364 research outputs found
Exploring Galaxy Evolution from Infrared Number Counts and Cosmic Infrared Background
Recently reported infrared (IR) galaxy number counts and cosmic infrared
background (CIRB) all suggest that galaxies have experienced a strong evolution
sometime in their lifetime. We statistically estimate the galaxy evolution
history from these data. We find that an order of magnitude increase of the
far-infrared (FIR) luminosity at redshift z = 0.5 - 1.0 is necessary to
reproduce the very high CIRB intensity at 140 um reported by Hauser et al.
(1998). z \sim 0.75 and decreases to, even at most, a factor of 10 toward z
\sim 5, though many variants are allowed within these constraints. This
evolution history also satisfies the constraints from the galaxy number counts
obtained by IRAS, ISO and, roughly, SCUBA. The rapid evolution of the comoving
IR luminosity density required from the CIRB well reproduces the very steep
slope of galaxy number counts obtained by ISO. We also estimate the cosmic star
formation history (SFH) from the obtained FIR luminosity density, considering
the effect of the metal enrichment in galaxies. The derived SFH increases
steeply with redshift in 0
0.75. This is consistent with the SFH estimated from the reported ultraviolet
luminosity density. In addition, we present the performance of the Japanese
ASTRO-F FIR galaxy survey. We show the expected number counts in the survey. We
also evaluate how large a sky area is necessary to derive a secure information
of galaxy evolution up to z \sim 1 from the survey, and find that at least 50 -
300 deg^2 is required.Comment: 18 pages LaTeX, PASJ in press. Abstract abridge
Pressure-induced quantum critical point in a heavily hydrogen-doped iron-based superconductor LaFeAsO
An iron-based superconductor LaFeAsOH (0 0.6)
undergoes two antiferromagnetic (AF) phases upon H doping. We investigated the
second AF phase (=0.6) using NMR techniques under pressure. At pressures up
to 2 GPa, the ground state is a spin-density-wave state with a large gap;
however, the gap closes at 4.0 GPa, suggesting a pressure-induced quantum
critical point. Interestingly, the gapped excitation coexists with gapless
magnetic fluctuations at pressures between 2 and 4 GPa. This coexistence is
attributable to the lift up of the orbital to the Fermi level, a
Lifshitz transition under pressure
Histochemical studies on enzyme activities of gastric carcinoma. II. Dehydrogenases
With gastric carcinomas the activities of eight dehydrogenases; succmlC, lactic, malic, α glycerophosphate, glutamic, β-hydroxybutyric, glucose-6-phosphate and isocitric dehydrogenase were statistically estimated. Principal findings may be briefly summarized as follows. These enzymatic activities differed considerably even in the same classification of carcinomas and generally ranged from strong to weak in the following order: lactic, malic, glucose-6-phosphate, isocitric, succinic, α-glycerophosphate, glutamic and β-hydroxybutyric dehydrogenase. The activities of adenocarcinomas were stronger than those in simple ones, and these were not related appreciably to cell differentiation in adenocarcinomas except succinic, glutamic, glucose-6-phosphate and isocitric dehydrogenase.
