Relationship between silent brain infarction and chronic kidney disease

Background. The presence of silent brain infarction (SBI) increases the risk of symptomatic stroke and dementia. The association between SBI and chronic kidney disease (CKD) has not been clarified. Moreover, little is known about what factors are related to SBI in CKD patients and whether the prevalence of SBI differs in CKD stage or cause of CKD

The Transcriptome of Human Epicardial, Mediastinal and Subcutaneous Adipose Tissues in Men with Coronary Artery Disease

The biological functions of epicardial adipose tissue (EAT) remain largely unknown. However, the proximity of EAT to the coronary arteries suggests a role in the pathogenesis of coronary artery disease (CAD). The objectives of this study were to identify genes differentially regulated among three adipose tissues, namely EAT, mediastinal (MAT) and subcutaneous (SAT) and to study their possible relationships with the development of cardiovascular diseases.Samples were collected from subjects undergoing coronary artery bypass grafting surgeries. Gene expression was evaluated in the three adipose depots of six men using the Illumina® HumanWG-6 v3.0 expression BeadChips. Twenty-three and 73 genes were differentially up-regulated in EAT compared to MAT and SAT, respectively. Ninety-four genes were down-regulated in EAT compared to SAT. However, none were significantly down-regulated in EAT compared to MAT. More specifically, the expression of the adenosine A1 receptor (ADORA1), involved in myocardial ischemia, was significantly up-regulated in EAT. Levels of the prostaglandin D2 synthase (PTGDS) gene, recently associated with the progression of atherosclerosis, were significantly different in the three pairwise comparisons (EAT>MAT>SAT). The results of ADORA1 and PTGDS were confirmed by quantitative real-time PCR in 25 independent subjects.Overall, the transcriptional profiles of EAT and MAT were similar compared to the SAT. Despite this similarity, two genes involved in cardiovascular diseases, ADORA1 and PTGDS, were differentially up-regulated in EAT. These results provide insights about the biology of EAT and its potential implication in CAD

Association of TNFRSF4 gene polymorphisms with essential hypertension

This is a non-final version of an article published in final form in Mashimo, Yoichi ; Suzuki, Yoichi ; Hatori, Kazuko ; Tabara, Yasuharu ; Miki, Tetsuro ; Tokunaga, Katsushi ; Katsuya, Tomohiro ; Ogihara, Toshio ; Yamada, Michiko ; Takahashi, Norio ; Makita, Yoshio ; Nakayama, Tomohiro ; Soma, Masayoshi ; Hirawa, Nobuhito ; Umemura, Satoshi ; Ohkubo, Takayoshi ; Imai, Yutaka ; Hata, Akira, Association of TNFRSF4 gene polymorphisms with essential hypertension, Journal of Hypertension, 26(5) May 2008, pp. 902-913 autho

A high-salt diet enhances leukocyte adhesion in association with kidney injury in young Dahl salt-sensitive rats

10.1038/hr.2017.31Hypertension Research4011912-92