Digital Mental Health and Social Connectedness

A detailed understanding of the mental health needs of people from refugee backgrounds is crucial for the design of inclusive mental health technologies. We present a qualitative account of the digital mental health experiences of women from refugee backgrounds. Working with community members and community workers of a charitable organisation for refugee women in the UK, we identify social and structural challenges, including loneliness and access to mental health technologies. Participants' accounts document their collective agency in addressing these challenges and supporting social connectedness and personal wellbeing in daily life: participants reported taking part in community activities as volunteers, sharing technological expertise, and using a wide range of non-mental health-focused technologies to support their mental health, from playing games to supporting religious practices. Our findings suggest that, rather than focusing only on individual self-care, research also needs to leverage community-driven approaches to foster social mental health experiences, from altruism to connectedness and belonging

Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Gaussia luciferase (GLuc) is a secreted protein with significant potential for use as a reporter of gene expression in bacterial pathogenicity studies. To date there are relatively few examples of its use in bacteriology. In this study we show that GLuc can be functionally expressed in the human pathogen Staphylococcus aureus and furthermore show that it can be used as a biosensor for the agr quorum sensing (QS) system which employs autoinducing peptides to control virulence. GLuc was linked to the P3 promoter of the S. aureus agr operon. Biosensor strains were validated by evaluation of chemical agent-mediated activation and inhibition of agr. Use of GLuc enabled quantitative assessment of agr activity. This demonstrates the utility of Gaussia luciferase for in vitro monitoring of agr activation and inhibition

Two 100 Mpc-scale structures in the 3-D distribution of radio galaxies and their implications

We present unequivocal evidence for a huge (~80 x 100 x 100 Mpc^3) super-structure at redshift z=0.27 in the 3-D distribution of radio galaxies from the TONS08 sample, confirming tentative evidence for such a structure from the 7C redshift survey (7CRS). A second, newly discovered super-structure is also less securely found at redshift 0.35 (of dimensions ~100 x 100 x 100 Mpc^3). We present full observational details on the TONS08 sample which was constructed to probe structures in the redshift range 0 < z < 0.5 by matching NVSS sources with objects in APM catalogues to obtain a sample of optically bright (E ~ R 3 mJy) radio galaxies in the same 25 deg^2 area as part-II of the 7CRS. Out of the total sample size of 84 radio galaxies, at least 25 are associated with the two ~100 Mpc-scale super-structures. We use quasi-linear structure formation theory to estimate the number of such structures expected in the TONS08 volume if the canonical value for radio galaxy bias is assumed. Under this assumption, the structures represent ~ 4-5 sigma peaks in the primordial density field and their expected number is low (~10^-2 - 10^-4). Fortunately, there are several plausible explanations (many of which are testable) for these low probabilities in the form of potential mechanisms for boosting the bias on large scales. These include: the association of radio galaxies with highly biased rich clusters in super-structures, enhanced triggering by group/group mergers, and enhanced triggering and/or redshift space distortion in collapsing systems as the growth of super-structures moves into the non-linear regime (abridged).Comment: Accepted for publication in MNRAS. 26 pages,16 figures. spectra can be found in: http://www-astro.physics.ox.ac.uk/~brand/08_paper.ps.g

Approaches to developing tolerance and error budget for active three mirror anastigmat space telescopes

The size of the optics used in observatories is often limited by fabrication, metrology, and handling technology, but having a large primary mirror provides significant benefits for scientific research. The evolution of rocket launch options enables heavy payload carrying on orbit and outstretching the telescope's form-factor choices. Moreover, cost per launch is lower than the traditional flight method, which is obviously advantageous for various novel space observatory concepts. The University of Arizona has successfully fabricated many large-scale primary optics for ground-based observatories including the Large Binocular Telescope (LBT, 8.4 meter diameter two primary mirrors), Large Synoptic Survey Telescope (now renamed to Vera C. Rubin Observatory, 8.4 meter diameter monolithic primary and tertiary mirror), and the Giant Magellan Telescope (GMT, 8.4 meter diameter primary mirror seven segments). Launching a monolithic primary mirror into space could bypass many of the difficulties encountered during the assembly and deployment of the segmented primary mirrors. However, it might bring up unprecedented challenges and hurdles, also. We explore and foresee the expected challenges and evaluate them. To estimate the tolerance and optical error budget of a large optical system in space such as three mirror anastigmat telescope, we have developed a methodology that considers various errors from design, fabrication, assembly, and environmental factors.Comment: 6 pages, presented August 2023 at SPIE Optics+Photonics, San Diego, CA, US