As for succinic dehydrogenase and NAD-linked dehydrogenases except for lactic dehydrogenase, the activities were strongest in intestinal metaplasia and early mucosal carcinomas, the next being in benign adenomatous polyps and weakest in the other carcinomas. As for NADP-linked dehydrogenases and lactic dehydronase, the activities were also strongest in intestinal metaplasia
and early carcinomas, the second in the other carcinomas and the third in the benign polyps. Generally, these dehydrogenase activities were strongest in free carcinoma
cells in blood and lymph vessels and in actively growing part of several carcinomas and weakest in the central area of tumors, especially almost negative in the central necrotic area.</p
Histochemical studies on enzyme activities of gastric carcinoma. I. Hydrolytic enzymes
The activities of five hydrolytic enzymes, alkaline and acid phosphataSe, beta-esterase, leucine aminopeptidase and beta-glucuronidase, of human gastric carcinomas from 180 patients were investigated histochemically. Alkaline phosphatase activity was almost negative in the carcinoma but was weakly positive in this tumor at times (about 10 to 20 per cent). Acid phosphatase activity which displayed a slightly increasing tendency of the reaction in poorly differentiated tumor was variegated and mainly from feeble to moderate in activity. Beta-esterase reaction was in varying degrees with each case, but more malignant the carcinomas, the weaker was the activity. Leucine aminopeptidase was positive in about 30 to 60 per cent of the specimens observed but the reaction was founded to be localized often in some areas and generally similar to alkaline phosphatase reaction. The activities of leucine aminopeptidase, alkaline phosphatase and beta-esterase were positive at a higher rate in mucinous carcinomas than in non-mucin producing one. Beta-glucuronidase activity was slight or moderate in general but rather strong in the early stage of carcinomas.</p
ΠΠ΅Ρ Π°Π½ΡΠ·ΠΌΠΈ ΡΡΠ°ΡΡΡ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ Ρ ΡΠΎΡΠΌΡΠ²Π°Π½Π½Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ²
ΠΠΈΡΠ΅ΡΡΠ°ΡΡΡ ΠΏΡΠΈΡΠ²ΡΡΠ΅Π½Π° Π²ΠΈΡΡΡΠ΅Π½Π½Ρ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΈ Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½Ρ ΡΠΎΠ»Ρ ΡΡΠ΅ΡΠ΅ΠΎΡΠΈΠΏΠ½ΠΈΡ
ΡΠ΅Π°ΠΊΡΡΠΉ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ ΡΠΊ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ Π² ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ. Π‘ΡΠΎΡΠΌΡΠ»ΡΠΎΠ²Π°Π½Ρ Π·Π°Π³Π°Π»ΡΠ½Ρ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈ ΠΎΡΡΠ½ΠΊΠΈ ΡΡΠ°Π½Ρ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ ΡΠ° Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π° ΡΡ ΡΠΎΠ»Ρ Ρ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ Π² ΠΏΠ°ΡΠ΅Π½Ρ
ΡΠΌΠ°ΡΠΎΠ·Π½ΠΈΡ
ΠΎΡΠ³Π°Π½Π°Ρ
(Π½ΠΈΡΠΊΠΈ, ΠΏΠ΅ΡΡΠ½ΠΊΠ°, ΠΏΡΠ΄ΡΠ»ΡΠ½ΠΊΠΎΠ²Π° Π·Π°Π»ΠΎΠ·Π°) Ρ ΠΊΡΡΡΠΊΠΎΠ²ΡΠΉ ΡΠΊΠ°Π½ΠΈΠ½Ρ. ΠΠΏΠ΅ΡΡΠ΅ Π²ΠΈΠ²ΡΠ΅Π½Π° ΡΠΎΠ»Ρ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ»ΡΡ
