Three-dimensional macroporous silicon photonic crystal with large photonic band gap

Three-dimensional photonic crystals based on macroporous silicon are fabricated by photoelectrochemical etching and subsequent focused-ion-beam drilling. Reflection measurements show a high reflection in the range of the stopgap and indicate the spectral position of the complete photonic band gap. The onset of diffraction which might influence the measurement is discussed

Changes in MEG resting-state networks are related to cognitive decline in type 1 diabetes mellitus patients

OBJECTIVE: Integrity of resting-state functional brain networks (RSNs) is important for proper cognitive functioning. In type 1 diabetes mellitus (T1DM) cognitive decrements are commonly observed, possibly due to alterations in RSNs, which may vary according to microvascular complication status. Thus, we tested the hypothesis that functional connectivity in RSNs differs according to clinical status and correlates with cognition in T1DM patients, using an unbiased approach with high spatio-temporal resolution functional network.; METHODS: Resting-state magnetoencephalographic (MEG) data for T1DM patients with (n=42) and without (n=41) microvascular complications and 33 healthy participants were recorded. MEG time-series at source level were reconstructed using a recently developed atlas-based beamformer. Functional connectivity within classical frequency bands, estimated by the phase lag index (PLI), was calculated within eight commonly found RSNs. Neuropsychological tests were used to assess cognitive performance, and the relation with RSNs was evaluated.; RESULTS: Significant differences in terms of RSN functional connectivity between the three groups were observed in the lower alpha band, in the default-mode (DMN), executive control (ECN) and sensorimotor (SMN) RSNs. T1DM patients with microvascular complications showed the weakest functional connectivity in these networks relative to the other groups. For DMN, functional connectivity was higher in patients without microangiopathy relative to controls (all p<0.05). General cognitive performance for both patient groups was worse compared with healthy controls. Lower DMN alpha band functional connectivity correlated with poorer general cognitive ability in patients with microvascular complications.; DISCUSSION: Altered RSN functional connectivity was found in T1DM patients depending on clinical status. Lower DMN functional connectivity was related to poorer cognitive functioning. These results indicate that functional connectivity may play a key role in T1DM-related cognitive dysfunction

On the k-Boundedness for Existential Rules

The chase is a fundamental tool for existential rules. Several chase variants are known, which differ on how they handle redundancies possibly caused by the introduction of nulls. Given a chase variant, the halting problem takes as input a set of existential rules and asks if this set of rules ensures the termination of the chase for any factbase. It is well-known that this problem is undecidable for all known chase variants. The related problem of boundedness asks if a given set of existential rules is bounded, i.e., whether there is a predefined upper bound on the number of (breadth-first) steps of the chase, independently from any factbase. This problem is already undecidable in the specific case of datalog rules. However, knowing that a set of rules is bounded for some chase variant does not help much in practice if the bound is unknown. Hence, in this paper, we investigate the decidability of the k-boundedness problem, which asks whether a given set of rules is bounded by an integer k. We prove that k-boundedness is decidable for three chase variants, namely the oblivious, semi-oblivious and restricted chase.Comment: 20 pages, revised version of the paper published at RuleML+RR 201

Dissimilarity analysis based on diffusion maps

Compositional measurements from species assemblages define a high dimensional dataspace in which the data can form complex structures, termed manifolds. Comparing assemblages in this dataspace is difficult because the data is often sparse relative to its dimensionality and the complex structure of the manifold introduces bias and error in measurements of distance. Here, we apply diffusion maps, a manifold learning method, to find and characterize manifolds in high‐dimensional compositional data. We show that diffusion maps embed the data in reduced dimensions in which the Euclidean distance between data points approximates the distance between them along the manifold. This is especially useful when species turnover is high, as it provides a way to measure meaningful distances between assemblages even when they harbor disjoint sets of species. We anticipate diffusion maps will therefore be particularly useful for characterizing community change over large spatial and temporal scales.</jats:p

