3,864 research outputs found

    International Partnerships: A Model for Educational Organizations

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    Opportunities exist for faculty and students within educational leadership preparation programs to participate in international initiatives within developing countries. One way to do this is through collaboration with organizations that already have an established presence in the country. Working within these organizations provides opportunities for learning and research for the educational leadership program. If done well, such work also helps host organizations meet their mission and goals. An understanding of effective behaviors in international partnerships may benefit educational leadership programs that develop these types of service opportunities. The behaviors mirror the scholar-practitioner philosophy, of which some prominent educational leadership programs adhere, through addressing pragmatic needs within a local context

    Spin-transfer switching and low-field precession in exchange-biased spin valve nano-pillars

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    Using a three-dimensional focused-ion beam lithography process we have fabricated nanopillar devices which show spin transfer torque switching at zero external magnetic fields. Under a small in-plane external bias field, a field-dependent peak in the differential resistance versus current is observed similar to that reported in asymmetrical nanopillar devices. This is interpreted as evidence for the low-field excitation of spin waves which in our case is attributed to a spin-scattering asymmetry enhanced by the IrMn exchange bias layer coupled to a relatively thin CoFe fixed layer.Comment: 11 pages, 4 figures. To appear in APL, April 200

    Lipid Bilayer Composition Affects Transmembrane Protein Orientation and Function

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    Sperm membranes change in structure and composition upon ejaculation to undergo capacitation, a molecular transformation which enables spermatozoa to undergo the acrosome reaction and be capable of fertilization. Changes to the membrane environment including lipid composition, specifically lipid microdomains, may be responsible for enabling capacitation. To study the effect of lipid environment on proteins, liposomes were created using lipids extracted from bull sperm membranes, with or without a protein (Na+ K+-ATPase or α-amylase). Protein incorporation, function, and orientation were determined. Fluorescence resonance energy transfer (FRET) confirmed protein inclusion in the lipid bilayer, and protein function was confirmed using a colourometric assay of phosphate production from ATP cleavage. In the native lipid liposomes, ATPase was oriented with the β subunit facing the outer leaflet, while changing the lipid composition to 50% native lipids and 50% exogenous lipids significantly altered this orientation of Na+ K+-ATPase within the membranes

    Dynamic pinning at a Py/Co interface measured using inductive magnetometry

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    Broadband FMR responses for metallic single-layer and bi-layer magnetic films with total thicknesses smaller than the microwave magnetic skin depth have been studied. Two different types of microwave transducers were used to excite and detect magnetization precession: a narrow coplanar waveguide and a wide microstrip line. Both transducers show efficient excitation of higher-order standing spin wave modes. The ratio of amplitudes of the first standing spin wave to the fundamental resonant mode is independent of frequency for single films. In contrast, we find a strong variation of the amplitudes with frequency for bi-layers and the ratio is strongly dependent on the ordering of layers with respect to a stripline transducer. Most importantly, cavity FMR measurements on the same samples show considerably weaker amplitudes for the standing spin waves. All experimental data are consistent with expected effects due to screening by eddy currents in films with thicknesses below the microwave magnetic skin depth. Finally, conditions for observing eddy current effects in different types of experiments are critically examined

    Exchange anisotropy pinning of a standing spin wave mode

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    Standing spin waves in a thin film are used as sensitive probes of interface pinning induced by an antiferromagnet through exchange anisotropy. Using coplanar waveguide ferromagnetic resonance, pinning of the lowest energy spin wave thickness mode in Ni(80)Fe(20)/Ir(25)Mn(75) exchange biased bilayers was studied for a range of IrMn thicknesses. We show that pinning of the standing mode can be used to amplify, relative to the fundamental resonance, frequency shifts associated with exchange bias. The shifts provide a unique `fingerprint' of the exchange bias and can be interpreted in terms of an effective ferromagnetic film thickness and ferromagnet/antiferromagnet interface anisotropy. Thermal effects are studied for ultra-thin antiferromagnetic Ir(25)Mn(75) thicknesses, and the onset of bias is correlated with changes in the pinning fields. The pinning strength magnitude is found to grow with cooling of the sample, while the effective ferromagnetic film thickness simultaneously decreases. These results suggest that exchange bias involves some deformation of magnetic order in the interface region.Comment: 7 pages, 7 figure

    Genotype imputation for the prediction of genomic breeding values in non-genotyped and low-density genotyped individuals

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    <p>Abstract</p> <p>Background</p> <p>There is wide interest in calculating genomic breeding values (GEBVs) in livestock using dense, genome-wide SNP data. The general framework for genomic selection assumes all individuals are genotyped at high-density, which may not be true in practice. Methods to add additional genotypes for individuals not genotyped at high density have the potential to increase GEBV accuracy with little or no additional cost. In this study a long haplotype library was created using a long range phasing algorithm and used in combination with segregation analysis to impute dense genotypes for non-genotyped dams in the training dataset (S1) and for non-genotyped or low-density genotyped individuals in the prediction dataset (S2), using the 14<sup>th</sup> QTL-MAS Workshop dataset. Alternative low-density scenarios were evaluated for accuracy of imputed genotypes and prediction of GEBVs.</p> <p>Results</p> <p>In S1, females in the training population were not genotyped and prediction individuals were either not genotyped or genotyped at low-density (evenly spaced at 2, 5 or 10 Mb). The proportion of correctly imputed genotypes for training females did not change when genotypes were added for individuals in the prediction set whereas the number of correctly imputed genotypes in the prediction set increased slightly (S1). The S2 scenario assumed the complete training set was genotyped for all SNPs and the prediction set was not genotyped or genotyped at low-density. The number of correctly imputed genotypes increased with genotyping density in the prediction set. Accuracy of genomic breeding values for the prediction set in each scenario were the correlation of GEBVs with true breeding values and were used to evaluate the potential loss in accuracy with reduced genotyping. For both S1 and S2 the GEBV accuracies were similar when the prediction set was not genotyped and increased with the addition of low-density genotypes, with the increase larger for S2 than S1.</p> <p>Conclusions</p> <p>Genotype imputation using a long haplotype library and segregation analysis is promising for application in sparsely-genotyped pedigrees. The results of this study suggest that dense genotypes can be imputed for selection candidates with some loss in genomic breeding value accuracy, but with levels of accuracy higher than traditional BLUP estimated breeding values. Accurate genotype imputation would allow for a single low-density SNP panel to be used across traits.</p
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