Image data of figure3B

Asymmetry maps of the patient with near-occlusion of the left ICA (Case 5 in Table 1); Image format is NIfTI. These images were overlayed on the template MRI

Data for figure2

The AI of the parameters in the 35 VOI pairs from the 7 patient

Z-statistics between each subject vs. age-matched NDB reconstructed using the same AC method was performed to yield the Z-score map.

<p>A VOI analysis for the Z-score map was performed using the whole brain VOI (A) for the NS-S or the lesion VOI for the OCI patients (B). The VOI values obtained using the two AC methods were then statistically compared. Y-NDB-Chang’s-AC: NDB reconstructed using Chang’s-AC and composed of younger subjects. O-NDB-Chang’s-AC: NDB reconstructed using Chang’s-AC and composed of older subjects. Y-NDB-CT-AC: NDB reconstructed using CT-AC and composed of younger subjects. O-NDB-CT-AC: NDB reconstructed using CT-AC and composed of older subjects.</p

Increase in extraction of I-123 iomazenil in patients with chronic cerebral ischemia - Fig 2

<p>The AI of the 35 VOI pairs from the 7 patients were plotted in each graph, where the AI of each VOI value was expressed as: </p><p></p> <p></p> <p>Here, in this study, the “affected side” was left in the case 1, 2, 4–7, and right in the case 3 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0190720#pone.0190720.t001" target="_blank">Table 1</a>), and the “unaffected side” was contralateral to the “affected side”.</p> <p>Significant correlations were found between (A) the AI of IMZ-EF and the AI of OEF, (B) the AI of approx IMZ-EF and the AI of OEF, (C) the AI of IMZ-K1 and AI of CMRO₂, (D) the AI of early-SPECT and the AI of CMRO₂, (E) the AI of IMZ-K1 and the AI of CBF, (F) the AI of early-SPECT and the AI of CBF, (G) the AI of IMZ-PS and the AI of O₂-PS, (H) the AI of IMZ-K1 and the CMRO2, and (I) the AI of IMZ-EF and the OEF.</p

PET and SPECT images

PET and SPECT image data (NIfTI) of all the cases; early-SPECT: SPECT count image in the early phase scan, IMZ-K1: IMZ K1 parametric image (voxel value is 10000 times K1(ml/min)), PET-CBF: CBF parametric image (voxel value is 100 times CBF(ml/100ml/min), PET-CMRO2: CMRO2 parametric image (voxel value is 1000 times CMRO2(ml/100ml/min)), PET-OEF: OEF parametric image (voxel value is 100 times OEF(%)

Comparison of Z-score for OCI lesions between the two AC methods.

<p>Comparison of Z-score for OCI lesions between the two AC methods.</p

CT-Based Attenuation Correction in Brain SPECT/CT Can Improve the Lesion Detectability of Voxel-Based Statistical Analyses - Fig 5

<p>A) (a) A CT attenuation coefficient (HU) map of each subject was normalized to the transaxial template oriented along the orbitomeatal line and smoothed using an isotropic Gaussian kernel (FWHM, 12 mm). (c) The positive attenuation coefficients were summed in each slice using the brain mask ROI (b) created by masking the CT mu map (see text). (d) The ISCV of (c) for the NDB (combination of the Y-NDB and the O-NDB) was calculated. (e) The difference between the ISCV map of NDB-Chang’s-AC (e) and the ISCV map of NDB-CT-AC (f) was used to create a map of the difference in ISCV (g). The mean of (g) in each transaxial brain mask ROI (h) was then evaluated. B) The ISCV of the slice-based summation of positive attenuation coefficients (HU) using CT (d) and the mean difference in the ISCV-NDB between the two AC methods (i) for each ROI is plotted. The mean ISCV-NDB-Chang’s-AC was larger than the ISCV-NDB-CT-AC for every ROI. A significant and strong correlation was found between the two parameters.</p

Asymmetry maps of (A) the patient with left ICA occlusion accompanied by old cerebral infarction in the left medial frontal lobe, and (B) the patient with near-occlusion of the left ICA.

<p>Asymmetry maps were created according to the following equation: </p><p></p><p></p> <p>Here A_i was the value of voxel i in the asymmetry map, and P_i or P_j represented the value of the voxel i or j in the parametric image respectively, where j indicated the contralateral location to i. Only positive A_i was displayed by the color scale and overlaid on the corresponding voxels of the symmetric MRI template. Infarcted lesions and areas where the kinetic parameter K1 could not be calculated because of noise or an extraordinarily low count of delayed SPECT images were masked.</p

The ISCV difference (ISCV-NDB-Chang’s-AC–ISCV-NDB-CT-AC) is shown for several brain regions, each of which contains AAL elements.

<p>The ISCV difference (ISCV-NDB-Chang’s-AC–ISCV-NDB-CT-AC) is shown for several brain regions, each of which contains AAL elements.</p

Subject groups and age-based subgroups.

<p>Subject groups and age-based subgroups.</p