2,600 research outputs found
Blackbody excitation of an atom controlled by a tunable cavity
No description supplie
ICP polishing of silicon for high quality optical resonators on a chip
Miniature concave hollows, made by wet etching silicon through a circular
mask, can be used as mirror substrates for building optical micro-cavities on a
chip. In this paper we investigate how ICP polishing improves both shape and
roughness of the mirror substrates. We characterise the evolution of the
surfaces during the ICP polishing using white-light optical profilometry and
atomic force microscopy. A surface roughness of 1 nm is reached, which reduces
to 0.5 nm after coating with a high reflectivity dielectric. With such smooth
mirrors, the optical cavity finesse is now limited by the shape of the
underlying mirror
Clinical validity assessment of a breast cancer risk model combining genetic and clinical information
_Background:_ The extent to which common genetic variation can assist in breast cancer (BCa) risk assessment is unclear. We assessed the addition of risk information from a panel of BCa-associated single nucleotide polymorphisms (SNPs) on risk stratification offered by the Gail Model.

_Methods:_ We selected 7 validated SNPs from the literature and genotyped them among white women in a nested case-control study within the Women’s Health Initiative Clinical Trial. To model SNP risk, previously published odds ratios were combined multiplicatively. To produce a combined clinical/genetic risk, Gail Model risk estimates were multiplied by combined SNP odds ratios. We assessed classification performance using reclassification tables and receiver operating characteristic (ROC) curves. 

_Results:_ The SNP risk score was well calibrated and nearly independent of Gail risk, and the combined predictor was more predictive than either Gail risk or SNP risk alone. In ROC curve analysis, the combined score had an area under the curve (AUC) of 0.594 compared to 0.557 for Gail risk alone. For reclassification with 5-year risk thresholds at 1.5% and 2%, the net reclassification index (NRI) was 0.085 (Z = 4.3, P = 1.0×10^-5^). Focusing on women with Gail 5-year risk of 1.5-2% results in an NRI of 0.195 (Z = 3.8, P = 8.6×10^−5^).

_Conclusions:_ Combining clinical risk factors and validated common genetic risk factors results in improvement in classification of BCa risks in white, postmenopausal women. This may have implications for informing primary prevention and/or screening strategies. Future research should assess the clinical utility of such strategies.

Genome-wide analysis points to roles for extracellular matrix remodeling, the visual cycle, and neuronal development in myopia
Myopia, or nearsightedness, is the most common eye disorder, resulting
primarily from excess elongation of the eye. The etiology of myopia, although
known to be complex, is poorly understood. Here we report the largest ever
genome-wide association study (43,360 participants) on myopia in Europeans. We
performed a survival analysis on age of myopia onset and identified 19
significant associations (p < 5e-8), two of which are replications of earlier
associations with refractive error. These 19 associations in total explain 2.7%
of the variance in myopia age of onset, and point towards a number of different
mechanisms behind the development of myopia. One association is in the gene
PRSS56, which has previously been linked to abnormally small eyes; one is in a
gene that forms part of the extracellular matrix (LAMA2); two are in or near
genes involved in the regeneration of 11-cis-retinal (RGR and RDH5); two are
near genes known to be involved in the growth and guidance of retinal ganglion
cells (ZIC2, SFRP1); and five are in or near genes involved in neuronal
signaling or development. These novel findings point towards multiple genetic
factors involved in the development of myopia and suggest that complex
interactions between extracellular matrix remodeling, neuronal development, and
visual signals from the retina may underlie the development of myopia in
humans
Nonadiabatic transitions in a Stark decelerator
In a Stark decelerator, polar molecules are slowed down and focussed by an
inhomogeneous electric field which switches between two configurations. For the
decelerator to work, it is essential that the molecules follow the changing
electric field adiabatically. When the decelerator switches from one
configuration to the other, the electric field changes in magnitude and
direction, and this can cause molecules to change state. In places where the
field is weak, the rotation of the electric field vector during the switch may
be too rapid for the molecules to maintain their orientation relative to the
field. Molecules that are at these places when the field switches may be lost
from the decelerator as they are transferred into states that are not focussed.
We calculate the probability of nonadiabatic transitions as a function of
position in the periodic decelerator structure and find that for the
decelerated group of molecules the loss is typically small, while for the
un-decelerated group of molecules the loss can be very high. This loss can be
eliminated using a bias field to ensure that the electric field magnitude is
always large enough. We demonstrate our findings by comparing the results of
experiments and simulations for the Stark deceleration of LiH and CaF
molecules. We present a simple method for calculating the transition
probabilities which can easily be applied to other molecules of interest.Comment: 12 pages, 9 figures, minor revisions following referee suggestion
Reconsidering the quantization of electrodynamics with boundary conditions and some measurable consequences
We show that the commonly known conductor boundary conditions
can be realized in two ways which we call 'thick' and 'thin'
conductor. The 'thick' conductor is the commonly known approach and includes a
Neumann condition on the normal component of the electric field
whereas for a 'thin' conductor remains without boundary condition.
Both types describe different physics already on the classical level where a
'thin' conductor allows for an interaction between the normal components of
currents on both sides. On quantum level different forces between a conductor
and a single electron or a neutral atom result. For instance, the
Casimir-Polder force for a 'thin' conductor is by about 13% smaller than for a
'thick' one.Comment: 22 pages, basic statement weakened, conclusions changed, misprints
correcte
A search for varying fundamental constants using Hz-level frequency measurements of cold CH molecules
Many modern theories predict that the fundamental constants depend on time,
position, or the local density of matter. We develop a spectroscopic method for
pulsed beams of cold molecules, and use it to measure the frequencies of
microwave transitions in CH with accuracy down to 3 Hz. By comparing these
frequencies with those measured from sources of CH in the Milky Way, we test
the hypothesis that fundamental constants may differ between the high and low
density environments of the Earth and the interstellar medium. For the fine
structure constant we find \Delta\alpha/\alpha = (0.3 +/- 1.1)*10^{-7}, the
strongest limit to date on such a variation of \alpha. For the
electron-to-proton mass ratio we find \Delta\mu/\mu = (-0.7 +/- 2.2) * 10^{-7}.
We suggest how dedicated astrophysical measurements can improve these
constraints further and can also constrain temporal variation of the constants.Comment: 8 pages, 3 figure
Observation of modified radiative properties of cold atoms in vacuum near a dielectric surface
We have observed a distance-dependent absorption linewidth of cold Rb
atoms close to a dielectric-vacuum interface. This is the first observation of
modified radiative properties in vacuum near a dielectric surface. A cloud of
cold atoms was created using a magneto-optical trap (MOT) and optical molasses
cooling. Evanescent waves (EW) were used to observe the behavior of the atoms
near the surface. We observed an increase of the absorption linewidth with up
to 25% with respect to the free-space value. Approximately half the broadening
can be explained by cavity-quantum electrodynamics (CQED) as an increase of the
natural linewidth and inhomogeneous broadening. The remainder we attribute to
local Stark shifts near the surface. By varying the characteristic EW length we
have observed a distance dependence characteristic for CQED.Comment: 6 pages, 6 figures, some minor revision
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