B(Ds^+ -> l^+ nu) and the Decay Constant f_(D_s^+)

I report final CLEO-c results on the purely leptonic decays of the D_s^+ -> l^+ nu, for the cases when l^+ is a mu^+ or tau^+, when it decays into pi^+ anti-nu, using 314/pb of data at 4.170 GeV. I also include preliminary results from the tau^+ -> e^+ nu anti-nu channel using 195/pb. Combining both we measure f_{D_s}= 275 +/- 10 +/- 5 MeV, and f_{D_s^+}/{f_{D^+}=1.24 +/- 0.10 =/- 0.03 .Comment: Presented at "The 2007 Europhysics Conference on High Energy Physics," Manchester, England, 19-25 July 2007, to appear in the proceedings. Three pages, 1 figur

Celecoxib decreases prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer

Background Celecoxib inhibits PGE2 production in cancerous tissue. We previously reported that PGE2 levels in nipple aspirate fluid (NAF) and plasma were not decreased in women at increased breast cancer risk who received celecoxib 200 mg twice daily (bid). The endpoints of the current study were to determine if a short course of celecoxib 400 mg bid would decrease PGE2 levels in women 1) at increased breast cancer risk, and 2) with established breast cancer. Methods NAF and plasma samples were collected before, 2 weeks after taking celecoxib 400 mg bid, and two weeks after washout from 26 women who were at increased breast cancer risk. From 13 women with newly diagnosed breast cancer, NAF from the incident breast and plasma were collected before and on average 2 weeks after taking celecoxib. Additionally, in nine of the 13 women with breast cancer, NAF was collected from the contralateral breast. Results No consistent change in NAF or plasma PGE2 levels was noted in high risk premenopausal women. NAF PGE2 levels decreased after celecoxib administration in postmenopausal high risk women (p = 0.02), and in both the NAF (p = 0.02) and plasma (p = 0.03) of women with breast cancer. Conclusion Celecoxib 400 mg bid taken on average for 2 weeks significantly decreased NAF, but not plasma, PGE2 levels in postmenopausal high risk women, and decreased both NAF and plasma PGE2 levels in women with newly diagnosed breast cancer. PGE2 levels may predict celecoxib breast cancer prevention and treatment efficacy. Our observations are preliminary, and larger studies to confirm and extend these findings are warranted

Celecoxib concentration predicts decrease in prostaglandin E\u3csub\u3e2\u3c/sub\u3e concentrations in nipple aspirate fluid from high risk women

BACKGROUND: Epidemiologic studies suggest that long term low dose celecoxib use significantly lowers breast cancer risk. We previously demonstrated that 400 mg celecoxib taken twice daily for 2 weeks lowered circulating plasma and breast nipple aspirate fluid (NAF) prostaglandin (PG)E2 concentrations in post- but not premenopausal high risk women. We hypothesized that circulating concentrations of celecoxib influenced PGE2 response, and that plasma levels of the drug are influenced by menopausal status. To address these hypotheses, the aims of the study were to determine: 1) if circulating plasma concentrations of celecoxib correlated with the change in plasma or NAF PGE2 concentrations from baseline to end of treatment, and 2) whether menopausal status influenced circulating levels of celecoxib. METHODS: Matched NAF and plasma were collected from 46 high risk women who were administered celecoxib twice daily for two weeks, 20 subjects receiving 200 mg and 26 subjects 400 mg of the agent. NAF and plasma samples were collected before and 2 weeks after taking celecoxib. RESULTS: In women taking 400 mg bid celecoxib, plasma concentrations of the agent correlated inversely with the change in NAF PGE2 levels from pre- to posttreatment. Nonsignificant trends toward higher celecoxib levels were observed in post- compared to premenopausal women. There was a significant decrease in NAF but not plasma PGE2 concentrations in postmenopausal women who took 400 mg celecoxib (p = 0.03). CONCLUSION: In high risk women taking 400 mg celecoxib twice daily, plasma concentrations of celecoxib correlated with downregulation of PGE2 production by breast tissue. Strategies synergistic with celecoxib to downregulate PGE2 are of interest, in order to minimize the celecoxib dose required to have an effect

t-channel production of heavy charged leptons

We study the pair production of heavy charged exotic leptons at e+ e- colliders in the SU(2)_L x SU(2)_I x U(1)_Y model. This gauge group is a subgroup of the grand unification group E6; SU(2)_I commutes with the electric charge operator, and the three corresponding gauge bosons are electrically neutral. In addition to the standard photon and Z boson contributions, we also include the contributions from extra neutral gauge bosons. A t-channel contribution due to W_I-boson exchange, which is unsuppressed by mixing angles, is quite important. We calculate the left-right and forward-backward asymmetries, and discuss how to differentiate different models.Comment: Increased discussion of experimental signatures. Version accepted by PR

