8,118 research outputs found

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    Natural Supplements for H1N1 Influenza: Retrospective Observational Infodemiology Study of Information and Search Activity on the Internet

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    Background: As the incidence of H1N1 increases, the lay public may turn to the Internet for information about natural supplements for prevention and treatment. Objective: Our objective was to identify and characterize websites that provide information about herbal and natural supplements with information about H1N1 and to examine trends in the public’s behavior in searching for information about supplement use in preventing or treating H1N1. Methods: This was a retrospective observational infodemiology study of indexed websites and Internet search activity over the period January 1, 2009, through November 15, 2009. The setting is the Internet as indexed by Google with aggregated Internet user data. The main outcome measures were the frequency of “hits” or webpages containing terms relating to natural supplements co-occurring with H1N1/swine flu, terms relating to natural supplements co-occurring with H1N1/swine flu proportional to all terms relating to natural supplements, webpage rank, webpage entropy, and temporal trend in search activity. Results: A large number of websites support information about supplements and H1N1. The supplement with the highest proportion of H1N1/swine flu information was a homeopathic remedy known as Oscillococcinum that has no known side effects; supplements with the next highest proportions have known side effects and interactions. Webpages with both supplement and H1N1/swine flu information were less likely to be medically curated or authoritative. Search activity for supplements was temporally related to H1N1/swine flu-related news reports and events. Conclusions: The prevalence of nonauthoritative webpages with information about supplements in the context of H1N1/swine flu and the increasing number of searches for these pages suggest that the public is interested in alternatives to traditional prevention and treatment of H1N1. The quality of this information is often questionable and clinicians should be cognizant that patients may be at risk of adverse events associated with the use of supplements for H1N1

    Impact of Post-Operative Complications on Quality of Life After Pancreatectomy

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    Purpose This study was undertaken to analyze the quality of life changes reported by patients with pancreatic cancer undergoing pancreatectomy. Design Post-hoc analysis was performed of a clinical trial examining the safety of intraoperative autotransfusion during oncologic resections. Main outcome measures Perioperative (90-day) complications were graded prospectively using a validated 5-point scale. Quality of life parameters were recorded prospectively by a single trained interviewer preoperatively, at the first post-operative outpatient visit, and at 6 weeks, 3 months, and 6 months follow-up using the EORTC QLQ-C30 and FACT-An instruments. Results Pancreatectomy for adenocarcinoma was performed in 34 patients with a median follow-up of 2 years (range: 1-1.5 years). Major (grade ≥ 3) complications occurred in 12 (35.3%) of patients. Early (<6 month) recurrence was noted in 2 patients (5.9%). Increased severity of fatigue, pain, dyspnea, and loss of appetite over baseline were noted at initial follow-up (P<0.05); however, symptom scores normalized at 6-week follow-up, and remained stable at 6 months. No significant difference was noted in quality of life metrics between patients with or without major complications (P>0.11). A significant (P=0.023) decline in cognitive function vs. baseline was noted at 6-month follow-up after pancreatectomy. Using a repeated-measures generalized linear model, neither age, nor complication occurrence, nor adjuvant therapy, nor early recurrence accounted for this cognitive decline (P>0.10). Conclusion Quality of life metrics tend to normalize to preoperative levels after pancreatectomy at 6 weeks post-operatively. The occurrence of major complications does not predict a decreased quality of life. The decrease in self-reported cognitive function at six months in this cohort merits further study.Image: FACT physical well-being

    Asteroid Distributions in the Ecliptic

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    We present analysis of the asteroid surface density distribution of main belt asteroids (mean perihelion Δ2.404\Delta \simeq 2.404 AU) in five ecliptic latitude fields, -17 \gtsimeq \beta(\degr) \ltsimeq +15, derived from deep \textit{Large Binocular Telescope} (LBT) VV-band (85% completeness limit V=21.3V = 21.3 mag) and \textit{Spitzer Space Telescope} IRAC 8.0 \micron (80% completeness limit 103μ\sim 103 \muJy) fields enabling us to probe the 0.5--1.0 km diameter asteroid population. We discovered 58 new asteroids in the optical survey as well as 41 new bodies in the \textit{Spitzer} fields. The derived power law slopes of the number of asteroids per square degree are similar within each 5\sim 5\degr{} ecliptic latitude bin with a mean value of 0.111±0.077 -0.111 \pm 0.077. For the 23 known asteroids detected in all four IRAC channels mean albedos range from 0.24±0.070.24 \pm 0.07 to 0.10±0.050.10 \pm 0.05. No low albedo asteroids (pVp_{V} \ltsimeq 0.1) were detected in the \textit{Spitzer} FLS fields, whereas in the SWIRE fields they are frequent. The SWIRE data clearly samples asteroids in the middle and outer belts providing the first estimates of these km-sized asteroids' albedos. Our observed asteroid number densities at optical wavelengths are generally consistent with those derived from the Standard Asteroid Model within the ecliptic plane. However, we find an over density at \beta \gtsimeq 5\degr{} in our optical fields, while the infrared number densities are under dense by factors of 2 to 3 at all ecliptic latitudes.Comment: 35 pages including 5 figures, accepted to The Astronomical Journa
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