrastim, increases the peripheral blood leukocyte count and is widely used in clinical practice in combination with cytotoxic chemotherapy. The most frequent side effects of G-CSF are pain and fever; aortitis, in contrast, is a rare and serious side effect. Case Presentation: A 73-year-old man with small-cell lung cancer was treated with a full dose of a combination of carboplatin/etoposide/durvalumab and pegfilgrastim. The patient developed fever and right ear pain 12 days after pegfilgrastim administration and was diagnosed with aortitis by contrast-enhanced computed tomography 5 days later. Because the patient had already been administered the immune checkpoint inhibitor and had a history of hepatitis B, the patient was followed up without corticosteroid administration, and the patient’s symptoms resolved spontaneously. Conclusion: In situations where immunosuppression should be avoided, we believe that follow-up without corticosteroids for G-CSF-induced aortitis is a promising option

Gut and oral microbiota in autoimmune liver disease

The gut microbiota plays a key role in the development of chronic inflammatory liver disease. The gut-liver axis involves inflammatory cells, cytokines, and other molecules that cause liver deterioration. Dysbiosis is important in understanding several liver diseases, especially in relation to the development of autoimmune liver disease. The aim of this review is to provide a current overview of alterations in the gut and oral microbiota associated with autoimmune liver diseases