Effects of Initial Graft Tension during Anterior Talofibular Ligament Reconstruction on Ankle Kinematics, Laxity, and In-situ Forces of the Reconstructed Graft

前距腓靭帯は，足関節の安定性に関わる重要な靱帯である．前距腓靱帯の損傷後に慢性的な足関節の不安定性が残存した場合，前距腓靱帯再建手術が必要となるが，その際に再建靭帯にかける適切な張力について研究した報告はなかった．本論文では，再建靭帯にかける張力の違いが，足関節のキネマティクス，制動性，術後の靱帯張力に及ぼす影響と適切な再建靭帯初期固定張力を明らかにした

Comparison of glucose monitoring between Freestyle Libre Pro and iPro2 in patients with diabetes mellitus

Aims/Introduction: Flash and continuous glucose monitoring systems are becomingprevalent in clinical practice. We directly compared a flash glucose monitoring system(FreeStyle Libre Pro [FSL-Pro]) with a continuous glucose monitoring system (iPro2) inpatients with diabetes mellitus.Materials and Methods: Glucose concentrations were simultaneously measured usingthe FSL-Pro, iPro2 and self-monitoring blood glucose in 10 patients with diabetes mellitus,and agreement among them was assessed.Results: Parkes error grid analysis showed that the 92.9 and 7.1% of glucose valuesmeasured using the FSL-Pro fell into areas A and B, respectively, and that 96.3, 2.8 and0.9% of those determined using iPro2 fell into areas A, B and C, respectively. The medianabsolute relative differences compared with self-monitoring blood glucose were 8.1%(3.9–12.7%) and 5.0% (2.6–9.1%) for the FSL-Pro and iPro2, respectively. Analysis of 5,555paired values showed a close correlation between FSL-Pro and iPro2 glucose values(q = 0.96, P < 0.01). Notably, 65.3% of all glucose values were lower for the FSL-Pro thanthe iPro2. Median glucose values also decreased by 3.3% for the FSL-Pro compared withthe iPro2 (177.0 [133.0–228.0] vs 183.0 [145.0–230.0] mg/dL, P < 0.01). The difference inglucose values between the two systems was more pronounced in hypoglycemia. Themedian absolute relative difference between FSL-Pro and iPro2 during hypoglycemia wasmuch larger than that during euglycemia and hyperglycemia.Conclusions: Both the FSL-Pro and iPro2 systems are clinically acceptable, but glucosevalues tended to be lower when measured using the FSL-Pro than the iPro2. Agreementwas not close between these systems during hypoglycemia

The Possibility of Suppression of Increased Postprandial Blood Glucose Levels by Gamma-Polyglutamic Acid-Rich Natto in the Early Phase after Eating: A Randomized Crossover Pilot Study

The natto containing high levels of gamma-polyglutamic acid (&gamma;-PGA) was recently developed. We investigated the effect of &gamma;-PGA-rich natto consumption on postprandial glycemic excursion in humans. A randomized crossover meal test study was performed on healthy volunteers aged 20&ndash;64 years using the following test meals: (1) white rice (WR), (2) low-&gamma;-PGA natto meal (WR + low-&gamma;-PGA natto), and (3) high-&gamma;-PGA natto meal (WR + high-&gamma;-PGA natto). Blood samples were obtained at each visit before and for 120 min after loading. The incremental area under the curve (IAUC) of blood glucose and insulin levels was calculated and compared among the test meals. The blood glucose&rsquo;s IAUC at 0&ndash;120 min, the primary endpoint, was 20.1% and 15.4% lower for the high- and low-&gamma;-PGA natto meal than for the WR, with a significant difference only between the high-&gamma;-PGA natto meal and WR (p &lt; 0.05). The blood glucose&rsquo;s IAUC at 0&ndash;15, 0&ndash;30, and 0&ndash;45 min was lower for the high-&gamma;-PGA natto meal than for the low-&gamma;-PGA natto meal (all p &lt; 0.05). The possibility that high-&gamma;-PGA natto might suppress blood glucose elevations in the early phase after eating is indicated