The Development of a Screening Questionnaire for Obstructive Sleep Apnea in Children with Down Syndrome

Obstructive sleep apnea is a condition which affects an estimated 50% of children with Down syndrome, particularly in their early years. It can cause serious sequelae in affected children but may not be recognized by parents or health professionals. Routine screening has been recommended in some countries, but is not standard practice. There are no validated questionnaire-based tools available to screen this population of children for this particular sleep-related disorder. Using existing validated sleep questionnaire items, we have developed a questionnaire to screen children with Down syndrome up to 6 years of age for obstructive sleep apnea, which corresponds with the recommendations made in UK national guidelines. This paper describes these first steps in demonstrating content validity for a new questionnaire, which will be subject to further in-depth psychometric analysis. Relevance, clarity, and age appropriateness were rated for 33 items using a content review questionnaire by a group of 18 health professionals with expertise in respiratory pediatrics, neurodevelopmental pediatrics, and sleep physiology. The content validity index was calculated for individual items and contributed to decisions about item inclusion. Scale level content validity index for the modified questionnaire of 14 items was at an accepted level of 0.78. Two parents of children with Down syndrome took part in cognitive interviews after completing the modified questionnaire. We describe the development of this 14 item questionnaire to screen for OSA in children with DS from infancy to 6 years

Calcium Hydride Reduction of Polycyclic Aromatic Hydrocarbons

A molecular calcium hydride effects the two electron reduction of polyaromatic hydrocarbons, including naphthalene (E0=−3.1 V)

Reduction of Na+ within a {Mg2Na2} Assembly

Ionic compounds containing sodium cations are notable for their stability and resistance to redox reactivity unless highly reducing electrical potentials are applied. Here we report that treatment of a low oxidation state {Mg2Na2} species with non‐reducible organic bases induces the spontaneous and completely selective extrusion of sodium metal and oxidation of the MgI centers to the more conventional MgII state. Although these processes are also characterized by a structural reorganisation of the initially chelated diamide spectator ligand, computational quantum chemical studies indicate that intramolecular electron transfer is abetted by the frontier molecular orbitals (HOMO/LUMO) of the {Mg2Na2} ensemble, which arise exclusively from the 3s valence atomic orbitals of the constituent sodium and magnesium atoms

A yield gap analysis to assess vulnerability of commercial sugarcane to climatic extremes in southern Africa

Sugarcane yields have steadily declined across southern Africa for the past 25 years and, despite research into the causes, there has been limited progress in addressing these trends. This study developed a methodology of assessing yield declines and performed a yield gap analysis to assess and develop recommendations to assist in combating yield declines and offering potential safeguards for the sugarcane industry against climatic extremes. Mill areas from South Africa, eSwatini, Malawi and Tanzania were selected, providing a diversity of regional hydroclimatic conditions and sugarcane agronomic management approaches. Using the AquaCrop crop model, maximum potential yields and yield gaps were simulated based on observed climate and yield data spanning 25 years. Results show that yields are declining for the mill areas in South Africa, Malawi and Tanzania, resulting in increased yield gaps, whilst yields are stagnant in eSwatini resulting in relatively fixed yield gaps. Yield gaps remained high across all six mill areas, suggesting that they remain vulnerable and exposed to climatic extremes. Modelling results suggest that these yield trends, including yield gaps, are primarily attributed to existing crop management approaches as opposed to the climatic regimes in these areas. Recommendations include several solutions that could result in an immediate response and reduce yield gaps while increasing harvestable yields. Such measures include increasing technology transfer and agronomic management education to small-scale outgrowers, adopting drought-resistant, high-yielding sugarcane varieties, contouring and mulching, improving soil structural properties and minimizing in-field traffic. The study concludes that if sugarcane growers are to withstand the effects of extreme climatic events, they have to consider shifting crop management approaches and be proactively included in related research.http://www.sciencedirect.com/journal/journal-of-agriculture-and-food-researchGeography, Geoinformatics and Meteorolog

An assessment of the vulnerability and adaptation potential of sugarcane production to water stress, southern Africa

DATA AVAILABILITY : Data will be made available on request.The high spatial variability of precipitation, heightened frequency of droughts and concomitant increases in exposure to water stress across southern Africa due to climate change, presents significant challenges for sugarcane production and the regional sugarcane production value chain. While production has intensified in the past few decades, yields have declined due to increased climatic variability and agronomic management approaches. Increased precipitation variability has enhanced sugarcane vulnerability to water stress and is likely to negatively affect yields. Combining crop simulations and relationships between sugarcane water use and observed rainfall, we introduce a crop productivity ratio (CPR) which assesses sugarcane water stress for six sugarcane mills across southern Africa. The CPR and simulation results were used to assess the adaptation potential or ‘space’ for mill areas that have varying rates of exposure and abilities to adapt to water stress. Simulation results were used to determine the long-term adaption potential of mill areas and to surmise the causes of yield declines. The results were used to offer recommendations to reduce vulnerabilities and enhance adaptation to water stress. We conclude that the amplification of inter-annual precipitation variability will enhance the exposure of sugarcane to water stress and require adaptation interventions. Adapting to external shocks is a multifaceted exercise that requires a holistic approach that includes every aspect of the sugarcane value chain.The University of KwaZulu-Natal's Centre for Water Resources Research (CWRR).http://www.sciencedirect.com/journal/journal-of-agriculture-and-food-researchhj2024Geography, Geoinformatics and MeteorologySDG-02:Zero HungerSDG-13:Climate actio

