49 research outputs found

    Land-Use Change and Earth System Dynamics: Advancing the Science

    Get PDF
    Quantifying the effects of land-use changes on Earth system dynamics requires adequate information on both past and future land-use activities in a format appropriate for models capable of tracking relevant impacts. This presentation will review past approaches to understanding the role of land-use change on the Earth system dynamics, and summarize new work involving ‘land-use harmonization’ (Hurtt et al. 2009) to advance the understanding for IPCC-AR5 and beyond. Emphasis will be placed on the importance and accuracy of historical maps, uncertainties in future projections, and key challenges for the future

    Behavioral recovery and spinal motoneuron remodeling after polyethylene glycol fusion repair of singly cut and ablated sciatic nerves

    No full text
    Polyethylene glycol repair (PEG-fusion) of severed sciatic axons restores their axoplasmic and membrane continuity, prevents Wallerian degeneration, maintains muscle fiber innervation, and greatly improves recovery of voluntary behaviors. We examined alterations in spinal connectivity and motoneuron dendritic morphology as one potential mechanism for improved behavioral function after PEG-fusion. At 2–112 days after a single-cut or allograft PEG-fusion repair of transected or ablated sciatic nerves, the number, size, location, and morphology of motoneurons projecting to the tibialis anterior muscle were assessed by retrograde labeling. For both lesion types, labeled motoneurons were found in the appropriate original spinal segment, but also in inappropriate segments, indicating mis-pairings of proximal-distal segments of PEG-fused motor axons. Although the number and somal size of motoneurons was unaffected, dendritic distributions were altered, indicating that PEG-fusion preserves spinal motoneurons but reorganizes their connectivity. This spinal reorganization may contribute to the remarkable behavioral recovery seen after PEG-fusion repair
    corecore