Predicting the points of interaction of small molecules in the NF-κB pathway

<p>Abstract</p> <p>Background</p> <p>The similarity property principle has been used extensively in drug discovery to identify small compounds that interact with specific drug targets. Here we show it can be applied to identify the interactions of small molecules within the NF-κB signalling pathway.</p> <p>Results</p> <p>Clusters that contain compounds with a predominant interaction within the pathway were created, which were then used to predict the interaction of compounds not included in the clustering analysis.</p> <p>Conclusions</p> <p>The technique successfully predicted the points of interactions of compounds that are known to interact with the NF-κB pathway. The method was also shown to be successful when compounds for which the interaction points were unknown were included in the clustering analysis.</p

Simulations in Clinics, Contract Drafting, and Upper-Level Courses

I teach in a transactional clinic called the Urban Development Law Clinic. In my Clinic, we represent non-profit tax-exempt organizations that engage in real estate, economic, and community development. Some of our clients include Greater Cleveland Habitat for Humanity and Karamu House, which is a theater and community arts center. We serve as general counsel for some clients and provide legal advice on an as needed basis for others. The Clinic provides legal advice on real estate matters, corporate governance, transactions, and tax issues. The complexity of matters that we handle ranges from drafting a code of regulations to representing clients in large development projects such as a $5.1 million community center for seniors

Simulations in Clinics, Contract Drafting, and Upper-Level Courses

I teach in a transactional clinic called the Urban Development Law Clinic. In my Clinic, we represent non-profit tax-exempt organizations that engage in real estate, economic, and community development. Some of our clients include Greater Cleveland Habitat for Humanity and Karamu House, which is a theater and community arts center. We serve as general counsel for some clients and provide legal advice on an as needed basis for others. The Clinic provides legal advice on real estate matters, corporate governance, transactions, and tax issues. The complexity of matters that we handle ranges from drafting a code of regulations to representing clients in large development projects such as a $5.1 million community center for seniors

Physical Preparation in Female Rugby Codes: An Investigation of Current Practices

Female sports have recently seen a dramatic rise in participation and professionalism world-wide. Despite progress, the infrastructure and general sport science provisions in many female sports are behind their male counterparts. From a performance perspective, marked differences in physical and physiological characteristics can be seen between the sexes. Although physical preparation practices for male athletes are known, there are currently no published literature pertaining exclusively to female athletes. This information would provide invaluable data for both the researcher and practitioner alike. This survey therefore aimed to examine current practices utilized in female rugby codes (union, league, and sevens). A questionnaire assessing seasonal physical preparation practices, recovery, monitoring and sport science technology, and unique aspects in female rugby was developed. Thirty-seven physical preparation practitioners (32 males, 5 females) responded to the questionnaire. Most participants (78%) worked with national or regional/state level female athletes. Performance testing was more frequently assessed in the pre- (97%) and in-season (86%), than off-season (23%). Resistance, cardiovascular, sprint and plyometric training, and recovery sessions were all believed to be important to enhancing performance and implemented by most participants (≥ 89%). Sport science technologies were commonly (54%) utilized to inform current practice. Menstrual cycle phase was monitored by 22% of practitioners. The most frequently reported unique considerations in female rugby codes included psycho-social aspects (41%), the menstrual cycle (22%), and physical differences (22%). Practitioners working with female rugby can use the presented data to inform and develop current practices

Prognostic potential of body composition indices in detecting risk of musculoskeletal injury in army officer cadet profiles.

OBJECTIVES: High values in most of the body composition indices have been related to musculoskeletal injuries, but limited data exists on the accuracy of these diagnoses when detecting musculoskeletal injuries in military populations. METHODS: The suitability of body fat percentage, body mass index, fat mass index and fat free mass index to identify injury risk was examined in a group of army officer recruits. All body composition diagnoses were measured in 268 male army officer recruits prior to the commencement of basic combat training. Musculoskeletal injury was identified using codes from the International Classification of Diseases. The area under the curve, in the receiver operating characteristic curve, was used to quantify the overall ability to discriminate between those who were injured and those who were not. RESULTS: The statistics indicated that all indices, apart from body mass index, had a significant possibility to detect musculoskeletal injury potential (p 22, for fat mass index >6.5 and for fat free mass index <16.5. CONCLUSION: Body mass index values can not similarly detect the possibility of occurrence of musculoskeletal injuries in army officer recruits, just as other body composition diagnoses related to fat mass or/and free fat mass. However, the cut off-points related to the overall diagnostic performance of each body composition index should be used with caution and in accordance with the aims of each experimental setting

Applied sport science and medicine of women’s rugby codes: a systematic-scoping review and consensus on future research priorities protocol

Women’s rugby (rugby league, rugby union and rugby sevens) has recently grown in participation and professionalisation. There is under-representation of women-only cohorts within applied sport science and medicine research and within the women’s rugby evidence base. The aims of this article are: Part 1: to undertake a systematic-scoping review of the applied sport science and medicine of women’s rugby, and Part 2: to develop a consensus statement on future research priorities. This article will be designed in two parts: Part 1: a systematic-scoping review, and Part 2: a three-round Delphi consensus method. For Part 1, systematic searches of three electronic databases (PubMed (MEDLINE), Scopus, SPORTDiscus (EBSCOhost)) will be performed from the earliest record. These databases will be searched to identify any sport science and medicine themed studies within women’s rugby. The Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews will be adhered to. Part 2 involves a three-round Delphi consensus method to identify future research priorities. Identified experts in women’s rugby will be provided with overall findings from Part 1 to inform decision-making. Participants will then be asked to provide a list of research priority areas. Over the three rounds, priority areas achieving consensus (≥70% agreement) will be identified. This study has received institutional ethical approval. When complete, the manuscript will be submitted for publication in a peer-reviewed journal. The findings of this article will have relevance for a wide range of stakeholders in women’s rugby, including policymakers and governing bodies

Developing a framework for the analysis of power through depotentia

Stakeholder participation in tourism policy-making is usually perceived as providing a means of empowerment. However participatory processes drawing upon stakeholders from traditionally empowered backgrounds may provide the means of removing empowerment from stakeholders. Such an outcome would be in contradiction to the claims that participatory processes improve both inclusivity and sustainability. In order to form an understanding of the sources through which empowerment may be removed, an analytical perspective has been developed deriving from Lukes�s views of power dating from 1974. This perspective considers the concept of depotentia as the removal of �power to� without speculating upon the underlying intent and also provides for the multidimensionality of power to be examined within a single study. The application of this analytical perspective has been tested upon findings of the government-commissioned report of the Countryside and Community Research Unit in 2005. The survey and report investigated the progress of Local Access Forums in England created in response to the Countryside and Rights of Way Act 2000. Consideration of the data from this perspective permits the classification of individual sources of depotentia which can each be addressed and potentially enable stakeholder groups to reverse loss of empowerment where it has occurred