Implementation of Lenia as a Reaction-Diffusion System

The relationship between reaction-diffusion (RD) systems, characterized by continuous spatiotemporal states, and cellular automata (CA), marked by discrete spatiotemporal states, remains poorly understood. This paper delves into this relationship through an examination of a recently developed CA known as Lenia. We demonstrate that asymptotic Lenia, a variant of Lenia, can be comprehensively described by differential equations, and, unlike the original Lenia, it is independent of time-step ticks. Further, we establish that this formulation is mathematically equivalent to a generalization of the kernel-based Turing model (KT model). Stemming from these insights, we establish that asymptotic Lenia can be replicated by an RD system composed solely of diffusion and spatially local reaction terms, resulting in the simulated asymptotic Lenia based on an RD system, or "RD Lenia". However, our RD Lenia cannot be construed as a chemical system since the reaction term fails to satisfy mass-action kinetics.Comment: Accepted to ALIFE 202

Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction

Drebrin is an actin-binding protein that is preferentially expressed in the brain. It is highly localized in dendritic spines and regulates spine shapes. The embryonic-type (drebrin E) is expressed in the embryonic and early postnatal brain and is replaced by the adult-type (drebrin A) during development. In parallel, NMDA receptor (NMDAR)-dependent long-term depression (LTD) of synaptic transmission, induced by low-frequency stimulation (LFS), is dominant in the immature brain and decreases during development. Here, we report that drebrin regulates NMDAR-dependent and group 1 metabotropic glutamate receptor (mGluR)-dependent LTD induction in the hippocampus. While LFS induced NMDAR-dependent LTD in the developing hippocampus in wild-type (WT) mice, it did not induce LTD in developing drebrin E and A double knockout (DXKO) mice, indicating that drebrin is required for NMDAR-dependent LTD. On the other hand, LFS induced robust LTD dependent on mGluR5, one of group 1 mGluRs, in both developing and adult brains of drebrin A knockout (DAKO) mice, in which drebrin E is expressed throughout development and adulthood. Agonist-induced mGluR-dependent LTD was normal in WT and DXKO mice; however, it was enhanced in DAKO mice. Also, mGluR1, another group 1 mGluR, was involved in agonist-induced mGluR-dependent LTD in DAKO mice. These data suggest that abnormal drebrin E expression in adults promotes group 1 mGluR-dependent LTD induction. Therefore, while drebrin expression is critical for NMDAR-dependent LTD induction, developmental conversion from drebrin E to drebrin A prevents robust group 1 mGluR-dependent LTD

A Sensorimotor Signature of the Transition to Conscious Social Perception: Co-regulation of Active and Passive Touch

It is not yet well understood how we become conscious of the presence of other people as being other subjects in their own right. Developmental and phenomenological approaches are converging on a relational hypothesis: my perception of a “you” is primarily constituted by another subject’s attention being directed toward “me.” This is particularly the case when my body is being physically explored in an intentional manner. We set out to characterize the sensorimotor signature of the transition to being aware of the other by re-analyzing time series of embodied interactions between pairs of adults (recorded during a “perceptual crossing” experiment). Measures of turn-taking and movement synchrony were used to quantify social coordination, and transfer entropy was used to quantify direction of influence. We found that the transition leading to one’s conscious perception of the other’s presence was indeed characterized by a significant increase in one’s passive reception of the other’s tactile stimulations. Unexpectedly, one’s clear experience of such passive touch was consistently followed by a switch to active touching of the other, while the other correspondingly became more passive, which suggests that this intersubjective experience was reciprocally co-regulated by both participants

Pharmacokinetic study of pleural fluid penetration of carbapenem antibiotic agents in chemical pleurisy

SummaryStudy objectivesWe investigated pleural fluid penetration of carbapenem antibiotic agents [imipenem (IPM), panipenem (PAPM), meropenem (MEPM), and biapenem (BIPM)] using an experimental rabbit pleuritis model to clarify the usefulness of the carbapenem agents for the treatment of bacterial pleurisy or pyothorax.Measurements and resultsSerum and pleural fluid specimens were serially collected at 5, 10, 15, 30, 60, 90, 120, 180, 240, 300, and 360min after antibiotic administration for measurement of antibiotic levels. We investigated each agent alone as well as drug solutions containing each agent and a dehydropeptidase-I-specific inhibitor, cilastatin (CS), to remove the influence of dehydropeptidase-I-related hydrolysis. Groups of animals (n=3) received each carbapenem agent with or without CS. Serum and pleural fluid antibiotic levels were measured by high-performance liquid chromatography (HPLC). Because Cmax is not useful for evaluating the antimicrobial effects of carbapenem antibiotic agents due to their dose-dependent antimicrobial activity, we also investigated the AUC, which is correlated with the total drug levels in vivo.Among the drug solutions containing CS, MEPM/CS had the highest pleural fluid AUC0–360 (1594.8±510.3μgmin/ml), and the highest pleural fluid AUC0–360/plasma AUC0–360 ratio (0.79±0.04). BIPM/CS had the highest plasma AUC0–360 (3040.1±1525.9μgmin/ml). In pleural fluid AUC0–360/plasma AUC0–360 ratio MEPM/CS was significantly higher than those for the remaining agents. In pleural fluid AUC0–360 and plasma AUC0–360 there were no significant differences among these mixed solutions.ConclusionsMEPM had the most favorable pleural fluid penetration. Pleural fluid penetration should be examined in infection models and in clinical trials

Parallel Indexing Scheme for Data Intensive Applications

Abstract This paper proposes a parallel indexing scheme of a large amount of data in order to resolve the issues about time limitation. Three kinds of computing-nodes are introduced. These are reception-nodes, representative-nodes, and normal-nodes. A reception-node receives data for insertion. A representative-node receives queries. Normal-nodes retrieve data from indexes. Here, three kinds of indexes are introduced. These are a whole-index, a partial-index, and a reception-index. In a partial-index, data are stored. In a whole-index, partial-indexes are stored as its data. In a reception-index, additional data are stored. The reception-index is moved to a normal-node, and becomes a partial-index. The proposed scheme is also a data distribution scheme for shortening the insertion time. A reception-node accepts additional data even if the index is already built

Polymorphisms in pattern recognition receptors and their relationship to infectious disease susceptibility in pigs

<p>Abstract</p> <p>Background</p> <p>Pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), are censoring receptors for molecules derived from bacteria, viruses, and fungi. The PRR system is a prerequisite for proper responses to pathogens, for example by cytokine production, resulting in pathogen eradication. Many cases of polymorphisms in PRR genes affecting the immune response and disease susceptibility are known in humans and mice.</p> <p>Methods</p> <p>We surveyed polymorphisms in pig genes encoding PRRs and investigated the relationship between some of the detected polymorphisms and molecular function or disease onset.</p> <p>Results</p> <p>Nonsynonymous polymorphisms abounded in pig TLR genes, particularly in the region corresponding to the ectodomains of TLRs expressed on the cell surface. Intracellular TLRs such as TLR3, TLR7, and TLR8, and other intracellular PRRs, such as the peptidoglycan receptor NOD2 and viral RNA receptors RIG-I and MDA5, also possessed nonsynonymous polymorphisms. Several of the polymorphisms influenced molecular functions such as ligand recognition. Polymorphisms in the PRR genes may be related to disease susceptibility in pigs: pigs with a particular allele of <it>TLR2</it> showed an increased tendency to contract pneumonia.</p> <p>Conclusions</p> <p>We propose the possibility of pig breeding aimed at disease resistance by the selection of PRR gene alleles that affect pathogen recognition.</p

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