A Prospective Study of Long-term Outcomes in Female Patients with Nonalcoholic Steatohepatitis Using Age- and Body Mass Index-matched Cohorts

In patients with nonalcoholic steatohepatitis (NASH), the prevalence of cirrhosis is higher among women than men, and hepatocellular carcinoma (HCC) develops mainly in the cirrhotic stage among women. However, the long-term outcomes in female patients with NASH have not been fully elucidated, and age, gender and BMI were not simultaneously adjusted in previous studies on the prognosis of NASH. To elucidate the outcomes in female patients with NASH, we prospectively compared NASH patients with advanced fibrosis (advanced NASH) with hepatitis C virus-related advanced fibrosis (advanced CHC) patients and NASH patients with mild fibrosis (mild NASH) using study cohorts that were adjusted for body mass index (BMI) in addition to age. The median follow-up period was 92.5 months. Liver-related complication-free survival was significantly reduced in the advanced NASH group compared to the mild NASH group. No liver-related complications developed in the mild NASH group. The overall survival, liver-related complication- and cardiovascular/cerebrovascular disease-free survival were not significantly different between the advanced NASH and CHC groups. Female patients with NASH and advanced fibrosis may have a less favorable prognosis for liver-related complications than the matched cohorts with NASH and mild fibrosis, but may have a similar prognosis to the matched cohorts with CHC

Freak wave in a two-dimensional directional wavefield with bottom topography change. Part 1. Normal incidence wave

In the propagation and evolution of sea waves, previous studies pointed out that the occurrence of the freak wave height is significantly related to the quasi-resonant four-wave interaction in the modulated waves. From numerical--experimental study over an uneven bottom, the nonlinear effect caused by the bathymetry change also contributes to the occurrence of extreme events in unidirectional waves. To comprehensively analyse the two-dimensional wavefield, this study develops an evolution model for a directional random wavefield based on the depth-modified nonlinear Schrödinger equation, which considers the nonlinear resonant interactions and the wave shoaling the shallow water. Through Monte Carlo simulation, we discuss the directional effect on the four-wave interaction in the wave train and the maximum wave height distribution from deep to shallow water with a slow varying slope. The numerical result indicates that the directional spreading has a dispersion effect on the freak wave height. In a shallow-water environment, this effect becomes weak, and the bottom topography change is the main influencing factor in the wave evolution

THE COMPARISON TO THE CHARACTERISTICS OF THREE-DIMENSIONAL JOINT KINETICS BETWEEN SINGLE LEG AND DOUBLE LEG REBOUND JUMP

The purpose of this study was to clarify the differences between the SRJ and DRJ in terms of three-dimensional joint kinetics for the takeoff leg. Twenty male track and field athletes were performed repeated rebound jump with single leg (SRJ) and double leg (DRJ). Kinematics and kinetics data were recorded using Vicon T20 system (250 Hz) and force platforms (1000 Hz). When comparing a SRJ to a DRJ, the characteristics of the former are as follows: 1) the jump height by a single leg is significantly higher because of the larger hip joint work around the extension-flexion, especially on the abduction-adduction axes; 2) the hip extension and abduction torque is larger; and 3) in the SRJ, the hip abduction torque is larger than the hip extension torque. Therefore, the joint kinetics of the SRJ is characterized by the large hip abduction torque, in addition to the large hip extension torque

Bariatric Surgery on Type 2 Diabetes Mellitus Patients in Japan

Article信州医学雑誌 59(4): 273-279(2011)departmental bulletin pape

Organic Matter Clogging Results in Undeveloped Hardpan and Soil Mineral Leakage in the Rice Terraces in the Philippine Cordilleras

Rice terraces in Cordillera, Philippines, a world cultural heritage site, are threatened by the risk of collapse. It is crucial to manage these rice terraces for their conservation, while simultaneously practicing traditional farming. We examined the soil environment and investigated its effects on rice terrace conservation, by focusing on the hardpan condition; infiltration process, which is related to the collapse of rice terraces; and soil nutrition conditions in these sites. Field survey and soil analysis revealed that in areas where the hardpan was not sufficiently developed and water infiltration was effectively suppressed, organic matter content was significantly high, suggesting organic matter clogging. In these rice terraces, the amounts of P, K, Ca, and Mn were significantly low, showing the mineral leaching under reductive soil conditions. Therefore, hardpan formation, rather than organic matter clogging, is essential for the suppression of infiltration and prevention of potential terrace collapse. Because hardpan formation or organic matter clogging cannot be identified from the surface of flooded rice paddies, it is difficult to identify the influencing factor. Thus, we suggest that the hard soil layer should be checked before the planting season and drainage is allowed after the cropping season in the rainy season

I Institutional Research for Internal Quality Assurance on Educational Program from the Standpoint of Educational Research

On the occasion of the third cycle of the institutional certified evaluation and accreditation, this research examines internal quality assurance for improving educational study with properly selected evaluation objectives and focuses on internal quality assurance in the educational program or curriculum for undergraduate students rather than systematic quality assurance of the entire university. The study concludes with five features suitable for institutional research (IR): 1) strengthening the evaluation function of the educational program; 2) consistently assessing the qualities and abilities as a school corporation; 3) advanced evaluation making full use of expertise in statistical analysis; 4) developing systems to support the students own identity; and 5) collaboration between faculty and teachers across departments. As an IR project, the study also demonstrates in reviewing and improving the curriculum through the decision tree analysis, collaboration with faculty and the education development support center