57 research outputs found

    Bedaquiline loaded lipid nanoparticles: a promising candidate for TB treatment

    Get PDF
    Four different kinds of Lipid Nanoparticles (LNP) encapsulating bedaquiline have been tested in order to evaluate the possibility to decrease adverse effects of this very efficient and recent antibiotic. The parameters that are studied among these different types of LNP are the surface charge as well as targeting of macrophages through trimannose groups grafted to the surface. It was found that these nanocarriers could encapsulate bedaquiline with a very high loading efficiency, exhibited a very good colloidal stability in storage conditions as well as in biological media, and an excellent compatibility with animal cells. Finally, first in vivo evaluation showed that these carriers are able to accumulate strongly in the lungs and that the almost neutral ones without targeting ligands could be the best candidate for tuberculosis treatment

    Magnetospheric Studies: A Requirement for Addressing Interdisciplinary Mysteries in the Ice Giant Systems

    No full text
    Uranus and Neptune are the least-explored planets in our Solar System. This paper summarizes mysteries about these incredibly intriguing planets and their environments spurred by our limited observations from Voyager 2 and Earth-based systems. Several of these observations are either inconsistent with our current understanding built from exploring other planetary systems, or indicate such unique characteristics of these Ice Giants that they leave us with more questions than answers. This paper specifically focuses on the value of all aspects of magnetospheric measurements, from the radiation belt structure to plasma dynamics to coupling to the solar wind, through a future mission to either of these planets. Such measurements have large interdisciplinary value, as demonstrated by the large number of mysteries discussed in this paper that cover other non-magnetospheric disciplines, including planetary interiors, atmospheres, rings, and moons

    Exploring the Sense-scape of the Gospel of Mark

    No full text
    Copyright © 2011 SAGE PublicationsThis article attempts to address a certain lack of interest in the senses in New Testament Studies by conducting a sensory survey of the Gospel of Mark. Informed by cross-cultural anthropology of the senses, the Gospel of Mark is revealed as an audio-centric text in which hearing is the pre-eminent sense and deafness the gravest sensory impairment. Mark’s ambivalence surrounding the faculty of sight is viewed as a resistance to the pre-eminence of the visual within imperial propaganda
    • …
    corecore