Explanation before Adoption: Supporting Informed Consent for Complex Machine Learning and IoT Health Platforms

Explaining health technology platforms to non-technical members of the public is an important part of the process of informed consent. Complex technology platforms that deal with safety-critical areas are particularly challenging, often operating within private domains (e.g. health services within the home) and used by individuals with various understandings of hardware, software, and algorithmic design. Through two studies, the first an interview and the second an observational study, we questioned how experts (e.g. those who designed, built, and installed a technology platform) supported provision of informed consent by participants. We identify a wide range of tools, techniques, and adaptations used by experts to explain the complex SPHERE sensor-based home health platform, provide implications for the design of tools to aid explanations, suggest opportunities for interactive explanations, present the range of information needed, and indicate future research possibilities in communicating technology platforms

Polarimetric modeling and assessment of science cases for Giant Magellan Telescope-Polarimeter (GMT-Pol)

Polarization observations through the next-generation large telescopes will be invaluable for exploring the magnetic fields and composition of jets in AGN, multi-messenger transients follow-up, and understanding interstellar dust and magnetic fields. The 25m Giant Magellan Telescope (GMT) is one of the next-generation large telescopes and is expected to have its first light in 2029. The telescope consists of a primary mirror and an adaptive secondary mirror comprising seven circular segments. The telescope supports instruments at both Nasmyth as well as Gregorian focus. However, none of the first or second-generation instruments on GMT has the polarimetric capability. This paper presents a detailed polarimetric modeling of the GMT for both Gregorian and folded ports for astronomical B-K filter bands and a field of view of 5 arc minutes. At 500nm, The instrumental polarization is 0.1% and 3% for the Gregorian and folded port, respectively. The linear to circular crosstalk is 0.1% and 30% for the Gregorian and folded ports, respectively. The Gregorian focus gives the GMT a significant competitive advantage over TMT and ELT for sensitive polarimetry, as these telescopes support instruments only on the Nasmyth platform. We also discuss a list of polarimetric science cases and assess science case requirements vs. the modeling results. Finally, we discuss the possible routes for polarimetry with GMT and show the preliminary optical design of the GMT polarimeter.Comment: 13 pages, 5 figures,SPIE Optics + Photonics 2023 conference proceeding, Paper no 12690-2

Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years

This is the final version. Available on open access from BMJ Publishing Group via the DOI in this recordObjective: To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18 to 50. Design: Multivariable logistic regression analysis was used to develop classification models integrating five pre-specified predictor variables, including clinical features (age of diagnosis, BMI) and clinical biomarkers (GADA and Islet Antigen 2 islet autoantibodies, Type 1 Diabetes Genetic Risk Score), to identify type 1 diabetes with rapid insulin requirement using data from existing cohorts. Setting: United Kingdom cohorts recruited from primary and secondary care. Participants: 1,352 (model development) and 582 (external validation) participants diagnosed with diabetes between the age of 18 and 50 years of white European origin. Main outcome measures: Type 1 diabetes was defined by rapid insulin requirement (within 3 years of diagnosis) and severe endogenous insulin deficiency (C-peptide <200pmol/L). Type 2 diabetes was defined by either a lack of rapid insulin requirement or, where insulin treated within 3 years, retained endogenous insulin secretion (C-peptide >600pmol/L at ≥5 years diabetes duration). Model performance was assessed using area under the receiver operating characteristic curve (ROC AUC), and internal and external validation. 4 Results: Type 1 diabetes was present in 13% of participants in the development cohort. All five predictor variables were discriminative and independent predictors of type 1 diabetes (p<0.001 for all) with individual ROC AUC ranging from 0.82 to 0.85. Model performance was high: ROC AUC range 0.90 [95%CI 0.88, 0.93] (clinical features only) to 0.97 [0.96, 0.98] (all predictors) with low prediction error. Results were consistent in external validation (clinical features and GADA ROC AUC 0.93 [0.90, 0.96]). Conclusions: Clinical diagnostic models integrating clinical features with biomarkers have high accuracy for identifying type 1 diabetes with rapid insulin requirement, and could assist clinicians and researchers in accurately identifying patients with type 1 diabetes.National Institute for Health Research (NIHR)European Community FP7Oxford Hospitals Charitable FundWellcome TrustMedical Research Council (MRC

