Roles of the Bloom's syndrome helicase in the maintenance of genome stability

The RecQ family of DNA helicases is highly conserved in evolution from bacteria to humans. Of the five known human RecQ family members, three (BLM, WRN and RECQ4, which cause Bloom's syndrome, Werner's syndrome and Rothmund-Thomson syndrome respectively) are mutated in distinct clinical disorders associated with cancer predisposition and/or premature aging. BLM forms part of a multienzyme complex including topoisomerase IIIalpha, replication protein A and a newly identified factor called BLAP75. Together, these proteins play a role in the resolution of DNA structures that arise during the process of homologous recombination repair. In the absence of BLM, cells show genomic instability and a high incidence of sister-chromatid exchanges. In addition to a DNA structure-specific helicase activity, BLM also catalyses Holliday-junction branch migration and the annealing of complementary single-stranded DNA molecules

“When that understanding is there, you work much better together”: the role of family in audiological rehabilitation for older adults

OBJECTIVE: This study aimed to explore the experiences and perceptions of adults with hearing impairment and family members regarding the role of family in audiological rehabilitation. DESIGN: A qualitative descriptive methodology was used. STUDY SAMPLE: A total of 37 people participated, 24 older adults with hearing impairment and 13 family members (11 spouses and 2 adult children). Four focus group interviews were conducted with the adults with hearing impairment, and 3 with family members. RESULTS: Five key themes emerged from analysis of the transcripts: (1) knowledge and understanding of hearing impairment and treatment; (2) the role of family members in rehabilitation is complex and multifaceted; (3) audiologists have an influential role in facilitating family member involvement; (4) the role of communication in rehabilitation; and (5) outcomes of family member involvement. Importantly, although perceptions were generally very positive, there was some uncertainty about the role of family. CONCLUSIONS: Audiologists have a key role in facilitating family involvement in audiological rehabilitation that is identified by adults with hearing impairment and their families. Although participants reported limited involvement in audiological rehabilitation currently, they identified potential for involvement in areas such as goal setting and decision-making

Impact of Sodium Layer variations on the performance of the E-ELT MCAO module

Multi-Conjugate Adaptive Optics systems based on sodium Laser Guide Stars may exploit Natural Guide Stars to solve intrinsic limitations of artificial beacons (tip-tilt indetermination and anisoplanatism) and to mitigate the impact of the sodium layer structure and variability. The sodium layer may also have transverse structures leading to differential effects among Laser Guide Stars. Starting from the analysis of the input perturbations related to the Sodium Layer variability, modeled directly on measured sodium layer profiles, we analyze, through a simplified end-to-end simulation code, the impact of the low/medium orders induced on global performance of the European Extremely Large Telescope Multi-Conjugate Adaptive Optics module MAORY.Comment: 7 pages, 5 figures, SPIE conference Proceedin

"It's Huge, in a Way." Conflicting Stakeholder Priorities for Managing Hearing Impairment for People Living with Dementia in Residential Aged Care Facilities

Objectives: The aims of this study were to a) explore the impact of hearing impairment on people living with dementia in residential aged care facilities (RACFs) and b) investigate management of hearing impairment for this population. / Methods: A descriptive qualitative approach, consisting of semi-structured interviews, was conducted with 23 participants across four stakeholder groups (audiologists, care staff, family members and individuals with dementia and hearing impairment living in RACFs). / Results: Thematic analysis revealed an overarching theme of “different priorities for managing hearing impairment” that emerged from the data. Audiologists and care staff prioritized different practices for managing hearing impairment: audiologists emphasized hearing aids and care staff emphasized communication strategies. Care staff also identified that current management of hearing impairment was sub-optimal as they do not prioritize managing it. / Conclusions: Residents with dementia and hearing impairment living in RACFs are not receiving optimal hearing management. Further research is required to understand the factors that influence this

Discrimination of hot versus cold avalanche deposits: Implications for hazard assessment at Mount Meager, B.C.

The surficial deposits surrounding the Mount Meager volcanic complex include numerous avalanche deposits. These deposits share many attributes: (a) they are nearly monolithologic and comprise mainly intermediate volcanic rock clasts, (b) they lack internal structure, and (c) they are very poorly sorted. Despite these similarities, the avalanche deposits represent two distinct processes. Mass wasting of the Mount Meager volcanic edifice has produced cold rock avalanche deposits, whereas gravitational collapse of active lava domes and flows has produced hot block and ash avalanche deposits. The ability to discriminate between these "hot" and "cold" avalanche deposits is a critical component in the assessment of hazards in volcanic terranes. Hot block and ash avalanche deposits can be distinguished by the presence of radially-oriented joints, breadcrust textures, and incipient welding, which are features indicative of high emplacement temperatures. Conversely, rock avalanche deposits resulting from mass wasting events may be distinguished by the presence of clasts that preserve pre-depositional weathering and jointing surfaces. Volcanic avalanches are mechanically similar to rock avalanches but pose a greater hazard due to high temperatures, increased fluidization from degassing and the potential to decouple highly mobile elutriated ash clouds. The increasing use of hazardous regions such as the Lillooet River valley requires more reliable risk assessment in order to minimize losses from future hazardous events

The growing challenge: a strategic review of HIV social care, support and information services across the UK

No abstract available

The nutritional care of people living with dementia at home: A scoping review.

