Sex hormones alter the effect of aspirin on bleeding

Background: Interaction of aspirin and sex hormones was investigated through bleeding time.Methods: Bleeding time in 32 males and 105 unmarried females with previous 6 normal menstrual cycles and all aged between 18 to 21 years was found by Duke’s method before and after 2 hours of aspirin administration. Phase of menstrual cycle of each female was determined by present menstrual history.Results: Bleeding time in 32 male was 69.33± 4.94 seconds and in 105 female was 73.03±1.89 seconds which were not statistically different (P>0.05).This time was increased to 107.66±4.76 seconds in males and 113.65±3.73 seconds in females after aspirin administration which were statistically different (P0.05) difference after aspirin administration with a greater effect in Follicular phase probably due to estradiol.Conclusion: Males respond to aspirin more as compared to females which is likely the effect of the drug and testosterone interaction. Similarly females in the follicular phase respond to aspirin more as compared to females in the luteal phase which may be a result of interaction of estrogen and aspirin

Variations in Pulmonary Function in Relation with the Menstrual Cycle in Healthy Adult Female

Objective: To compare the respiratory parameters during different menstrual versus luteal phases of the menstrual cycle in healthy adult female. Methodology: This comparative study was conducted in research lab physiology department of Liaquat University of medical and health sciences Jamshoro, from January 2018 July 2018.  Adult healthy non-pregnant females aged between 18 and 24 years were Included. Each participant was advised to visit the Physiology Lab on a particular date for pulmonary function test during menstrual (1-5th day) and luteal (19-22th day) phases, based on their menstrual history. Using the Power lab AD tools 15:HT Computerized Spirometer and parameters recorded on Labtutor software, the participants were made to undertake pulmonary function testing in distinct menstrual cycle stages. All the data was collected via study proforma. Results: Mean age of the cases was 20.03+6.30 years and mean duration of menstrual cycle was 28.62±1.35 days. Mean FVC value was significantly higher in luteal phase (2.57) as compared to menstrual phase (2.50) (p-0.016).  Average FEV1 value was significantly higher in luteal phase (2.61) compared to menstrual phase (2.53) (p-0.009). Average values of PEF and FEV1/FVC were also significantly higher in luteal phase as compared to menstrual phase (p-<0.05). Conclusion: Pulmonary functions as well as respiratory efficiency were significantly improved in luteal phase compared to menstrual phase of menstrual cycle, which were enumerated in this study thus suggesting a possible beneficial role of progesterone in improvement of respiratory parameters. The reason could be the bronchodilator effect of progesterone, its level remains higher during this phase

Concordance between clinical and pathological response assessment after neo-adjuvant chemotherapy in patients with invasive lobular carcinoma

Background: Neo-adjuvant chemotherapy (NAC) is frequently administered in breast carcinoma patients. The clinical response to NAC guides further treatment. The pathological response is not only an independent prognostic factor, but it also guides further treatment and prognosis.Objectives: The aim of our study was to find the degree of concordance between clinical and pathological response assessments after NAC in Invasive lobular Carcinoma (ILC) cases by using World Health Organization (WHO) criteria and different pathological systems, respectively. We also tried to identify any useful parameter of clinical assessment that could better correlate with pathologic assessment and provide a better estimation of residual tumor.Methods: This retrospective study was conducted on 26 ILC tumors diagnosed in 24 patients who were treated with NAC followed by surgical resection between January 2009 and December 2020. Medical records and microscopy glass slides were reviewed for clinical and pathological response assessments, respectively.Results: The pre-treatment tumor area ranged from 1.8-255 cm2 and the mean±SD was 52.2±66.8 cm2. After NAC, complete clinical response was observed in four (15.3%) cases. The clinically assessed mean tumor area significantly reduced from 52.2±66.8 cm2 to 17.2±22.6 cm2 (p-value2) didn’t differ significantly from the clinically assessed mean tumor area (17.2±22.6 cm2) (p-value=0.114). Pathologically, the majority of the cases showed partial response, and a complete pathological response was achieved in only two (7.7%) cases. The concordance rates between clinical assessment by the WHO method and pathological assessment of the breast using the Sataloff method, Miller-Payne (MP) system, Residual Cancer Burden system, and Chevallier method were 26.7%, 15.8%, 9%, and 3.5%, respectively, with insignificant p-values. Percentage reduction in clinical size and percentage reduction in tumor cellularity differed significantly (p-value=0.038).Conclusion: Clinical response assessment provides a less accurate estimation of residual disease, as it shows poor concordance with pathological assessment using different assessment systems/methods

