8 research outputs found
ΠΠΎΠΈ Π²ΠΎΡΠΏΠΎΠΌΠΈΠ½Π°Π½ΠΈΡ ΠΎΠ± ΠΠ²Π°Π½Π΅ ΠΠ΅ΠΎΡΠ³ΠΈΠ΅Π²ΠΈΡΠ΅ Π‘ΠΏΠ°ΡΡΠΊΠΎΠΌ
Π‘ΡΠΈΡΠ»Ρ ΡΠΏΠΎΠ³Π°Π΄ΠΈ Π°Π²ΡΠΎΡΠ° ΠΏΡΠΎ Π²ΡΠ΄ΠΎΠΌΠΎΠ³ΠΎ Π²ΡΠ΅Π½ΠΎΠ³ΠΎ-Π½ΡΠΌΡΠ·ΠΌΠ°ΡΠ° ΠΉ ΠΌΡΠ·Π΅ΠΉΠ½ΠΈΠΊΠ° Π.Π. Π‘ΠΏΠ°ΡΡΠΊΠΎΠ³ΠΎ ΡΠ° ΠΉΠΎΠ³ΠΎ ΡΡΠΌβΡ.ΠΡΠ°ΡΠΊΠΈΠ΅ Π²ΠΎΡΠΏΠΎΠΌΠΈΠ½Π°Π½ΠΈΡ Π°Π²ΡΠΎΡΠ° ΠΎΠ± ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎΠΌ ΡΡΠ΅Π½ΠΎΠΌ-Π½ΡΠΌΠΈΠ·ΠΌΠ°ΡΠ΅ ΠΈ ΠΌΡΠ·Π΅ΠΉΡΠΈΠΊΠ΅ Π.Π. Π‘ΠΏΠ°ΡΡΠΊΠΎΠΌ ΠΈ Π΅Π³ΠΎ ΡΠ΅ΠΌΡΠ΅.Short authorβs memories about known scientist-numismatist and museum-worker I.G. Spassky and his family
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
Nephrolog
Functional differentiation of human T helper cells: role of antigen-presenting cell-derived factors
Investigating the role of dendritic cells in extracorporeal photopheresis using an in vitro model
Il-12-deficient dendritic cells generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
We studied to what extent the presence of an inflammatory mediator PGE2, during the development of dendritic cells (DC) affects their subsequent ability to induce Th1- and Th2-type cytokines in maturing naive Th cells. PGE2 (10(-9)-10(-6) M) did not alter the morphology or the expression of class II MHC and costimulatory molecules on DC obtained from monocytes in the presence of granulocyte-macrophage CSF and IL-4, although at concentrations above 10(-8) M, PGE2 prevented the acquisition of CD1a marker. Both control DC and DC maturing in the presence of PGE2 (PGE2-DC) were potent stimulators of naive Th cells. In contrast to control DC, which produced high amounts of IL-12 and trace amounts of IL-10, PGE2-DC produced no IL-12 and high amounts of IL-10 when stimulated in the absence of PGE2. This distinct cytokine profile of PGE2-DC was stable for at least 48 h of additional culture in the absence of PGE2. Control DC induced the development of Th0-like cells from superantigen-activated naive Th cells, whereas PGE2-DC promoted the development of Th cells that produced high amounts of IL-4 and IL-5. Experiments using IL-12-neutralizing Abs or rIL-12 indicated a crucial role of IL-12 deficiency in the induction of type 2 cytokine profiles. These findings suggest that elevated levels of PGE2 promote type 2 Th responses by stably impairing the ability of maturing DC to produce IL-12. Since type 2 Th responses are protective in several Th1-related autoimmune disorders, PGE2-DC may be considered for use in immunotherap