There are an increasing number of people with dementia living in their own home for longer, often supported by a family member. The symptoms of dementia can affect an individual's nutritional status, which can lead to a reduced quality of life for the person with dementia and their family members. A scoping review was conducted from July 2016 until September 2016, using a recognised framework, to explore what is currently known, and identify any gaps in the research regarding the nutritional care of people living with dementia at home. This included any interventions that may have been trialled or implemented, and the views of those living with dementia, carers and clinicians. Six electronic databases were searched from inception to July 2016. A review team was involved in screening and data extraction for selected articles. Published qualitative and quantitative studies were included that explored the nutritional care of people living with dementia at home. Methods included data extraction and conventional content analysis. Stakeholders were involved in the development of final categories. Following screening, 61 studies reported in 63 articles were included. Most studies were cross-sectional (n = 24), cohort (n = 15) or qualitative (n = 9). Only three were randomised controlled trials. Three overarching categories represented the results: Timely identification of nutritional risk and subsequent regular monitoring of nutritional status, multi-component tailored interventions and the influence of the care-giving dyad on nutritional status. Many studies identify people living at home with dementia as a vulnerable group prone to malnutrition; however, a lack of interventions exists to address the increased risk. There is a lack of research exploring the role of home care providers and healthcare professionals in the provision of nutritional care. Further research is required to explore how the emotional aspect of the care-giving dyad influences nutritional care

Dynamical effects of interactions and the Tully-Fisher relation for Hickson compact groups

We investigate the properties of the B-band Tully-Fisher (T-F) relation for 25 compact group galaxies, using Vmax derived from 2-D velocity maps. Our main result is that the majority of the Hickson Compact Group galaxies lie on the T-F relation. However, about 20% of the galaxies, including the lowest-mass systems, have higher B luminosities for a given mass, or alternatively, a mass which is too low for their luminosities. We favour a scenario in which outliers have been brightened due to either enhanced star formation or merging. Alternatively, the T-F outliers may have undergone truncation of their dark halo due to interactions. It is possible that in some cases, both effects contribute. The fact that the B-band T-F relation is similar for compact group and field galaxies tells us that these galaxies show common mass-to-size relations and that the halos of compact group galaxies have not been significantly stripped inside R25. We find that 75% of the compact group galaxies studied (22 out of 29) have highly peculiar velocity fields. Nevertheless, a careful choice of inclination, position angle and center, obtained from the velocity field, and an average of the velocities over a large sector of the galaxy enabled the determination of fairly well-behaved rotation curves for the galaxies. However, two of the compact group galaxies which are the most massive members in M51--like pairs, HCG 91a and HCG 96a, have very asymmetric rotation curves, with one arm rising and the other one falling, indicating, most probably, a recent perturbation by the small close companions.Comment: 15 pages, 4 figures, accepted for publication in the Astronomical Journa

How Can eHealth Meet the Hearing and Communication Needs of Adults With Hearing Impairment and their Significant Others? A Group Concept Mapping Study

Objectives: To seek the perspectives of key stakeholders regarding: (1) how eHealth could help meet the hearing and communication needs of adults with hearing impairment and their significant others; and (2) how helpful each aspect of eHealth would be to key stakeholders personally. / Design: Group concept mapping, a mixed-methods participatory research method, was used to seek the perspectives of key stakeholders: adults with hearing impairment (n = 39), significant others (n = 28), and hearing care professionals (n = 56). All participants completed a short online survey before completing one or more of the following activities: brainstorming, sorting, and rating. Brainstorming required participants to generate ideas in response to the focus prompt, “One way I would like to use information and communication technologies to address the hearing and communication needs of adults with hearing loss and their family and friends is to….” The sorting task required participants to sort all statements into groups that made sense to them. Finally, the rating task required participants to rate each of the statements according to “How helpful would this idea be to you?” using a 5-point Likert scale. Hierarchical cluster analysis was applied to the “sorting” data to develop a cluster map using the Concept Systems software. The “rating” data were subsequently analyzed at a cluster level and an individual-item level using descriptive statistics. Differences in cluster ratings between stakeholder groups were examined using Kruskal-Wallis tests. / Results: Overall, 123 statements were generated by participants in response to the focus prompt and were included in subsequent analyses. Based on the “sorting” data and hierarchical cluster analysis, a seven-cluster map was deemed to be the best representation of the data. Three key themes emerged from the data, including using eHealth to (1) Educate and Involve Others; (2) Support Aural Rehabilitation; and (3) Educate About and Demonstrate the Impacts of Hearing Impairment and Benefits of Hearing Rehabilitation. Overall median rating scores for each cluster ranged from 3.97 (educate and involve significant others) to 3.44 (empower adults with hearing impairment to manage their hearing impairment from home). / Conclusions: These research findings demonstrate the broad range of clinical applications of eHealth that have the capacity to support the implementation of patient- and family-centered hearing care, with self-directed educational tools and resources typically being rated as most helpful. Therefore, eHealth appears to be a viable option for enabling a more biopsychosocial approach to hearing healthcare and educating and involving significant others in the hearing rehabilitation process without adding more pressure on clinical time. More research is needed to inform the subsequent development of eHealth interventions, and it is recommended that health behavior change theory be adhered to for such interventions