HUMAN RESOURCE MANAGEMENT PRACTICES OF PAKISTANI PUBLIC SECTOR UNIVERSITIES DURING THE PANDEMIC

ABSTRACT   Purpose – Adopting a qualitative approach, this study inquired into Human Resource Management (HRM) practices in relation to job satisfaction. The aim was to develop a better understanding of how and why organizations prioritize performance at the workplace

Adenoid Cystic Cancer

Adenoid cystic carcinoma (ACC) is a rare malignancy arising from the secretory glands, most commonly seen involving the salivary glands. It accounts for approximately 1% of all malignancies of the head and neck region. However, it is the most common tumor of the minor salivary glands and the second most common tumor of the major salivary glands. Overall, it accounts for 10% of all salivary gland tumors. The tumor is typically slow-growing compared to other carcinomas and has a tendency for perineural invasion as well as hematogenous spread to distant organs and is most commonly seen in the elderly. Due to its rarity, limited data is available regarding the predisposing risk factors and the management of patients with advanced disease

Perceived expression of emotion in individuals with a first episode of psychosis from a South Asian background

Aim: To explore perceived expression of emotion in the South Asian context for individuals with a FEP (first episode of psychosis). Method: Semi-structured interviews were conducted with 16 service users (SU) experiencing a first episode of psychosis understand their experience of expression of emotion from their caregivers. Thematic analysis was used to identify the themes that emerged from the interviews. Results: Four main categories were identified: connection and support, understanding and awareness, boundaries and independence, and context and influence. Factors influencing perceived EE such as acceptance, acculturation, warmth and expressions of love, communication and family values have been identified. It also highlights that South Asian caregiving experiences and perception of EE includes warmth and connection as a strength and resource. Discussion and implications for practice: The findings shed light on a culturally specific expression of emotion within the context of FEP and can be considered when working with South Asian communities within EIP services. Findings highlight the impact of navigating and negotiating bicultural identities and generational differences in the expression of emotion in the South Asian context

Print And Electronic Media: Cause Of Depression

Objective: To assess depression in normal people and associate it with print and electronic media of Pakistan. Methodology: The study was descriptive, cross-sectional and conducted from July to November 2011. Three hundred and twenty men and women, with age range of 20-70 years were included in study following informed consent. A structured questionnaire with five items of Yes and No category relating media to depression was used. To assess the severity of depression Zung self –rating depression scale was used. Subjects with score of 80-90 were excluded as this score is of clinical depression. Data analysis was done by SPSS version 13.0. Pearson Chi-square was applied with p<0.01 considered statistically significant. Results: Depression was seen in 55 % of subjects on reading newspaper. Watching television caused depression in 59.7% (p<0001). In 68% subjects daily routine life was disturbed (p<0.01). The highest rate of depression 32.6% was due to watching political news, while 28.3 % were by photographs and visuals of dead bodies and 24.6% by news of terrorism. Prevalence of mildly and moderately depressed individuals was 56.3 % and 15.8% respectively. Conclusion: Reading newspaper and watching television causes depression. The content of news on media in particular leads to depression

Internet of Things as Intimating for Pregnant Women’s Healthcare: An Impending Privacy Issues

Ingeniously, the innovations are taking place in current medical era, where IoT is a key and its related technology plays a dynamic role in pregnant women care taking inside hospital and outside. IoT ensure the effective and efficient care of pregnant women in any environment because intelligent tiny devices like RF-Tags, sensors are attached with pregnant women, and all the activities of pregnant women can be monitored by professional medical staff from anywhere and anytime. The usage of these advanced technologies in pregnant women care environment, absolutely eradicates the pregnancy complications and harmful incidents, but also raises privacy, religious, ethical, legal and social issues. The purpose of this paper is to discuss the usage of IoT in pregnant women healthcare environments and articulates endorsements to promote research then can guarantee that the pregnant women’s privacy is preserved. DOI : http://dx.doi.org/10.11591/telkomnika.v12i6.422