Warped Phenomenology

We explore the phenomenology associated with the recently proposed localized gravity model of Randall and Sundrum where gravity propagates in a 5-dimensional non-factorizable geometry and generates the 4-dimensional weak-Planck scale hierarchy by an exponential function of the compactification radius, called a warp factor. The Kaluza-Klein tower of gravitons which emerge in this scenario have strikingly different properties than in the factorizable case with large extra dimensions. We derive the form of the graviton tower interactions with the Standard Model fields and examine their direct production in Drell-Yan and dijet events at the Tevatron and LHC as well as the KK spectrum line-shape at high-energy linear \epem colliders. In the case where the first KK excitation is observed, we outline the procedure to uniquely determine the parameters of this scenario. We also investigate the effect of KK tower exchanges in contact interaction searches. We find that present experiments can place meaningful constraints on the parameters of this model.Comment: 14 pages, LaTex, 3 fig

Panel: Individual and/versus social creativity

The creative act is often thought of as an individual, even lonely, one: the inspiration in the bath, the artist isolated in the garret. The research student has to demonstrate that they found new knowledge and that it was “all their own work”. But how often are these individual acts a realistic model of the creative process? Even if inspiration does come in the bath, how many conversations had taken place before that moment? How much time has the “lonely” artist spent in cafes arguing with other artists about their work? If individual research is so important why do we advise a good student to join a successful research department

Vacuum Stability in Split Susy and Little Higgs Models

We study the stability of the effective higgs potential in the split supersymmetry and Little Higgs models. In particular, we study the effects of higher dimensional operators in the effective potential on the higgs mass predictions. We find that the size and sign of the higher dimensional operators can significantly change the higgs mass required to maintain vacuum stability in Split Susy models. In the Little Higgs models the effects of higher dimensional operators can be large because of a relatively lower cut-off scale. Working with a specific model we find that a contribution from the higher dimensional operator with coefficient of O(1) can destabilize the vacuum.Comment: Latex 22 pages, 3 figures. Added discussion, published versio

Graviton-induced Bremsstrahlung at e^+e^- colliders

We consider graviton-induced Bremsstrahlung at future e^+e^- colliders in both the ADD and RS models, with emphasis on the photon perpendicular momentum and angular distribution. The photon spectrum is shown to be harder than in the Standard Model, and there is an enhancement for photons making large angles with respect to the beam. In the ADD scenario, the excess at large photon perpendicular momenta should be measurable for values of the cut-off up to about twice times the c.m. energy. In the RS scenario, radiative return to graviton resonances below the c.m. energy can lead to large enhancements of the cross section.Comment: 23 pages, including figure

Constraints on charged Higgs bosons from D(s)+- -> mu+- nu and D(s)+- -> tau+- nu

The decays D(s)+- -> mu+- nu and D(s)+- -> tau+- nu have traditionally been used to measure the D(s)+- meson decay constant f_D(s). Recent measurements at CLEO-c and the B factories suggest a branching ratio for both decays somewhat higher than the Standard Model prediction using f_D(s) from unquenched lattice calculations. The charged Higgs boson (H+-) in the Two Higgs Doublet Model (Type II) would also mediate these decays, but any sizeable contribution from H+- can only suppress the branching ratios and consequently is now slightly disfavoured. It is shown that constraints on the parameters tan(beta) and m_H+- from such decays can be competitive with and complementary to analogous constraints derived from the leptonic meson decays B+- -> tau+- nu_tau and K+- -> mu+- nu_mu, especially if lattice calculations eventually prefer f_D(s) < 250 MeV.Comment: 18 pages, 4 figure