幼児期における多義図形認知の発達--表象発達からのアプローチ

愛知県立大学2016年

貧困が子どもの発達に及ぼす影響に関する一考察\n―子どもの人間関係に着目して―

In light of the current situation regarding poverty in Japan, this paper examines how poverty affects child development and how everyday life experiences during infancy should be guaranteed in order to correct the effects of poverty. Currently, Japanese citizens are beginning to become aware that there is an issue in that Japan is a poor society. If the child poverty issue is considered from the viewpoint of child development, social exclusion is considered to be an issue. Important development during infancy is impeded as a result of being unable to participate in society owing to poverty, and being excluded from interactions with others. Poverty measures for children also require economic support for children\u27s everyday lives so that they will not be subjected to social exclusion. As support at childcare centers, etc., relationship building for guardians is necessary in order not to exclude the children\u27s guardians from social networks. This paper also considers the fact that for children, it is important to guarantee development during infancy sufficiently

保育内容「人間関係」指導法に関する一考察 ―子どもの姿を想像することと受講生の理解度との関連―

The purpose of this research is to propose classes that will foster students\u27 ability to imagine what children are like. In March 2017, Course of study for kindergarten and Guidelines for Nursery Care at Day Nursery were announced, the ‘qualities and abilities that you want to foster’ and the ‘the kinds of people you want the children to grow up to be by the end of childhood’ were presented, and emphasis was placed on the processes for linking them (conceptual ability pertaining to nursery care and practical ability pertaining to nursery care). However, as students find it difficult to imagine what children are like, it was predicted that understanding the content of the classes will also be difficult. In particular, with regard to the area of ‘Human relationships’, as qualities and abilities are obtained through interacting with people, it was predicted that it would be effective to experience how children change as a result of interacting with people, while actually spending time with children and empathizing and communicating with them. This research discusses methods for understanding lesson content through one\u27s own experiences, that is, through having experienced a variety of ways that children can be

RUNX3 Has an Oncogenic Role

Background: Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of cancer and appears to be an important component of the transforming growth factor-beta (TGF-ß)-induced tumor suppression pathway. Surprisingly, we found that RUNX3 expression level in head and neck squamous cell carcinoma (HNSCC) tissues, which is one of the most common types of human cancer, was higher than that in normal tissues by a previously published microarray dataset in our preliminary study. Therefore, here we examined the oncogenic role of RUNX3 in HNSCC. Principal Findings: Frequent RUNX3 expression and its correlation with malignant behavior were observed in HNSCC. Ectopic RUNX3 overexpression promoted cell growth and inhibited serum starvation-induced apoptosis and chemotherapeutic drug induced apoptosis in HNSCC cells. These findings were confirmed by RUNX3 knockdown. Moreover, RUNX3 overexpression enhanced tumorsphere formation. RUNX3 expression level was well correlated with the methylation status in HNSCC cells. Moreover, RUNX3 expression was low due to the methylation of its promoter in normal oral epithelial cells. Conclusions/Significance: Our findings suggest that i) RUNX3 has an oncogenic role in HNSCC, ii) RUNX3 expression observed in HNSCC may be caused in part by demethylation during cancer development, and iii) RUNX3 expression can be a useful marker for predicting malignant behavior and the effect of chemotherapeutic drugs in HNSCC

RUNX3 Has an Oncogenic Role in Head and Neck Cancer

Background: Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of cancer and appears to be an important component of the transforming growth factor-beta (TGF-ß)-induced tumor suppression pathway. Surprisingly, we found that RUNX3 expression level in head and neck squamous cell carcinoma (HNSCC) tissues, which is one of the most common types of human cancer, was higher than that in normal tissues by a previously published microarray dataset in our preliminary study. Therefore, here we examined the oncogenic role of RUNX3 in HNSCC. Principal Findings: Frequent RUNX3 expression and its correlation with malignant behavior were observed in HNSCC. Ectopic RUNX3 overexpression promoted cell growth and inhibited serum starvation-induced apoptosis and chemotherapeutic drug induced apoptosis in HNSCC cells. These findings were confirmed by RUNX3 knockdown. Moreover, RUNX3 overexpression enhanced tumorsphere formation. RUNX3 expression level was well correlated with the methylation status in HNSCC cells. Moreover, RUNX3 expression was low due to the methylation of its promoter in normal oral epithelial cells. Conclusions/Significance: Our findings suggest that i) RUNX3 has an oncogenic role in HNSCC, ii) RUNX3 expression observed in HNSCC may be caused in part by demethylation during cancer development, and iii) RUNX3 expression can b