SPIDER: Probing the Early Universe with a Suborbital Polarimeter

We evaluate the ability of SPIDER, a balloon-borne polarimeter, to detect a divergence-free polarization pattern ("B-modes") in the Cosmic Microwave Background (CMB). In the inflationary scenario, the amplitude of this signal is proportional to that of the primordial scalar perturbations through the tensor-to-scalar ratio r. We show that the expected level of systematic error in the SPIDER instrument is significantly below the amplitude of an interesting cosmological signal with r=0.03. We present a scanning strategy that enables us to minimize uncertainty in the reconstruction of the Stokes parameters used to characterize the CMB, while accessing a relatively wide range of angular scales. Evaluating the amplitude of the polarized Galactic emission in the SPIDER field, we conclude that the polarized emission from interstellar dust is as bright or brighter than the cosmological signal at all SPIDER frequencies (90 GHz, 150 GHz, and 280 GHz), a situation similar to that found in the "Southern Hole." We show that two ~20-day flights of the SPIDER instrument can constrain the amplitude of the B-mode signal to r<0.03 (99% CL) even when foreground contamination is taken into account. In the absence of foregrounds, the same limit can be reached after one 20-day flight.Comment: 29 pages, 8 figures, 4 tables; v2: matches published version, flight schedule updated, two typos fixed in Table 2, references and minor clarifications added, results unchange

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

BICEP2 / Keck Array XI: Beam Characterization and Temperature-to-Polarization Leakage in the BK15 Dataset

International audiencePrecision measurements of cosmic microwave background (CMB) polarization require extreme control of instrumental systematics. In a companion paper we have presented cosmological constraints from observations with the BICEP2 and Keck Array experiments up to and including the 2015 observing season (BK15), resulting in the deepest CMB polarization maps to date and a statistical sensitivity to the tensor-to-scalar ratio of $\sigma(r) = 0.020$. In this work we characterize the beams and constrain potential systematic contamination from main beam shape mismatch at the three BK15 frequencies (95, 150, and 220 GHz). Far-field maps of 7,360 distinct beam patterns taken from 2010-2015 are used to measure differential beam parameters and predict the contribution of temperature-to-polarization leakage to the BK15 B-mode maps. In the multifrequency, multicomponent likelihood analysis that uses BK15, Planck, and WMAP maps to separate sky components, we find that adding this predicted leakage to simulations induces a bias of $\Delta r = 0.0027 \pm 0.0019$. Future results using higher-quality beam maps and improved techniques to detect such leakage in CMB data will substantially reduce this uncertainty, enabling the levels of systematics control needed for BICEP Array and other experiments that plan to definitively probe large-field inflation

Measurements of Degree-Scale B-mode Polarization with the BICEP/KeckKeck Experiments at South Pole

International audienceThe BICEP and Keck Array experiments are a suite of small-aperture refracting telescopes observing the microwave sky from the South Pole. They target the degree-scale B-mode polarization signal imprinted in the Cosmic Microwave Background (CMB) by primordial gravitational waves. Such a measurement would shed light on the physics of the very early universe. While BICEP2 observed for the first time a B-mode signal at 150 GHz, higher frequencies from the Planck satellite showed that it could be entirely due to the polarized emission from Galactic dust, though uncertainty remained high. Keck Array has been observing the same region of the sky for several years, with an increased detector count, producing the deepest polarized CMB maps to date. New detectors at 95 GHz were installed in 2014, and at 220 GHz in 2015. These observations enable a better constraint of galactic foreground emissions, as presented here. In 2015, BICEP2 was replaced by BICEP3, a 10 times higher throughput telescope observing at 95 GHz, while Keck Array is now focusing on higher frequencies. In the near future, BICEP Array will replace Keck Array, and will allow unprecedented sensitivity to the gravitational wave signal. High resolution observations from the South Pole Telescope (SPT) will also be used to remove the lensing contribution to B-modes