Health-related quality of life in transplant ineligible newly diagnosed multiple myeloma patients treated with either thalidomide or lenalidomide-based regimen until progression: a prospective, open-label, multicenter, randomized, phase 3 study

Data on the impact of long term treatment with immunomodulatory drugs (IMiD) on health-related quality of life (HRQoL) is limited. The HOVON-87/NMSG18 study was a randomized, phase 3 study in newly diagnosed transplant ineligible patients with multiple myeloma, comparing melphalan-prednisolone in combination with thalidomide or lenalidomide, followed by maintenance therapy until progression (MPT-T or MPR-R). The EORTC QLQ-C30 and MY20 questionnaires were completed at baseline, after three and nine induction cycles and six and 12 months of maintenance therapy. Linear mixed models and minimal important differences were used for evaluation. 596 patients participated in HRQoL reporting. Patients reported clinically relevant improvement in global quality of life (QoL), future perspective and role and emotional functioning, and less fatigue and pain in both arms. The latter being of large effect size

Special Report on Global warming of 1.5°C (SR15) - Chapter 5:Sustainable Development, Poverty Eradication and Reducing Inequalities

The Special Report on 1.5°C assesses three main themes: • What would be required to limit warming to 1.5°C (mitigation pathways) • The impacts of 1.5°C of warming, compared to 2ºC and higher • Strengthening the global response to climate change; mitigation and adaptation options The connections between climate change and sustainable development and efforts to eradicate poverty are discussed throughout the report. This chapter takes sustainable development as the starting point and focus for analysis. It considers the broad and multifaceted bi-directional interplay between sustainable development, including its focus on eradicating poverty and reducing inequality in their multidimensional aspects, and climate actions in a 1.5°C warmer world. These fundamental connections are embedded in the Sustainable Development Goals (SDGs). The chapter also examines synergies and trade-offs of adaptation and mitigation options with sustainable development and the SDGs and offers insights into possible pathways, especially climate-resilient development pathways towards a 1.5°C warmer world

A Framework for Semantic Effect Annotation of Business Process Models

A key challenge in devising solutions to a range of problems associated with business process management, such as process life cycle management, compliance management and enterprise process architectures, is the problem of identifying process semantics. The current industry standard business process modelling notation, BPMN, provides little by way of semantic description of the effects of a process (beyond what can be conveyed via the nomenclature of tasks and the decision conditions associated with gateways). This thesis describes the conceptual underpinnings, design and implementation of the Process Semantic Effect Evaluation and Reasoning (ProcessSEER) framework..

IMPLEMENTATION OF GEOGRAPHICAL INFORMATION SYSTEM IN MATERIAL MANAGEMENT AND SUPPLIER SELECTION IN THANE CITY – A CASE STUDY

Material cost contributes 50% to 60% of the total cost of the project. Thus material forms the single largest component of the total cost of the construction activities. Improper selection of suppliers leads to problems related to material price, delivery, communication, quality, availability of materials on time etc. and its adverse effect on the cost of project. Thus, there arises the need of ideal supplier for avoiding time and cost overrun. It can be possible to select the ideal supplier with the help of several supplier selection methods but these traditional methods fails to collect correct information of all the suppliers also it takes more time to collect such information manually. With the help of data base management tools the collection of required supplier data like personal details, cost of materials, quantity, quality, delivery address, location, discount, transportation facility, communication facility etc. would be less or no time consuming. Hence GIS is a powerful set of tools for collecting, storing and quantifying all data of all suppliers and easily screen all suppliers in very short time. This paper suggest that the proposed Arc GIS 10.0 based methodology may replace the manual methods to extract supplier’s information from the available data base , locate location of suppliers and ideal suppliers by developing queries in very short time

STUDY OF END WEIR USING HEC-RAS OF GUNJWANI DAM SPILLWAY

Hydraulic jump is the phenomenon in which the flow changes from superundal flow to subundal flow. The hydraulic jump concept is widely used in any hydraulic structures for energy dissipater at d/s side of the hydraulic structures. Hence Study of hydraulic jump is very important in such field. The HEC-RAS software is used to simulate the flow over ogee spillway. This software is used to determine the location of hydraulic jump and the nature of corresponding water surface profile. Results obtained from the HEC-RAS software are compared with theExperimental results. The Height of Ogee spillway of Gunjawani Dam is 22.76m and width of spillway 27 m.Design Discharge is 1280.03m3/s and Length of stilling basin is 52m.Top width of end weir is 0.6 m, height is 4m and bottom width is 2.6m. This research is useful for checking the feasibility of HEC-RAS software for prediction of location of hydraulic jump and to observe the features of channel flow