Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection

In this review, we report that the receptor of mouse hepatitis virus (MHV), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), is an important determinant of mouse susceptibility to MHV infection. This finding was revealed by using mouse strains with two different allelic forms of the MHV receptor, Ceacam1a and Ceacam1b. Although previous studies indicated that susceptibility is determined by a single gene, Ceacam1, our recent work in gene-replaced mice with chimeric Ceacam1 pointed toward the involvement of other host factors (genes) in the susceptibility. Studies on mouse susceptibility to MHV, as well as the factors involved in their susceptibility, are overviewed

Thermomechanical noise of arrayed capacitive accelerometers with 300-NM-gap sensing electrodes

2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 18-22 June 2017.Thermomechanical noise of arrayed capacitive accelerometers with sub-micrometer sensing electrodes was evaluated. The unit accelerometer of the array was 80-μm square, designed as a proportional scale-down of a conventional single-axis accelerometer. Since the size effect shows the capacitance sensitivity per unit volume increases by proportional downsizing, a 10-by-10 array of the one-tenth sized unit accelerometer would have the same sensitivity of a single accelerometer of same occupied area. However, the thermomechanical noise needs to be controlled and reduced by vacuum encapsulation because size reduction causes noise increase. By measuring the electrical impedance at the resonant frequency, the damping coefficient was estimated using electrical equivalent circuit modeling. The estimated thermomechanical noise was reduced below 3 μg√VHZ by encapsulating at 100 Pa, which is low enough for instrumentation applications

A support system for solving problems of two-triangle congruence using "backward chaining"

We developed a system called DELTA that supports the students’ use of backward chaining (BC) to prove the congruence of two triangles. DELTA is designed as an interactive learning environment and supports the use of BC by providing hints and a function to automatically check the proofs inputted by the students. DELTA also has coloring, mark- ing, and highlighting functions to support students’ attempts to prove the congruence of two triangles. We evaluated the efficacy of DELTA with 36 students in the second grade of a junior high school in Japan. We found that (1) the mean number of problems, which the experimental group (EG) completely solved, was statistically higher than that of the control group on the post-test; (2) the EG effectively used the BC strategy to solve problems; and (3) the students’ attempt to use both the forward chaining strategy and the BC strategy led to solving the problems completely

Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses

Presynaptic long-term potentiation (LTP) is thought to play an important role in learning and memory. However, the underlying mechanism remains elusive because of the difficulty of direct recording during LTP. Hippocampal mossy fiber synapses exhibit pronounced LTP of transmitter release after tetanic stimulation and have been used as a model of presynaptic LTP. Here, we induced LTP by optogenetic tools and applied direct presynaptic patch-clamp recordings. The action potential waveform and evoked presynaptic Ca2+ currents remained unchanged after LTP induction. Membrane capacitance measurements suggested higher release probability of synaptic vesicles without changing the number of release-ready vesicles after LTP induction. Synaptic vesicle replenishment was also enhanced. Furthermore, stimulated emission depletion microscopy suggested an increase in the numbers of Munc13-1 and RIM1 molecules within active zones. We propose that dynamic changes in the active zone components may be relevant for the increased fusion competence and synaptic vesicle replenishment during LTP

Large Magnetic-Field-Induced Strains in Sintered Chromium Tellurides

Sintered samples of Cr3Te4 and Cr2Te3 are found to show large strains accompanied by large volume changes under a magnetic field. In Cr3Te4, volume increases of deltaV/V = 500-1170 ppm by applying a magnetic field of 9 T are observed over the entire temperature range below 350 K. At room temperature, the deltaV/V value exceeds 1000 ppm, which is considerably larger than the maximum values reported for Cr-based magnets thus far and is comparable to the room-temperature value of forced-volume magnetostriction in invar alloys. Cr2Te3 show a large deltaV/V of 680 ppm when applying a magnetic field of 9 T at 200 K. Both samples display particularly large volume increases around the Curie temperature, where they also show negative thermal expansion due to microstructural effects, suggesting that the cooperation between anisotropic lattice deformation associated with the magnetic ordering and microstructural effects is essential for the manifestation of the large magnetic-field-induced volume changes.Comment: 6 pages, 6 figure