Appetite, appetite hormone and energy intake responses to two consecutive days of aerobic exercise in healthy young men

Single bouts of exercise do not cause compensatory changes in appetite, food intake or appetite regulatory hormones on the day that exercise is performed. It remains possible that such changes occur over an extended period or in response to a higher level of energy expenditure. This study sought to test this possibility by examining appetite, food intake and appetite regulatory hormones (acylated ghrelin, total peptide-YY, leptin and insulin) over two days, with acute bouts of exercise performed on each morning. Within a controlled laboratory setting, 15 healthy males completed two, 2-day long (09:00–16:00) experimental trials (exercise and control) in a randomised order. On the exercise trial participants performed 60 min of continuous moderate-high intensity treadmill running (day one: 70.1 ± 2.5% VO2peak, day two: 70.0 ± 3.2% VO2max (mean ± SD)) at the beginning of days one and two. Across each day appetite perceptions were assessed using visual analogue scales and appetite regulatory hormones were measured from venous blood samples. Ad libitum energy and macronutrient intakes were determined from meals provided two and six hours into each day and from a snack bag provided in-between trial days. Exercise elicited a high level of energy expenditure (total = 7566 ± 635 kJ across the two days) but did not produce compensatory changes in appetite or energy intake over two days (control: 29,217 ± 4006 kJ; exercise: 28,532 ± 3899 kJ, P > 0.050). Two-way repeated measures ANOVA did not reveal any main effects for acylated ghrelin or leptin (all P > 0.050). However a significant main effect of trial (P = 0.029) for PYY indicated higher concentrations on the exercise vs. control trial. These findings suggest that across a two day period, high volume exercise does not stimulate compensatory appetite regulatory changes

The ugrizYJHK luminosity distributions and densities from the combined MGC, SDSS and UKIDSS LAS datasets

We combine data from the MGC, SDSS and UKIDSS LAS surveys to produce ugrizYJHK luminosity functions and densities from within a common, low redshift volume (z<0.1, ~71,000 h_1^-3 Mpc^3 for L* systems) with 100 per cent spectroscopic completeness. In the optical the fitted Schechter functions are comparable in shape to those previously reported values but with higher normalisations (typically 0, 30, 20, 15, 5 per cent higher phi*-values in u, g, r, i, z respectively over those reported by the SDSS team). We attribute these to differences in the redshift ranges probed, incompleteness, and adopted normalisation methods. In the NIR we find significantly different Schechter function parameters (mainly in the M* values) to those previously reported and attribute this to the improvement in the quality of the imaging data over previous studies. This is the first homogeneous measurement of the extragalactic luminosity density which fully samples both the optical and near-IR regimes. Unlike previous compilations that have noted a discontinuity between the optical and near-IR regimes our homogeneous dataset shows a smooth cosmic spectral energy distribution (CSED). After correcting for dust attenuation we compare our CSED to the expected values based on recent constraints on the cosmic star-formation history and the initial mass function.Comment: 17 pages, 13 figures, Accepted in MNRAS: 2010 January 18; in original form 2009 August 1