Ρ RANK-RANKL-OPG ΠΏΡΠΈ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌΡ ΠΌΠΎΠ΄Π΅Π»ΡΠ²Π°Π½Π½Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡ Π½ΠΈΡΠΎΠΊ, Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΠΉΠΎΠ³ΠΎ Π°ΠΊΡΠΈΠ²Π°ΡΡΡ ΡΠ° Π½Π°ΡΠ²Π½ΡΡΡΡ Π²Π·Π°ΡΠΌΠΎΠ·Π²'ΡΠ·ΠΊΡ Π· ΠΏΡΠΎ- ΡΠ° ΠΏΡΠΎΡΠΈΠ·Π°ΠΏΠ°Π»ΡΠ½ΠΈΠΌΠΈ ΡΠΈΡΠΎΠΊΡΠ½Π°ΠΌΠΈ, Ρ ΡΠΎΠΌΡ ΡΠΈΡΠ»Ρ ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½Π° ΠΊΠΎΡΠ΅Π»ΡΡΡΡ ΠΌΡΠΆ RANKL Ρ ΠΏΡΠΎΡΡΠ±ΡΠΎΡΠΈΡΠ½ΠΈΠΌ TGF-Ξ²1 (r = 0,61). ΠΠΈΡΠ²Π»Π΅Π½Ρ Π½ΠΎΠ²Ρ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ½Ρ ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠΈ ΠΏΠΎΡΡΡΠ΅Π½Π½Ρ ΡΡΠ°Π½Ρ ΠΊΡΡΡΠΊΠΎΠ²ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ, ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΡΡΠ±ΡΠΎΠ·Ρ ΠΏΠ΅ΡΡΠ½ΠΊΠΈ ΡΠ° ΠΏΡΠ΄ΡΠ»ΡΠ½ΠΊΠΎΠ²ΠΎΡ Π·Π°Π»ΠΎΠ·ΠΈ, ΠΏΠΎΠ²'ΡΠ·Π°Π½Ρ Π·Ρ Π·Π½ΠΈΠΆΠ΅Π½Π½ΡΠΌ ΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΡΠ². ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠΈ Π³Π΅ΠΌΠΎΡΡΠ°Π·Ρ Π²ΠΏΠ»ΠΈΠ²Π°ΡΡΡ Π½Π° Π°ΠΊΡΠΈΠ²Π°ΡΡΡ ΠΏΡΠΎΠ»ΡΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² Ρ ΡΠΏΠΎΠ»ΡΡΠ½ΡΠΉ ΡΠΊΠ°Π½ΠΈΠ½Ρ. ΠΠΎΠΆΠ»ΠΈΠ²ΡΡΡΡ ΠΏΠ΅ΡΠ΅Π½Π΅ΡΠ΅Π½Π½Ρ ΠΎΡΡΠΈΠΌΠ°Π½ΠΈΡ
Π΄Π°Π½ΠΈΡ
Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ Π»ΡΠ΄ΠΈΠ½ΠΈ ΡΡΠΎΡΠ½ΡΠ²Π°Π»Π°ΡΡ Π½Π° ΠΊΠ»ΡΠ½ΡΡΠ½ΠΎΠΌΡ ΠΌΠ°ΡΠ΅ΡΡΠ°Π»Ρ. ΠΠΈΡΠ²Π»Π΅Π½Π° ΡΠΎΠ»Ρ ΡΡΠ°Π½Ρ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ Ρ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΡΡΠΊΠ»Π°Π΄Π½Π΅Π½Ρ Ρ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΡΠ² Ρ Ρ
Π²ΠΎΡΠΈΡ
Π· Π³ΡΠ΄ΡΠΎΠ½Π΅ΡΡΠΎΡΠΈΡΠ½ΠΎΡ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΡΡΡ Π½ΠΈΡΠΎΠΊ, Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π°ΠΊΡΠΈΠ²Π°ΡΡΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ»ΡΡ
Ρ RANK-RANKL-OPG Ρ Ρ
Π²ΠΎΡΠΈΡ
Π½Π° Π³ΡΠ΄ΡΠΎΠ½Π΅ΡΡΠΎΠ·. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ ΡΡΠ·Π½ΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΡΠ² ΡΠ΅Π³ΡΠ»ΡΡΡΡ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ ΠΏΡΠΈ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡ ΠΎΡΠ³Π°Π½ΡΠ² ΠΏΠ°Π½ΠΊΡΠ΅Π°ΡΠΎΠ΄ΡΠΎΠ΄Π΅Π½Π°Π»ΡΠ½ΠΎΡ Π·ΠΎΠ½ΠΈ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Ρ ΠΎΡΡΠ½ΠΊΠΈ ΡΡΠ°Π½Ρ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ Π·Π°ΠΏΡΠΎΠΏΠΎΠ½ΠΎΠ²Π°Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΡΠ²Π°Π½Π½Ρ Ρ
ΡΡΡΡΠ³ΡΡΠ½ΠΈΡ
ΡΡΠΊΠ»Π°Π΄Π½Π΅Π½Ρ ΡΠ° ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΡΠ² Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Π½Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΉ ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΡΠ· ΠΎΡΡΠΈΠΌΠ°Π½ΠΈΡ
Π΄Π°Π½ΠΈΡ
, Π½Π° ΠΎΡΠ½ΠΎΠ²Ρ ΡΠΊΠΎΠ³ΠΎ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΡΠ°ΠΊΡΠΎΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΡΠ·Ρ Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½Ρ Π³ΡΡΠΏΠΈ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΡΠ² (ΡΠ°ΠΊΡΠΎΡΡΠ²), ΡΠΊΡ Π²ΡΠ΄ΠΎΠ±ΡΠ°ΠΆΠ°ΡΡΡ ΠΎΡΠ½ΠΎΠ²Π½Ρ Π½Π°ΠΏΡΡΠΌΠΊΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ, ΠΎΠΏΠΎΡΠ΅ΡΠ΅Π΄ΠΊΠΎΠ²Π°Π½Ρ ΡΠ΅Π°ΠΊΡΡΡΡ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ. ΠΠΎΠΏΠΎΠ²Π½Π΅Π½Ρ Π½Π°ΡΠΊΠΎΠ²Ρ Π΄Π°Π½Ρ ΠΏΡΠΎ ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠΈ Ρ
