Incommensurate chirality density wave transition in a hybrid molecular framework

Using single-crystal X-ray diffraction we characterise the 235\,K incommensurate phase transition in the hybrid molecular framework tetraethylammonium silver(I) dicyanoargentate, [NEt$_4$]Ag$_3$(CN)$_4$. We demonstrate the transition to involve spontaneous resolution of chiral [NEt$_4$]$^+$ conformations, giving rise to a state in which molecular chirality is incommensurately modulated throughout the crystal lattice. We refer to this state as an incommensurate chirality density wave (XDW) phase, which represents a fundamentally new type of chiral symmetry breaking in the solid state. Drawing on parallels to the incommensurate ferroelectric transition of NaNO$_2$ we suggest the XDW state arises through coupling between acoustic (shear) and molecular rotoinversion modes. Such coupling is symmetry-forbidden at the Brillouin zone centre but symmetry-allowed for small but finite modulation vectors $\mathbf q=[0,0,q_z]^\ast$. The importance of long-wavelength chirality modulations in the physics of this hybrid framework may have implications for the generation of mesoscale chiral textures, as required for advanced photonic materials.Comment: 5 pages, 3 figure

Radioactive Needlework, Reconstruction of needle-positions in radiation treatment

Nucletron presented a medical problem to the SWI 2006: how to find needles used for cancer treatment in a prostate? More concretely: how to find the positions of these needles from distorted images from an ultrasound probe? Section 1 explains the background of this problem. In Section 2 we deal with physical explanations for the distortions. In Section 3 we give a brief overview of medical imaging and explain which techniques we used to clean up the images

Optical spectroscopy of two overlapping, flux-density-limited samples of radio sources in the North Ecliptic Cap, selected at 38 MHz and 151 MHz

We present the results of optical spectroscopy of two flux-density-limited samples of radio sources selected at frequencies of 38 and 151 MHz in the same region around the North Ecliptic Cap, the 8C-NEC and 7C-III samples respectively. Both samples are selected at flux density levels ~20 times fainter than samples based on the 3C catalogue. They are amongst the first low-frequency selected samples with no spectral or angular size selection for which almost complete redshift information has been obtained and they will therefore provide a valuable resource for understanding the cosmic evolution of radio sources and their hosts and environments. The 151-MHz 7C-III sample is selected to have S_151 >=0.5 Jy and is the more spectroscopically complete; out of 54 radio sources fairly reliable redshifts have been obtained for 44 objects. The 8C sample has a flux limit of S_38 >=1.3 Jy and contains 58 sources of which 46 have fairly reliable redshifts. We discuss possible biases in the observed redshift distribution, and some interesting individual objects. Using the 8C-NEC and 7C-III samples in conjunction, we form the first sample selected on low-frequency flux in the rest-frame of the source, rather than the usual selection on flux density in the observed frame. This allows us to remove the bias associated with an increasing rest-frame selection frequency with redshift. We investigate the difference this selection makes to correlations of radio source properties with redshift and luminosity. We show in particular that flux-density-based selection leads to an overestimate of the steepness of the correlation of radio source size with redshift. (abridged)Comment: 22 pages, 10 figures, accepted by MNRA

Perfectionism in Sport, Dance, and Exercise

Perfect performance, flawlessness, and the perfect body are revered in sport, dance, and exercise. As such, sport, dance, and exercise provide ideal domains in which to study perfectionism. This chapter provides an overview of research that has examined multidimensional perfectionism in these domains. We place particular emphasis on the most recent research in this area and provide suggestions to guide future research. It will be argued that perfectionism is a complex characteristic with particular relevance in sport, dance, and exercise. In addition, in its various guises, perfectionism can be problematic, beneficial, and also ambivalent with regards to motivation, well-being, and performance. To better understand the effects of perfectionism in sport, dance, and exercise, we call for research that adopts longitudinal designs, examines moderating factors, develops and refines measurement tools, and focuses on the influence of perfectionism among exercisers

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deterioration. Conventional cough monitors accurately report cough counts over short time periods. We describe a novel monitoring system which we used to record cough continuously for up to 45 days during AE-COPD convalescence. Methods This is a longitudinal, observational study of cough monitoring in AE-COPD patients discharged from a single teaching-hospital. Ambient sound was recorded from two sites in the domestic environment and analysed using novel cough classifier software. For comparison, the validated hybrid HACC/LCM cough monitoring system was used on days 1, 5, 20 and 45. Patients were asked to record symptoms daily using diaries. Results Cough monitoring data were available for 16 subjects with a total of 568 monitored days. Daily cough count fell significantly from mean±SEM 272.7±54.5 on day 1 to 110.9±26.3 on day 9 (p<0.01) before plateauing. The absolute cough count detected by the continuous monitoring system was significantly lower than detected by the hybrid HACC/LCM system but normalised counts strongly correlated (r=0.88, p<0.01) demonstrating an ability to detect trends. Objective cough count and subjective cough scores modestly correlated (r=0.46). Conclusions Cough frequency declines significantly following AE-COPD and the reducing trend can be detected using continuous ambient sound recording and novel cough classifier software. Objective measurement of cough frequency has the potential to enhance our ability to monitor the clinical state in patients with COPD

