42 research outputs found
Mechanism, dynamics, and biological existence of multistability in a large class of bursting neurons
Multistability, the coexistence of multiple attractors in a dynamical system,
is explored in bursting nerve cells. A modeling study is performed to show that
a large class of bursting systems, as defined by a shared topology when
represented as dynamical systems, is inherently suited to support
multistability. We derive the bifurcation structure and parametric trends
leading to multistability in these systems. Evidence for the existence of
multirhythmic behavior in neurons of the aquatic mollusc Aplysia californica
that is consistent with our proposed mechanism is presented. Although these
experimental results are preliminary, they indicate that single neurons may be
capable of dynamically storing information for longer time scales than
typically attributed to nonsynaptic mechanisms.Comment: 24 pages, 8 figure
Dynamics of a ferromagnetic domain wall and the Barkhausen effect
We derive an equation of motion for the the dynamics of a ferromagnetic
domain wall driven by an external magnetic field through a disordered medium
and we study the associated depinning transition. The long-range dipolar
interactions set the upper critical dimension to be , so we suggest that
mean-field exponents describe the Barkhausen effect for three-dimensional soft
ferromagnetic materials. We analyze the scaling of the Barkhausen jumps as a
function of the field driving rate and the intensity of the demagnetizing
field, and find results in quantitative agreement with experiments on
crystalline and amorphous soft ferromagnetic alloys.Comment: 4 RevTex pages, 3 ps figures embedde
Dynamics of a ferromagnetic domain wall: avalanches, depinning transition and the Barkhausen effect
We study the dynamics of a ferromagnetic domain wall driven by an external
magnetic field through a disordered medium. The avalanche-like motion of the
domain walls between pinned configurations produces a noise known as the
Barkhausen effect. We discuss experimental results on soft ferromagnetic
materials, with reference to the domain structure and the sample geometry, and
report Barkhausen noise measurements on FeCoB amorphous
alloy. We construct an equation of motion for a flexible domain wall, which
displays a depinning transition as the field is increased. The long-range
dipolar interactions are shown to set the upper critical dimension to ,
which implies that mean-field exponents (with possible logarithmic correction)
are expected to describe the Barkhausen effect. We introduce a mean-field
infinite-range model and show that it is equivalent to a previously introduced
single-degree-of-freedom model, known to reproduce several experimental
results. We numerically simulate the equation in , confirming the
theoretical predictions. We compute the avalanche distributions as a function
of the field driving rate and the intensity of the demagnetizing field. The
scaling exponents change linearly with the driving rate, while the cutoff of
the distribution is determined by the demagnetizing field, in remarkable
agreement with experiments.Comment: 17 RevTeX pages, 19 embedded ps figures + 1 extra figure, submitted
to Phys. Rev.
The Flux-Line Lattice in Superconductors
Magnetic flux can penetrate a type-II superconductor in form of Abrikosov
vortices. These tend to arrange in a triangular flux-line lattice (FLL) which
is more or less perturbed by material inhomogeneities that pin the flux lines,
and in high- supercon- ductors (HTSC's) also by thermal fluctuations. Many
properties of the FLL are well described by the phenomenological
Ginzburg-Landau theory or by the electromagnetic London theory, which treats
the vortex core as a singularity. In Nb alloys and HTSC's the FLL is very soft
mainly because of the large magnetic penetration depth: The shear modulus of
the FLL is thus small and the tilt modulus is dispersive and becomes very small
for short distortion wavelength. This softness of the FLL is enhanced further
by the pronounced anisotropy and layered structure of HTSC's, which strongly
increases the penetration depth for currents along the c-axis of these uniaxial
crystals and may even cause a decoupling of two-dimensional vortex lattices in
the Cu-O layers. Thermal fluctuations and softening may melt the FLL and cause
thermally activated depinning of the flux lines or of the 2D pancake vortices
in the layers. Various phase transitions are predicted for the FLL in layered
HTSC's. The linear and nonlinear magnetic response of HTSC's gives rise to
interesting effects which strongly depend on the geometry of the experiment.Comment: Review paper for Rep.Prog.Phys., 124 narrow pages. The 30 figures do
not exist as postscript file
PSSA-2, a Membrane-Spanning Phosphoprotein of Trypanosoma brucei, Is Required for Efficient Maturation of Infection
The coat of Trypanosoma brucei consists mainly of glycosylphosphatidylinositol-anchored proteins that are present in several million copies and are characteristic of defined stages of the life cycle. While these major components of the coats of bloodstream forms and procyclic (insect midgut) forms are well characterised, very little is known about less abundant stage-regulated surface proteins and their roles in infection and transmission. By creating epitope-tagged versions of procyclic-specific surface antigen 2 (PSSA-2) we demonstrated that it is a membrane-spanning protein that is expressed by several different life cycle stages in tsetse flies, but not by parasites in the mammalian bloodstream. In common with other membrane-spanning proteins in T. brucei, PSSA-2 requires its cytoplasmic domain in order to exit the endoplasmic reticulum. Correct localisation of PSSA-2 requires phosphorylation of a cytoplasmic threonine residue (T305), a modification that depends on the presence of TbMAPK4. Mutation of T305 to alanine (T305A) has no effect on the localisation of the protein in cells that express wild type PSSA-2. In contrast, this protein is largely intracellular when expressed in a null mutant background. A variant with a T305D mutation gives strong surface expression in both the wild type and null mutant, but slows growth of the cells, suggesting that it may function as a dominant negative mutant. The PSSA-2 null mutant exhibits no perceptible phenotype in culture and is fully competent at establishing midgut infections in tsetse, but is defective in colonising the salivary glands and the production of infectious metacyclic forms. Given the protein's structure and the effects of mutation of T305 on proliferation and localisation, we postulate that PSSA-2 might sense and transmit signals that contribute to the parasite's decision to divide, differentiate or migrate
Spin structure at nanojunctions and constrictions
A micromagnetic Green-function approach is used to investigate the effect of nanojunctions, constraints, and other obstacles on spin-dependent conduction. Depending on geometry, the determination of the spin structure involves several types of Bessel functions. A common feature of the Green functions is the involvement of the domain-wall width of the main phase, which can be interpreted as the decay length of the magnetization perturbation away from the junction. This length is typically on the order of 10 nm and independent of the strength of the perturbation. Only the magnitude of the magnetization perturbation depends on the strength of the inhomogenity. A particular feature of the considered structures is that the total spin-dependent scattering cross section, as estimated from the squared magnetization gradient, exhibits a characteristic real-structure dependent maximum as a function of the boundary phase or junction dimensions