ΡΠΎΠ½ΡΠ·Π°ΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ ΠΏΡΠΈ Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Π½ΡΡ
Π½ΠΈΡΠΎΠΊ, ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ Π·ΠΌΡΠ½ΠΈ ΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½Ρ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ ΠΌΠΎΠΆΡΡΡ Π±ΡΡΠΈ ΠΊΡΠ»ΡΠΊΡΡΠ½ΠΎ Π·Π°ΡΡΠΊΡΠΎΠ²Π°Π½Ρ Π½Π°Π²ΡΡΡ Ρ ΡΠ°Π·Ρ ΡΠΏΠΎΠ²ΡΠ»ΡΠ½Π΅Π½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡ Π² Π½Π΅Π²Π΅Π»ΠΈΠΊΠΎΠΌΡ Π·Π° ΠΌΠ°ΡΠΎΡ ΠΎΡΠ³Π°Π½Ρ. ΠΠΎΠΏΠΎΠ²Π½Π΅Π½Ρ Π½Π°ΡΠΊΠΎΠ²Ρ Π΄Π°Π½Ρ ΠΏΡΠΎ ΡΠΎΠ»Ρ ΡΠ° ΡΡΡΠΏΡΠ½Ρ Π·Π°Π»ΡΡΠ΅Π½ΠΎΡΡΡ ΠΏΠΎΡΡΡΠ΅Π½Ρ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΡ ΡΡΠ½ΠΊΡΡΡ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ Ρ ΡΠΎΠ·Π²ΠΈΡΠΎΠΊ Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½Ρ ΡΠ»ΡΠ½ΠΊΠΎΠ²ΠΎ-ΠΊΠΈΡΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΡ, Π² ΡΠΎΠΌΡ ΡΠΈΡΠ»Ρ Π΄ΡΠΎΠ΄Π΅Π½Π°Π»ΡΠ½ΠΎΡ Π²ΠΈΡΠ°Π·ΠΊΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½Π° ΡΠΎΠ»Ρ Ρ Π·Π½Π°ΡΠ΅Π½Π½Ρ Π·Π½ΠΈΠΆΠ΅Π½Π½Ρ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΡΠ΅Π·Π΅ΡΠ²ΡΠ² ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ Π΄Π»Ρ Π·Π±ΡΠ»ΡΡΠ΅Π½Π½Ρ ΡΠΈΠ·ΠΈΠΊΡΠ² Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½ΠΎΡΡΡ Π² ΠΏΠΎΠΏΡΠ»ΡΡΡΡ. ΠΠ°ΠΏΡΠΎΠΏΠΎΠ½ΠΎΠ²Π°Π½ΠΎ ΠΌΠ΅ΡΠΎΠ΄ ΠΎΡΡΠ½ΠΊΠΈ ΡΠΈΠ·ΠΈΠΊΡΠ² Π΄Π»Ρ ΠΏΠΎΠΏΡΠ»ΡΡΡΠΉΠ½ΠΎΠ³ΠΎ Π·Π΄ΠΎΡΠΎΠ²'Ρ Π½Π°ΡΠ΅Π»Π΅Π½Π½Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Ρ Π°Π½Π°Π»ΡΠ·Ρ ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΡΠ΅Π·Π΅ΡΠ²ΡΠ² ΡΡΠ·ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ ΡΠΏΠΎΠ»ΡΡΠ½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ.ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ β ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΠΎΠ»ΠΈ ΡΡΠ΅ΡΠ΅ΠΎΡΠΈΠΏΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΊΠ°ΠΊ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΠ·ΡΡΠ°Π»ΠΈΡΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΌΠ΅Π΄ΠΈΠ°ΡΠΎΡΠΎΠ² ΠΈ Π΄ΡΡΠ³ΠΈΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠ°ΡΠ΅Π½Ρ
ΠΈΠΌΠ°ΡΠΎΠ·Π½ΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² (ΠΏΠΎΡΠΊΠΈ, ΠΏΠ΅ΡΠ΅Π½Ρ, ΠΏΠΎΠ΄ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½Π°Ρ ΠΆΠ΅Π»Π΅Π·Π°) ΠΈ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠ° ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΡΡΠΎΡΠ½ΡΠ»Π°ΡΡ Π½Π° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠΎΡΠ΅ΠΊ Π½Π°ΡΡΡΠ°ΡΡΡΡ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΡΡΡΡ ΡΠΈΡΠΎΠΊΠΈΠ½Π°ΠΌΠΈ, ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°ΡΡΡΡ ΡΡΠΎΠ²Π½ΠΈ Π°Π΄ΠΈΠΏΠΎΠΊΠΈΠ½ΠΎΠ², Π°ΠΊΡΠΈΠ²ΠΈΡΡΠ΅ΡΡΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΠ΅ Π·Π²Π΅Π½ΠΎ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ β ΠΏΡΡΡ RANKRANKL-OPG, ΠΈΠΌΠ΅Π΅Ρ ΠΌΠ΅ΡΡΠΎ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ RANKL ΠΈ Π²ΠΈΡΡΠ°ΡΠΈΠ½ΠΎΠΌ (r = 0,48), ΠΏΡΠΎΡΠΈΠ±ΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΌ TGF-Ξ²1 ΠΈ Π°Π΄ΠΈΠΏΠΎΠ½Π΅ΠΊΡΠΈΠ½ΠΎΠΌ (r = 0,47). ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΏΠ°Π½ΠΊΡΠ΅Π°ΡΠΎΠ΄ΡΠΎΠ΄Π΅Π½Π°Π»ΡΠ½ΠΎΠΉ Π·ΠΎΠ½Ρ ΠΈ ΡΠΈΠ±ΡΠΎΠ·Π° ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π΄Π΅ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎ-Π΄ΠΈΡΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ, Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ
Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠΈ ΠΎΠΊΡΠΈΠΏΡΠΎΠ»ΠΈΠ½Π° Ρ ΠΌΠΎΡΠΎΠΉ Π·Π° ΡΡΠ΅Ρ ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠΈ. ΠΠ°ΡΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΈ Π²ΡΡ
ΠΎΠ΄ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π½Π° ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Ρ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ°ΠΌΠΈ. ΠΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠ΅Π°Π»ΠΈΠ·ΡΠ΅ΡΡΡ ΡΠ΅ΡΠ΅Π· ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΠΈΠΌΠ΅ΡΡ ΡΠ΅ΡΠ½ΡΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π·Π²Π΅Π½Π° Π³Π΅ΠΌΠΎΡΡΠ°Π·Π°. ΠΡΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΏΠ°Π½ΠΊΡΠ΅Π°ΡΠΎΠ΄ΡΠΎΠ΄Π΅Π½Π°Π»ΡΠ½ΠΎΠΉ Π·ΠΎΠ½Ρ ΠΈ ΡΠΈΠ±ΡΠΎΠ·Π° ΠΏΠ΅ΡΠ΅Π½ΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π³Π΅ΠΌΠΎΡΡΠ°Π·Π° Π²Π»ΠΈΡΡΡ Π½Π° Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, ΡΡΠΎ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ². Π Π³ΡΡΠΏΠΏΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π³ΠΈΠ΄ΡΠΎΠ½Π΅ΡΡΠΎΠ·ΠΎΠΌ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΏΡΡΠΈ RANK-RANKL-OPG, ΡΡΠΎ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ. ΠΡΠ½ΠΎΠ²ΠΎΠΉ ΡΡΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² β IL-1RA, IL-17 ΠΈ Π²ΠΈΡΡΠ°ΡΠΈΠ½Π°, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄ΠΈΡΠ±Π°Π»Π°Π½Ρ (ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ) ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΎΠ²Π½ΡΠΌΠΈ TGF-Ξ²1 ΠΈ Π°Π΄ΠΈΠΏΠΎΠ½Π΅ΠΊΡΠΈΠ½Π° (r = - 0,29). Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ ΠΏΠ°Π½ΠΊΡΠ΅Π°ΡΠΎΠ΄ΡΠΎΠ΄Π΅Π½Π°Π»ΡΠ½ΠΎΠΉ Π·ΠΎΠ½Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΈ ΡΡΠΆΠ΅ΡΡΡ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π·Π°Π²ΠΈΡΡΡ ΠΎΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π΄ΠΈΡΠ±Π°Π»Π°Π½ΡΠ° ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ»Ρ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π·Π°ΡΠΈΡΡ. Π Π°Π·Π²ΠΈΡΠΈΠ΅ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠΈ Π½Π° ΡΠΎΠ½Π΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΡΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ Π² ΠΊΡΠΎΠ²ΠΈ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π°ΡΠΈΠΏΠΈΡΠ½ΡΠΌ ΡΠΎΡΠΌΠ°ΠΌ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π°, ΡΡΠΎ ΠΌΠΎΠΆΠ΅Ρ Π²Π΅ΡΡΠΈ ΠΊ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΈ ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π°Π½Π½ΡΡ
ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΡΡΠΈ Π³ΡΡΠΏΠΏΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΡ
ΡΡΠ΅ΡΠ΅ΠΎΡΠΈΠΏΠ½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ. ΠΡΡΠΏΠΏΠ° 1 β ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΠ΅Ρ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°ΠΌ, ΠΊΠΎΡΠΎΡΡΠ΅ Π΄Π΅ΠΉΡΡΠ²ΡΡΡ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π² ΡΠ΅Π»ΠΎΠΌ. Π‘ΡΡΠ² ΡΡΠΈΡ
Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π²Π΅Π΄Π΅Ρ ΠΊ Ρ
ΡΠΎΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΈ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΎΠ². Π Π½Π΅ΠΉ ΠΎΡΠ½ΠΎΡΡΡΡΡ ΡΡΠΎΠ²Π½ΠΈ Π²ΠΈΡΡΠ°ΡΠΈΠ½Π°, IL-4, IL-6, TGF-Ξ²1, ΠΌΠ°ΡΡΠ° ΠΈ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΡΠΈ, ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ Π°Π³ΡΠ΅Π³Π°ΡΠΈΠΈ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΈΠ½Π΄ΡΠΊΡΠΎΡΠ° 10 ΠΌΠΊΠΌΠΎΠ»Ρ/Π», ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ²Π»ΡΡΡΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠΌΠΈ ΠΏΠΎΡΡΠ΅Π΄Π½ΠΈΠΊΠ°ΠΌΠΈ ΡΡΡΠ²Π° Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ. ΠΡΡΠΏΠΏΠ° 2 β ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΠ΅Ρ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΎΡΠ½ΡΠΌ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°ΠΌ, Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠΈΠΌ Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΏΡΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π·Π΅ΡΠ²ΠΎΠ², ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠ΅ Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½ΠΎ, Π° Π½Π° ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅ β ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΎ. Π Π½Π΅Π΅ Π²Ρ
ΠΎΠ΄ΡΡ: ΡΡΠΎΠ²Π½ΠΈ IL-1, IL-1RA, RANKL, ΠΊΠ°Π»ΡΡΠΈΡΠΎΠ½ΠΈΠ½Π° ΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ Π°Π³ΡΠ΅Π³Π°ΡΠΈΠΈ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
ΠΈΠ½Π΄ΡΠΊΡΠΎΡΠ° 2,5 ΠΈ 10 ΠΌΠΊΠΌΠΎΠ»Ρ/Π». ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π³ΡΡΠΏΠΏΡ 2 ΡΠ²Π»ΡΡΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌΠΈ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π² Ρ
ΠΎΠ΄Π΅ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΡΡΠΏΠΏΠ° 3 β ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΠ΅Ρ ΡΠ΅Π·ΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΎΠ±ΠΌΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π½Π° ΡΡΠΎΠ²Π½Π΅ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΡΡ
Π·Π°Π΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°Π½ΠΎ Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΠΏΡΡΠ΅ΠΉ ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΡΠΎ ΡΠΌΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π² ΡΡΠΎΡΠΎΠ½Ρ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΡ ΡΠΈΠ½ΡΠ΅Π·Π° Π½Π°Π΄ ΡΠ°ΡΠΏΠ°Π΄ΠΎΠΌ. ΠΡΡΠΏΠΏΠ° 3 ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½ΡΠ΅Ρ ΡΡΠΎΠ²Π½ΠΈ IL-17, OPG, RANKL, Π°Π΄ΠΈΠΏΠΎΠ½Π΅ΠΊΡΠΈΠ½Π°, ΠΏΠ°ΡΠ°ΡΠΈΡΠ΅ΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ Π³ΠΎΡΠΌΠΎΠ½Π°, Π²ΡΠ΅Ρ