Compressible magma flow in a two-dimensional elastic-walled dike

The ascent of magma to the Earth's surface is commonly modeled by assuming a fixed dike or flow geometry from a deep subsurface reservoir to the surface. In practice, however, this flow geometry is produced by deformation of the crust by ascending overpressured magma. Here, we explore how this elastic deformation is coupled to magma ascent using a model of a planar dike whose width is allowed to evolve with depth in the crust. The model predicts that, for points well below the surface, the dike gradually narrows with height above the source reservoir as the overpressure of the magma relative to the minimum horizontal stress in the crust decreases. For a bubbly compressible magma, the flow accelerates to the surface and reaches the speed of sound at the vent, as for rigid conduit flow. However, it is now able to decompress to atmospheric pressure at the vent by contraction of the conduit. Our calculations predict eruption rates on the order of 0.1–10 $m^2/s$ per unit length of a dike, for magma supplied from a reservoir with overpressure in the range − 10 MPa to + 20 MPa

Incidence of keratitis of varying severity among contact lens wearers

AIM: To determine the incidence of non-severe keratitis (NSK) and severe keratitis (SK) among wearers of current generation contact lenses. METHODS: A 12 month, prospective, hospital based epidemiological study was conducted by examining all contact lens wearers presenting with a corneal infiltrate/ulcer to a hospital centre in Manchester. A clinical severity matrix was used to differentiate between NSK and SK, based on the severity of signs and symptoms. The size of the hospital catchment population and the wearing modalities (daily wear (DW) or extended wear (EW)) and lens types being used were estimated from relevant demographic and market data. RESULTS: During the survey period, 80 and 38 patients presented with NSK and SK, respectively. The annual incidences (cases per 10,000 wearers) for each wearing modality and lens type were: DW rigid--NSK 5.7, SK 2.9; DW hydrogel daily disposable--NSK 9.1, SK 4.9; DW hydrogel (excluding daily disposable)--NSK 14.1, SK 6.4; DW silicone hydrogel--NSK 55.9, SK 0.0; EW rigid--NSK 0.0, SK 0.0; EW hydrogel--NSK 48.2, SK 96.4; EW silicone hydrogel--NSK 98.8, SK 19.8. The difference in SK between EW hydrogel and EW silicone hydrogel was significant (p = 0.04). CONCLUSIONS: A clinical severity matrix has considerable utility in assessing contact lens related keratitis. There is a significantly higher incidence of SK in wearers who sleep in contact lenses compared with those who only use lenses during the waking hours. Those who choose to sleep in lenses should be advised to wear silicone hydrogel lenses, which carry a five times decreased risk of SK for extended wear compared with hydrogel lenses

Characterization of the stimulators of protein-directed ribosomal frameshifting in Theiler's murine encephalomyelitis virus.

Many viruses utilize programmed -1 ribosomal frameshifting (-1 PRF) to express additional proteins or to produce frameshift and non-frameshift protein products at a fixed stoichiometric ratio. PRF is also utilized in the expression of a small number of cellular genes. Frameshifting is typically stimulated by signals contained within the mRNA: a 'slippery' sequence and a 3'-adjacent RNA structure. Recently, we showed that -1 PRF in encephalomyocarditis virus (EMCV) is trans-activated by the viral 2A protein, leading to a temporal change in PRF efficiency from 0% to 70% during virus infection. Here we analyzed PRF in the related Theiler's murine encephalomyelitis virus (TMEV). We show that 2A is also required for PRF in TMEV and can stimulate PRF to levels as high as 58% in rabbit reticulocyte cell-free translations and 81% during virus infection. We also show that TMEV 2A trans-activates PRF on the EMCV signal but not vice versa. We present an extensive mutational analysis of the frameshift stimulators (mRNA signals and 2A protein) analysing activity in in vitro translation, electrophoretic mobility shift and in vitro ribosome pausing assays. We also investigate the PRF mRNA signal with RNA structure probing. Our results substantially extend previous characterization of protein-stimulated PRF