Structure-function relationships in the visual system in multiple sclerosis: an MEG and OCT study

BACKGROUND: We conducted a multi-modal optical coherence tomography (OCT) and magnetoencephalography (MEG) study to test whether there is a relationship between retinal layer integrity and electrophysiological activity and connectivity (FC) in the visual network influenced by optic neuritis (ON) in patients with multiple sclerosis (MS). METHODS: One hundred and two MS patients were included in this MEG/OCT study. Retinal OCT data were collected from the optic discs, macular region, and segmented. Neuronal activity and FC in the visual cortex was estimated from source-reconstructed resting-state MEG data by computing relative power and the phase lag index (PLI). Generalized estimating equations (GEE) were used to account for intereye within-patient dependencies. RESULTS: There was a significant relationship for both relative power and FC in the visual cortex with retinal layer thicknesses. The findings were influenced by the presence of MSON, particularly for connectivity in the alpha bands and the outer macular layers. In the absence of MSON, this relationship was dominated by the lower frequency bands (theta, delta) and inner and outer retinal layers. CONCLUSION: These results suggest that visual cortex FC more than activity alters in the presence of MSON, which may guide the understanding of FC plasticity effects following MSON

Effects of site‐selection bias on estimates of biodiversity change

Estimates of biodiversity change are essential for the management and conservation of ecosystems. Accurate estimates rely on selecting representative sites, but monitoring often focuses on sites of special interest. How such site‐selection biases influence estimates of biodiversity change is largely unknown. Site‐selection bias potentially occurs across four major sources of biodiversity data, decreasing in likelihood from citizen science, museums, national park monitoring, and academic research. We defined site‐selection bias as a preference for sites that are either densely populated (i.e., abundance bias) or species rich (i.e., richness bias). We simulated biodiversity change in a virtual landscape and tracked the observed biodiversity at a sampled site. The site was selected either randomly or with a site‐selection bias. We used a simple spatially resolved, individual‐based model to predict the movement or dispersal of individuals in and out of the chosen sampling site. Site‐selection bias exaggerated estimates of biodiversity loss in sites selected with a bias by on average 300–400% compared with randomly selected sites. Based on our simulations, site‐selection bias resulted in positive trends being estimated as negative trends: richness increase was estimated as 0.1 in randomly selected sites, whereas sites selected with a bias showed a richness change of −0.1 to −0.2 on average. Thus, site‐selection bias may falsely indicate decreases in biodiversity. We varied sampling design and characteristics of the species and found that site‐selection biases were strongest in short time series, for small grains, organisms with low dispersal ability, large regional species pools, and strong spatial aggregation. Based on these findings, to minimize site‐selection bias, we recommend use of systematic site‐selection schemes; maximizing sampling area; calculating biodiversity measures cumulatively across plots; and use of biodiversity measures that are less sensitive to rare species, such as the effective number of species. Awareness of the potential impact of site‐selection bias is needed for biodiversity monitoring, the design of new studies on biodiversity change, and the interpretation of existing data

Hydration-Scanning Tunneling Microscopy as a Reliable Method for Imaging Biological Specimens and Hydrophilic Insulators

The recently discovered high lateral conductivity of molecularly thin adsorbed water films enables investigation of biological specimens, and even of surfaces of hydrophilic insulators by scanning tunneling microscopy (STM). Here we demonstrate the capabilities of this method, which we call hydration-STM (HSTM), with images of various specimens taken in humid atmosphere: We obtained images of a glass coverslip, collagen molecules, tobacco mosaic virus, lipid bilayers and cryosectioned bovine achilles tendon on mica. To elucidate the physical mechanism of this conduction phenomenon we recorded current-voltage curves on hydrated mica. This revealed a basically ohmic behavior of the J-V curves without a threshold voltage to activate the current transport and indicates that electrochemistry probably does not dominate the surface conductivity. We assume that the conduction mechanism is due to structuring of water at the surface