ΡΡΠ°ΠΊΡΠΈΠΉ ΠΎΠΊΡΠΈΠΏΡΠΎΠ»ΠΈΠ½Π° ΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π°Π³ΡΠ΅Π³Π°ΡΠΈΠΈ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ² ΠΏΡΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
ΠΈΠ½Π΄ΡΠΊΡΠΎΡΠ° 2,5 ΠΈ 5 ΠΌΠΊΠΌΠΎΠ»Ρ/Π». ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΡΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½Ρ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½Π½ΠΎΡΡΠΈ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π² ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠ΅ΡΡ Π½Π° ΡΠ°Π½Π½ΠΈΡ
ΡΡΠ°Π΄ΠΈΡΡ
Π΅Π³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ, Π²ΠΊΠ»ΡΡΠ°Ρ Π΄ΠΎΠ½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ. ΠΡΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ΅ΠΌΠ°Ρ
ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»ΡΠ΅ΡΡΡ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Π² ΡΠ΅Π»ΠΎΠΌ, ΡΠΎ Π΅ΡΡΡ Π΅Π΅ ΡΠ΅Π°ΠΊΡΠΈΡ Π½Π°ΡΡΠ΄Ρ Ρ ΡΠ΅Π°ΠΊΡΠΈΡΠΌΠΈ Π΄ΡΡΠ³ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΈ ΡΠΈΡΡΠ΅ΠΌ ΠΏΡΠΈ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· Π²Π°ΠΆΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° (SIRS). Π Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΈΠ·ΠΌΠ΅Π½ΡΠ΅ΡΡΡ Ρ
ΠΎΠ΄ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈ ΡΡΠ΅ΠΏΠ΅Π½Ρ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, ΡΡΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΆΠ½ΡΠΌ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ Ρ
ΡΠΎΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΡΠΈΡΠΊΠ° ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅Π½Π½ΠΎΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π΅Ρ ΠΎΠ±ΠΌΠ΅Π½Π° (ΠΎΠΊΡΠΈΠΏΡΠΎΠ»ΠΈΠ½Π° ΠΈ Π³Π»ΠΈΠΊΠΎΠ·Π°ΠΌΠΈΠ½ΠΎΠ³Π»ΠΈΠΊΠ°Π½ΠΎΠ²) Π΄Π»Ρ ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π½Π΅ΡΡΠΎΡΠΊΠ»Π΅ΡΠΎΠ·Π° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠΎΠΌ, ΡΠ΅Π½Π°Π»ΡΠ½ΠΎΠΉ ΠΎΡΡΠ΅ΠΎΠ΄ΠΈΡΡΡΠΎΡΠΈΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΡΠ΅ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ, ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠ°Π·Π½ΠΎΠΉ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΠΆΠ΅Π»ΡΠ΄ΠΊΠ΅; ΡΠΎΠ»Ρ ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΌΠ΅Π΄ΠΈΠ°ΡΠΎΡΠΎΠ² Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ΅ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ Ρ ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ² Ρ Π΄ΡΠΎΠ΄Π΅Π½Π°Π»ΡΠ½ΠΎΠΉ ΡΠ·Π²ΠΎΠΉ, Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΊΠ°ΡΠ΄ΠΈΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ ΠΈ ΠΎΡΡΠ΅ΠΎΠΏΠ΅Π½ΠΈΠ΅ΠΉ Π½Π° ΡΠΎΠ½Π΅ Π½Π΅Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π΄ΠΈΡΠΏΠ»Π°Π·ΠΈΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΎΠΊΡΠΈΠΏΡΠΎΠ»ΠΈΠ½Π°, Π³Π»ΠΈΠΊΠΎΠ·Π°ΠΌΠΈΠ½ΠΎΠ³Π»ΠΈΠΊΠ°Π½ΠΎΠ² ΠΈ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π°ΡΠΈΠΏΠΈΡΠ½ΡΠΌ ΡΠΎΡΠΌΠ°ΠΌ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π΄ΠΎΠ½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ ΠΈ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΡ.Dissertation is devoted to solving