Pengaruh Komunikasi Terapeutik Perawat Terhadap Kepuasan Pasien Di Rawat Jalan RSUD Jogja

The Objective of this study is to know influence of nurse therapeutic communication to satisfaction of patients satisfaction in RSUD Yogyakarta. The study was a quantitative research methods such as surveys of descriptive inferential research with cross sectional approach. Number of samples in this research is 285 sample in inpatient and 140 in emergency room. The instrument used a questionnaire. Analysis of data using multiple linear regression. This study show that there is the influence of therapeutic communication nurse to satisfaction of outpatients and Emergency room in RSUD Yogyakarta, and orientation phase is a phase that most influence on patient satisfaction. The most influential to therapeutic communication is termination stage

Cox proportional hazards regression analysis of mortality after airway stenting: Multivariate analysis.

<p>Cox proportional hazards regression analysis of mortality after airway stenting: Multivariate analysis.</p

Airway stenting by metallic stent.

<p>(A) Tracheal compression from advanced esophageal cancer producing marked tracheal compression and critical airway stenosis. (B) Palliation by placement of tracheal Spiral Z stent producing immediate resolution of airway symptoms.</p

Weaning from mechanical ventilation after airway stenting for malignant obstruction.

<p>Weaning from mechanical ventilation after airway stenting for malignant obstruction.</p

Outcomes of airway stenting for malignant obstruction.

<p>Outcomes of airway stenting for malignant obstruction.</p

Causative species of nontuberculous mycobacterial lung disease and comparative investigation on clinical features of <i>Mycobacterium abscessus</i> complex disease: A retrospective analysis for two major hospitals in a subtropical region of Japan

<div><p>Nontuberculous mycobacteria (NTM) lung disease is increasing globally. Although the etiological epidemiology of NTM is different across regions, <i>Mycobacterium avium</i> complex (MAC) is the leading cause of NTM lung disease in most countries, including mainland Japan. Okinawa is located in the southernmost region of Japan and is the only prefecture categorized as a subtropical region in Japan, it is therefore likely the etiological epidemiology of NTM lung disease is different from mainland Japan. From 2009 to 2015, the medical records of patients, with respiratory specimens positive for NTMs, visiting or admitted to two Okinawan hospitals, were retrospectively analyzed. NTM lung disease cases were defined according to the American Thoracic Society criteria and patient epidemiology and clinical information were evaluated. Results indicate four hundred sixteen patients had bacterial cultures positive for NTM. The most common NTM was <i>M</i>. <i>abscessus</i> complex (MABC) (n = 127; 30.5%), followed by <i>M</i>. <i>intracellulare</i> (n = 85; 20.4%). NTM lung disease was diagnosed in 114 patients. Of these cases, MABC was most common (n = 41; 36.0%), followed by <i>M</i>. <i>intracellulare</i> (n = 31; 27.2%). Chronic obstructive pulmonary disease (COPD) and tracheostomy patients were more likely to develop MABC than MAC lung disease. Multivariate analysis showed a probable association between COPD and MABC lung disease. Chest computed tomography (CT) evaluation revealed bronchiectasis, nodules, and consolidation were less frequently observed in MABC patients compared with MAC patients. Our data suggests Okinawa may be one of the few places where MABC is the predominant pathogen causing NTM lung disease and our results add new insight to MABC lung disease, which is not yet well understood.</p></div

Multivariate analysis to determine clinical charecteristics for MABC.

<p>Multivariate analysis to determine clinical charecteristics for MABC.</p

Patient background.

<p>Patient background.</p

NTMs cultured from respiratory samples (N = 416).

<p>NTMs isolated from respiratory specimens were retrospectively analyzed. Others category includes: <i>Mycobacterium kansasii</i> (1.0%), <i>M</i>. <i>szulgai</i> (0.7%), <i>M</i>. <i>xenopi</i> (0.7%), <i>M</i>. <i>peregrium</i> (0.5%), <i>M</i>. <i>scrofulaceum</i> (0.5%), <i>M</i>. <i>simiae</i> (0.2%), and <i>M</i>. <i>terrae</i> (0.2%).</p

Identification of the Genes Chemosensitizing Hepatocellular Carcinoma Cells to Interferon-α/5-Fluorouracil and Their Clinical Significance

<div><p>The incidence of advanced hepatocellular carcinoma (HCC) is increasing worldwide, and its prognosis is extremely poor. Interferon-alpha (IFN-α)/5-fluorouracil (5-FU) therapy is reportedly effective in some HCC patients. In the present study, to improve HCC prognosis, we identified the genes that are sensitizing to these agents. The screening strategy was dependent on the concentration of ribozymes that rendered HepG2 cells resistant to 5-FU by the repeated transfection of ribozymes into the cells. After 10 cycles of transfection, which was initiated by 5,902,875 sequences of a ribozyme library, three genes including protein kinase, adenosine monophosphate (AMP)-activated, gamma 2 non-catalytic subunit (<em>PRKAG2</em>); transforming growth factor-beta receptor II (<em>TGFBR2</em>); and exostosin 1 (<em>EXT1</em>) were identified as 5-FU-sensitizing genes. Adenovirus-mediated transfer of <em>TGFBR2</em> and <em>EXT1</em> enhanced IFN-α/5-FU-induced cytotoxicity as well as 5-FU, although the overexpression of these genes in the absence of IFN-α/5-FU did not induce cell death. This effect was also observed in a tumor xenograft model. The mechanisms of <em>TGFBR2</em> and <em>EXT1</em> include activation of the TGF-β signal and induction of endoplasmic reticulum stress, resulting in apoptosis. In HCC patients treated with IFN-α/5-FU therapy, the <em>PRKAG2</em> mRNA level in HCC tissues was positively correlated with survival period, suggesting that <em>PRKAG2</em> enhances the effect of IFN-α/5-FU and serves as a prognostic marker for IFN-α/5-FU therapy. In conclusion, we identified three genes that chemosensitize the effects of 5-FU and IFN-α/5-FU on HCC cells and demonstrated that <em>PRKAG2</em> mRNA can serve as a prognostic marker for IFN-α/5-FU therapy.</p> </div