Muncie's Public Art Messaging: public art audit. What are we communicating: a collaboration between COMM 450 & MACC

During the Spring 2022 semester, students enrolled in COMM 450 studied the intersections between rhetoric, advocacy, and activism at the local level. Specifically, the class explored how public art serves as public advocacy in Muncie. This report is a cumulation of the class's public art audit and was shared with the Muncie Arts and Culture Council

[{SiNDipp}MgNa]2: A potent molecular reducing agent

The bimetallic species, [{SiNDipp}MgNa]2 [{SiNDipp} = {CH2SiMe2N(Dipp)}2; (Dipp = 2,6-i-Pr2C6H3)], is shown to be a potent reducing agent, able to effect one- or two-electron reduction of either dioxygen, TEMPO, anthracene, benzophenone, or diphenylacetylene. In most cases, the bimetallic reaction products imply that the dissimilar alkaline metal centers react with a level of cooperativity. EPR analysis of the benzophenone-derived reaction and the concurrent isolation of [{SiNDipp}Mg(OCPh2)2], however, illustrate that treatment with such reducible, but O-basic, species can also result in reactivity in which the metals provide independent reaction products. The notable E-stereochemistry of the diphenylacetylene reduction product prompted a computational investigation of the PhC≡CPh addition. This analysis invokes a series of elementary steps that necessitate ring-opening via Mg+ → Na+ amido group migration of the SiNDipp ligand, providing insight into the previously observed lability of the bidentate dianion and its consequent proclivity toward macrocyclization

Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity

Augmented T cell function leading to host damage in autoimmunity is supported by metabolic dysregulation, making targeting immunometabolism an attractive therapeutic avenue. Canagliflozin, a type 2 diabetes drug, is a sodium glucose co-transporter 2 (SGLT2) inhibitor with known off-target effects on glutamate dehydrogenase and complex I. However, the effects of SGLT2 inhibitors on human T cell function have not been extensively explored. Here, we show that canagliflozin-treated T cells are compromised in their ability to activate, proliferate, and initiate effector functions. Canagliflozin inhibits T cell receptor signaling, impacting on ERK and mTORC1 activity, concomitantly associated with reduced c-Myc. Compromised c-Myc levels were encapsulated by a failure to engage translational machinery resulting in impaired metabolic protein and solute carrier production among others. Importantly, canagliflozin-treated T cells derived from patients with autoimmune disorders impaired their effector function. Taken together, our work highlights a potential therapeutic avenue for repurposing canagliflozin as an intervention for T cell-mediated autoimmunity

Mental Health Through Movement

Children’s mental health: ‘has become an issue of real concern, in the media and to both politicians and NHS leaders, over the last five years in particular. It has prompted numerous inquiries, reports, recommendations and pledges by politicians and NHS leaders to improve the situation’: https://www.theguardian.com/society/2018/nov/22/what-is-happening-withchildrens-mental-health On July 1st 2019, the Local Government Association released statistics to show that: ‘There were 205,720 cases where a child was identified as having a mental health issue in 2017/18, compared with 133,600 in 2014/15- up 54%’: https://www.local.gov.uk/about/news/councils-seeing-more-560-child-mentalhealth-cases-every-day It is within this context that the All-Party Parliamentary Group on A Fit and Healthy Childhood presents its 14th Report: ‘Positive Mental Health Through Movement’. With 1 in 10 children now having a mental health diagnosis and 1 in 4 an undiagnosed mental health issue, this, our third Report on the issue of child mental health, addresses the link between positive mental health and physical activity and movement experiences at a time when, paradoxically, today’s children and young people are more inactive and play less than ever before. The growing recognition of a link between mental health and movement is fortuitous because from September 2019, health education in English schools will be statutory alongside the expectation that they will offer their pupils at least 30 ‘active minutes’ per day. The APPG on A Fit and Healthy Childhood welcomes the change whilst recognising that those responsible for implementing the new strategy (including practitioners and families) will need guidance as they help children to develop individual strategies to address future adverse events and foster the positive sense of self that will enable them to lead fulfilled, healthy lives. This Report is therefore presented as a practical contribution to an essential debate. It offers new strategies against the persistence of historical and traditional ways of thinking; examines and collates best practice in the devolved Home Countries as well as the wider world and discusses exactly what is required to ensure that future child mental health strategy is holistic. It is respectful of equalities and is aware that the successful outcome of policies is entirely dependent upon the expertise and confidence of those tasked with the responsibility of delivering them. As the 21st century advances, we consider the effects of the digital age and its impact on children and young people’s mental health and wellbeing and the crucial role of parents and carers who want the best for their children in a societal climate where, all too often, fears of ‘nanny state’ meddling serve to isolate families who suffer in silence – until a disaster that may have been all too predictable and preventable overtakes them, making a private grief a public concern. The trajectory of progress in mental health policy has been ‘stop start’ rather than linear, with legislative change in 1959 and 1983, an increase in spending from 1997- 2010 and radical changes to child and adolescent mental health services (CAMHS) in 2000. The Wessely Independent Review of the Mental Health Act is another such milestone: https://www.gov.uk/government/groups/independent-review-of-the-mentalhealth-act The APPG on A Fit and Healthy Childhood anticipates that the Government will fulfil its pledge to parents, children and practitioners by introducing much needed mental health legislation - and that our trio of Reports and the holistic theme of this one will help to inform a strategy that works for 21st century children