the urgent problem of establishing the role of the stereotypical reactions of connective tissue as a physiological system in the development of the pathological processes. General principles for the assessment of the physiological system of connective tissue are formulated, and its role in the development of the pathological processes in the parenchymatous organs (kidney, liver, pancreas) and bone is determined. We first studied the role of regulatory path RANK-RANKL-OPG in experimental modeling of renal diseases, its activation and the relationship with pro- and anti-inflammatory cytokines, including a positive correlation between RANKL and profibrogenic TGF-Ξ²1 (r = 0,61). New pathogenetic mechanisms of disturbances of condition of bone tissue are identified and development of fibrosis of the liver and pancreas, associated with a decrease in the functional activity of platelets is made. It is established that the hemostasis mechanisms influence the activation of proliferative processes in the connective tissue. Possibility of transferring the data on the person was specified on the clinical material. Role of the state of the physiological system of connective tissue in the development of complications and recurrences in patients with hydronephrotic transformation of the kidneys is detected; activation regulatory path RANKRANKL-OPG in patients with hydronephrosis is established. Interrelation of the various mechanisms of regulation of the physiological system of connective tissue in the development of pathology of the pancreatoduodenal zonesβ organs is shown. Based on the assessment of the physiological system of connective tissue the methods for predicting surgical complications and recurrence of the disease are proposed. Conducted meta-analysis of the obtained data, on the basis of which with the help of factor analysis, the main groups of indicators (factors) are established, which reflect the main directions of the pathological process, mediated reactions in physiological system of the connective tissue. Augmented scientific data on the mechanisms of chronization of the pathological process in diseases of the kidneys is supplemented; it is shown that changes of the functional state of the connective tissue can be quantitatively recorded even in the case of a sluggish pathological process in the small mass organ. Augmented scientific data on the role and degree of involvement of the regulatory function damages of the physiological system of connective tissue in the development of diseases of the gastrointestinal tract, including duodenal ulcer is supplemented. Role and significance of the decline in physiological reserves of the physiological system of connective tissue to increase the risk of morbidity in the population is shown. Method of risk assessment for population health based on the analysis of physiological reserves of the physiological system of the connective tissue is proposed
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